SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '92K'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  79
ILE A  32
HIS A 207
ASP A  75
 92K  A 302 (-3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-4.0A)
MN  A 301 ( 1.8A)
 1.11A 2xadA-5nnbA:
undetectable		 2xadA-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  69
ILE A  32
HIS A  79
ASP A  75
 MN  A 301 ( 3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-3.2A)
MN  A 301 ( 1.8A)
 1.05A 2xadB-5nnbA:
undetectable		 2xadB-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 HIS A  79
ILE A  32
HIS A 207
ASP A  75
 92K  A 302 (-3.2A)
92K  A 302 (-4.1A)
92K  A 302 (-4.0A)
MN  A 301 ( 1.8A)
 1.11A 2xadC-5nnbA:
undetectable		 2xadC-5nnbA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 5 PRO A  35
THR A 189
VAL A 190
GLY A 191
 None
None
None
92K  A 302 ( 4.3A)
 1.08A 3elzA-5nnbA:
undetectable		 3elzA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.63A 5ncdA-5nnbA:
undetectable
5ncdD-5nnbA:
undetectable		 5ncdA-5nnbA:
undetectable
5ncdD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.61A 5ncdB-5nnbA:
undetectable
5ncdC-5nnbA:
undetectable		 5ncdB-5nnbA:
undetectable
5ncdC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.77A 5nekB-5nnbA:
undetectable		 5nekB-5nnbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 8 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.69A 5nekD-5nnbA:
undetectable		 5nekD-5nnbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		4 / 6 ASP A  75
HIS A  79
HIS A 207
HIS A  73
 MN  A 301 ( 1.8A)
92K  A 302 (-3.2A)
92K  A 302 (-4.0A)
MN  A 301 (-3.2A)
 0.70A 5nelA-5nnbA:
undetectable
5nelD-5nnbA:
undetectable		 5nelA-5nnbA:
undetectable
5nelD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.29A 5nnaA-5nnbA:
43.5		 5nnaA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.43A 5nnaA-5nnbA:
43.5		 5nnaA-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.32A 5nnaB-5nnbA:
43.8		 5nnaB-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.40A 5nnaB-5nnbA:
43.8		 5nnaB-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.33A 5nnaC-5nnbA:
43.4		 5nnaC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.42A 5nnaC-5nnbA:
43.4		 5nnaC-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		6 / 12 ILE A  32
LEU A  34
HIS A  79
ASP A 193
GLY A 197
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
92K  A 302 (-4.0A)
 1.28A 5nnaD-5nnbA:
42.9		 5nnaD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5nnb ISATIN HYDROLASE A
(Labrenzia
aggregata) 		12 / 12 ILE A  32
LEU A  34
HIS A  79
TRP A  80
PRO A 163
SER A 165
VAL A 190
GLY A 191
ASP A 193
GLY A 195
TYR A 204
HIS A 207
 92K  A 302 (-4.1A)
92K  A 302 (-4.4A)
92K  A 302 (-3.2A)
None
None
None
None
92K  A 302 ( 4.3A)
None
None
92K  A 302 (-3.6A)
92K  A 302 (-4.0A)
 0.46A 5nnaD-5nnbA:
42.9		 5nnaD-5nnbA:
undetectable