SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '92N'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3A_A_TEPA1434_1 (CHITINASE)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	3 / 3	TRP A 249 THR A 258 TYR A 129	None 92N A 602 (-3.8A) 92N A 602 (-4.0A)	1.25A	2a3aA-5nnoA: undetectable	2a3aA-5nnoA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3B_A_CFFA1434_1 (CHITINASE)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	3 / 3	TRP A 249 THR A 258 TYR A 129	None 92N A 602 (-3.8A) 92N A 602 (-4.0A)	1.29A	2a3bA-5nnoA: undetectable	2a3bA-5nnoA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NRR_A_D16A530_1 (DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	5 / 12	ALA A 416 ILE A 260 ASN A 128 GLY A 225 TYR A 199	None 92N A 602 ( 4.7A) NAD A 601 ( 3.3A) NAD A 601 (-3.3A) NAD A 601 (-4.9A)	1.16A	3nrrA-5nnoA: undetectable	3nrrA-5nnoA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP4_A_COCA706_1 (DOPAMINE TRANSPORTER)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	5 / 11	ALA A 426 ASP A 263 GLY A 415 SER A 259 GLY A 226	92N A 602 (-3.6A) None None NAD A 601 ( 3.1A) None	1.29A	4xp4A-5nnoA: undetectable	4xp4A-5nnoA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP4_A_COCA706_1 (DOPAMINE TRANSPORTER)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	5 / 11	ALA A 426 ASP A 263 GLY A 435 SER A 259 GLY A 226	92N A 602 (-3.6A) None None NAD A 601 ( 3.1A) None	1.04A	4xp4A-5nnoA: undetectable	4xp4A-5nnoA: 23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQX_A_ROCA101_2 (PROTEASE E35D-SQV)	5nno	ALDEHYDE DEHYDROGENASE (Trypanosoma brucei)	5 / 9	LEU A 393 VAL A 423 ILE A 253 GLY A 256 ILE A 260	NAD A 601 (-4.3A) None None None 92N A 602 ( 4.7A)	1.09A	5kqxB-5nnoA: undetectable	5kqxB-5nnoA: 11.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2A3A_A_TEPA1434_1","CHITINASE","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",3,"TRP A 249;THR A 258;TYR A 129","None;92N A 602 (-3.8A);92N A 602 (-4.0A)","1.25A","2a3aA-5nnoA:undetectable",null],["2A3B_A_CFFA1434_1","CHITINASE","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",3,"TRP A 249;THR A 258;TYR A 129","None;92N A 602 (-3.8A);92N A 602 (-4.0A)","1.29A","2a3bA-5nnoA:undetectable","2a3aA-5nnoA:21.82"],["3NRR_A_D16A530_1","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",5,"ALA A 416;ILE A 260;ASN A 128;GLY A 225;TYR A 199","None;92N A 602 ( 4.7A);NAD A 601 ( 3.3A);NAD A 601 (-3.3A);NAD A 601 (-4.9A)","1.16A","3nrrA-5nnoA:undetectable","2a3bA-5nnoA:21.82"],["4XP4_A_COCA706_1","DOPAMINE TRANSPORTER","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",5,"ALA A 426;ASP A 263;GLY A 415;SER A 259;GLY A 226","92N A 602 (-3.6A);None;None;NAD A 601 ( 3.1A);None","1.29A","4xp4A-5nnoA:undetectable","3nrrA-5nnoA:21.01"],["4XP4_A_COCA706_1","DOPAMINE TRANSPORTER","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",5,"ALA A 426;ASP A 263;GLY A 435;SER A 259;GLY A 226","92N A 602 (-3.6A);None;None;NAD A 601 ( 3.1A);None","1.04A","4xp4A-5nnoA:undetectable","4xp4A-5nnoA:23.49"],["5KQX_A_ROCA101_2","PROTEASE E35D-SQV;PROTEASE E35D-SQV","5nno","ALDEHYDE DEHYDROGENASE","Trypanosoma brucei",5,"LEU A 393;VAL A 423;ILE A 253;GLY A 256;ILE A 260","NAD A 601 (-4.3A);None;None;None;92N A 602 ( 4.7A)","1.09A","5kqxB-5nnoA:undetectable","4xp4A-5nnoA:23.49"]]