SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '939'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhA-4a4lA:
24.5		 1uwhA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwhB-4a4lA:
24.3		 1uwhB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjA-4a4lA:
6.7		 1uwjA-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
None
None
None
 0.71A 1uwjB-4a4lA:
6.7		 1uwjB-4a4lA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 10 ARG A  57
LEU A  59
ALA A  80
LYS A  82
VAL A 114
LEU A 130
LEU A 132
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
 0.76A 3aoxA-4a4lA:
23.5		 3aoxA-4a4lA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 12 LEU A 745
GLY A 762
GLY A 765
GLY A 764
PRO A 742
 None
MG  A1939 (-3.9A)
MG  A1939 (-3.8A)
None
None
 1.06A 3axzA-2yhgA:
undetectable		 3axzA-2yhgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
GLY A  60
ALA A  80
LYS A  82
VAL A 114
CYH A 133
 939  A1331 (-3.7A)
939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
 0.53A 3c7qA-4a4lA:
21.8		 3c7qA-4a4lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1939 (-3.0A)
None
 0.87A 3elzA-2yhaA:
undetectable		 3elzA-2yhaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		3 / 3 VAL A 635
LYS A 638
HIS A 580
 None
SO4  A1939 (-3.4A)
None
 0.74A 3elzA-2yhbA:
undetectable		 3elzA-2yhbA:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 ALA A  80
LYS A  82
GLU A 101
LEU A 132
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
 0.43A 3lfaA-4a4lA:
19.1		 3lfaA-4a4lA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
 0.72A 3og7A-4a4lA:
18.3		 3og7A-4a4lA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
 None
None
None
SO4  A1939 (-3.9A)
 1.36A 3rv5C-2yhaA:
undetectable
3rv5D-2yhaA:
undetectable		 3rv5C-2yhaA:
14.92
3rv5D-2yhaA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2
(Neurospora
crassa) 		4 / 4 VAL A 532
PHE A 554
PHE A 582
VAL A 611
 None
None
None
SO4  A1939 ( 4.2A)
 1.40A 3rv5C-2yhbA:
undetectable
3rv5D-2yhbA:
undetectable		 3rv5C-2yhbA:
13.63
3rv5D-2yhbA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		4 / 5 SER A 799
ILE A 807
GLY A 764
PRO A 742
 MG  A1939 (-4.4A)
None
None
None
 1.04A 3uboB-2yhgA:
undetectable		 3uboB-2yhgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 VAL A 113
VAL A 114
CYH A 133
ILE A 192
 None
None
939  A1331 (-4.0A)
None
 0.48A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 VAL A 113
VAL A 114
ILE A 192
ASP A 194
 None
None
None
939  A1331 (-3.1A)
 0.55A 3wzeA-4a4lA:
16.6		 3wzeA-4a4lA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
LEU A 130
LEU A 132
GLY A 193
ASP A 194
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.45A 3zbfA-4a4lA:
20.8		 3zbfA-4a4lA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 9 GLY A 765
GLY A 764
ASN A 753
GLU A 798
ILE A 807
 MG  A1939 (-3.8A)
None
None
None
None
 1.34A 4fgjA-2yhgA:
2.3
4fgjB-2yhgA:
3.9		 4fgjA-2yhgA:
19.85
4fgjB-2yhgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 11 ILE A 807
GLY A 765
GLY A 764
ASN A 753
GLU A 798
 None
MG  A1939 (-3.8A)
None
None
None
 1.41A 4fglA-2yhgA:
3.9
4fglB-2yhgA:
3.8		 4fglA-2yhgA:
19.85
4fglB-2yhgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 LEU A  59
GLY A  62
ALA A  80
LYS A  82
LEU A 130
LEU A 132
ASP A 194
 939  A1331 (-3.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 ( 4.7A)
939  A1331 (-4.4A)
939  A1331 (-3.1A)
 0.61A 4mkcA-4a4lA:
24.8		 4mkcA-4a4lA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 5 LEU A  59
VAL A 114
VAL A 128
ARG A 175
 939  A1331 (-3.7A)
None
None
None
 0.59A 4r7iA-4a4lA:
22.5		 4r7iA-4a4lA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 1.35A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 0.92A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 1.36A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.90A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
SER A 137
PHE A 183
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
 0.72A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 10 LEU A  59
LEU A 108
VAL A 114
VAL A 128
ARG A 175
ILE A 192
 939  A1331 (-3.7A)
None
None
None
None
None
 0.82A 4u0iA-4a4lA:
22.8		 4u0iA-4a4lA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.68A 4xv2A-4a4lA:
18.4		 4xv2A-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
ASP A 194
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
None
 0.65A 4xv2B-4a4lA:
24.7		 4xv2B-4a4lA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 12 LEU A 745
GLY A 762
GLY A 765
GLY A 764
PRO A 742
 None
MG  A1939 (-3.9A)
MG  A1939 (-3.8A)
None
None
 1.02A 4yvgA-2yhgA:
undetectable		 4yvgA-2yhgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.68A 5cswA-4a4lA:
24.3		 5cswA-4a4lA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.71A 5cswB-4a4lA:
18.2		 5cswB-4a4lA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ALA A  80
LYS A  82
GLU A 101
CYH A 133
LEU A 167
HIS A 174
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.0A)
None
None
None
 0.78A 5hi2A-4a4lA:
15.2		 5hi2A-4a4lA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.75A 5hieA-4a4lA:
23.5		 5hieA-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.77A 5hieB-4a4lA:
23.4		 5hieB-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 GLY A  60
ALA A  80
LYS A  82
PHE A 183
GLY A 193
ASP A 194
 939  A1331 ( 4.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
939  A1331 (-3.1A)
 0.82A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 GLY A  60
GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 4.7A)
939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.83A 5hieC-4a4lA:
20.4		 5hieC-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		5 / 12 GLY A  62
ALA A  80
LYS A  82
PHE A 183
GLY A 193
 939  A1331 ( 3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
None
 0.76A 5hieD-4a4lA:
23.7		 5hieD-4a4lA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 8 ALA A  80
GLU A 101
CYH A 133
ASP A 194
 939  A1331 (-3.5A)
None
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.44A 5owrA-4a4lA:
24.3		 5owrA-4a4lA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
GLU A 101
VAL A 114
PHE A 183
GLY A 193
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
None
None
939  A1331 (-4.0A)
None
 0.45A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  80
LYS A  82
GLU A 101
VAL A 114
PHE A 183
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
None
939  A1331 (-4.0A)
 0.60A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 5 HIS A 105
LEU A 132
CYH A 133
ASP A 194
 None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.72A 5vcvA-4a4lA:
26.1		 5vcvA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		4 / 4 VAL A 114
LEU A 132
ASN A 181
ASP A 194
 None
939  A1331 (-4.4A)
None
939  A1331 (-3.1A)
 0.80A 5vcyA-4a4lA:
26.0		 5vcyA-4a4lA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yhg CELLULOSE-BINDING
PROTEIN
(Saccharophagus
degradans) 		5 / 12 LEU A 745
GLY A 762
GLY A 765
GLY A 764
PRO A 742
 None
MG  A1939 (-3.9A)
MG  A1939 (-3.8A)
None
None
 1.00A 5wyqB-2yhgA:
undetectable		 5wyqB-2yhgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens) 		7 / 12 LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
ASP A 194
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.62A 5y80A-4a4lA:
27.9		 5y80A-4a4lA:
12.54