SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '924'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
7 / 12 LEU A 598
GLY A 599
GLY A 601
VAL A 606
LYS A 938
ASN A 941
ASP A 954
924  A1101 ( 4.1A)
None
None
924  A1101 ( 4.8A)
None
None
924  A1101 (-3.7A)
1.06A 2fumD-4g34A:
23.4
2fumD-4g34A:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.42A 2hyyA-4g34A:
20.6
2hyyA-4g34A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.54A 2hyyB-4g34A:
20.6
2hyyB-4g34A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana)
3 / 3 LEU A 289
LEU A 148
PHE A 291
None
None
DHK  A9241 (-3.4A)
0.61A 2pgrA-2o7qA:
3.7
2pgrA-2o7qA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 10 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.76A 3cs9A-4g34A:
21.0
3cs9A-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 9 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.77A 3cs9B-4g34A:
21.4
3cs9B-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 9 LEU A 598
VAL A 606
LYS A 621
VAL A 651
ILE A 885
VAL A 952
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
None
0.75A 3cs9C-4g34A:
20.9
3cs9C-4g34A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)
2wan PULLULANASE
(Bacillus
acidopullulyticu
s)
3 / 3 ARG A 756
GLU A 761
ASP A 815
None
GOL  A1924 (-3.8A)
None
0.93A 3g2oA-2wanA:
undetectable
3g2oA-2wanA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.50A 3k5vA-4g34A:
16.5
3k5vA-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.1A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.48A 3k5vB-4g34A:
18.8
3k5vB-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
7 / 12 LEU A 598
GLY A 599
VAL A 606
ALA A 619
LYS A 621
VAL A 651
ASP A 954
924  A1101 ( 4.1A)
None
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-4.6A)
924  A1101 (-3.7A)
0.67A 3lxkA-4g34A:
22.3
3lxkA-4g34A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 VAL A 606
LYS A 621
VAL A 651
ILE A 885
924  A1101 ( 4.8A)
None
924  A1101 (-4.6A)
924  A1101 ( 4.6A)
0.39A 3mssD-4g34A:
20.3
3mssD-4g34A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
0.84A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.79A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
LYS A 621
LEU A 642
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
None
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.75A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
2wan PULLULANASE
(Bacillus
acidopullulyticu
s)
5 / 12 LEU A 762
ALA A 763
LEU A 740
PHE A 817
GLY A 778
GOL  A1924 (-4.3A)
None
None
None
None
1.04A 4dm8B-2wanA:
undetectable
4dm8B-2wanA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 8 MET A 887
LEU A 883
ALA A 656
LEU A 658
924  A1101 (-3.7A)
None
None
None
0.82A 4ik6B-4g34A:
undetectable
4ik6B-4g34A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
GLY A 599
VAL A 606
ALA A 619
924  A1101 ( 4.1A)
None
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
0.26A 4o0wA-4g34A:
24.3
4o0wA-4g34A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana)
4 / 8 PHE A 291
SER A 300
ALA A 243
LEU A 269
DHK  A9241 (-3.4A)
DHK  A9241 (-2.8A)
DHK  A9241 ( 4.6A)
DHK  A9241 (-3.7A)
0.96A 4rkuA-2o7qA:
undetectable
4rkuJ-2o7qA:
undetectable
4rkuA-2o7qA:
20.52
4rkuJ-2o7qA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.99A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
0.80A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.73A 4rzvB-4g34A:
23.3
4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 6 LEU A 598
VAL A 606
LYS A 621
ILE A 650
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
None
0.49A 4tyjA-4g34A:
21.6
4tyjA-4g34A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana)
4 / 7 PHE A 291
SER A 300
ALA A 243
LEU A 269
DHK  A9241 (-3.4A)
DHK  A9241 (-2.8A)
DHK  A9241 ( 4.6A)
DHK  A9241 (-3.7A)
1.02A 4xk8A-2o7qA:
undetectable
4xk8A-2o7qA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.78A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.92A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
CYH A 890
PHE A 943
GLY A 953
ASP A 954
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 (-3.7A)
924  A1101 ( 4.4A)
1.43A 4xv2A-4g34A:
23.6
4xv2A-4g34A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.77A 5cswA-4g34A:
23.3
5cswA-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
0.73A 5cswA-4g34A:
23.3
5cswA-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.74A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
CYH A 890
GLY A 953
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
0.92A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
LEU A 642
CYH A 890
PHE A 943
PHE A 955
924  A1101 ( 4.8A)
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
0.88A 5cswB-4g34A:
23.3
5cswB-4g34A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 ( 4.4A)
None
0.81A 5hesB-4g34A:
22.6
5hesB-4g34A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieA-4g34A:
3.8
5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.75A 5hieA-4g34A:
3.8
5hieA-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieB-4g34A:
22.1
5hieB-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.74A 5hieB-4g34A:
22.1
5hieB-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
ILE A 885
PHE A 943
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 ( 4.6A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
0.49A 5hieD-4g34A:
22.4
5hieD-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 12 VAL A 606
ALA A 619
LYS A 621
ILE A 885
GLY A 953
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 ( 4.6A)
924  A1101 (-4.6A)
0.75A 5hieD-4g34A:
22.4
5hieD-4g34A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
4 / 7 GLY A 599
GLY A 601
GLY A 604
VAL A 606
None
None
None
924  A1101 ( 4.8A)
0.34A 5izjB-4g34A:
21.7
5izjB-4g34A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana)
4 / 4 GLY A 303
PRO A 302
VAL A 299
ARG A 279
None
None
None
DHK  A9241 (-2.7A)
1.25A 5uunA-2o7qA:
0.0
5uunB-2o7qA:
0.0
5uunA-2o7qA:
20.88
5uunB-2o7qA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
6 / 12 LEU A 598
VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 943
924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
0.36A 5vcyA-4g34A:
23.4
5vcyA-4g34A:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5ju6 BETA-GLUCOSIDASE
(Rasamsonia
emersonii)
5 / 9 GLY A 286
LEU A 289
ILE A 322
LEU A 313
ILE A 334
MAN  A 924 ( 3.7A)
None
None
None
None
0.93A 5vkqC-5ju6A:
undetectable
5vkqD-5ju6A:
undetectable
5vkqC-5ju6A:
19.49
5vkqD-5ju6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo
sapiens)
5 / 9 LEU A 598
ALA A 619
VAL A 651
MET A 887
CYH A 890
924  A1101 ( 4.1A)
924  A1101 (-3.5A)
924  A1101 (-4.6A)
924  A1101 (-3.7A)
924  A1101 (-3.9A)
0.61A 5w5vA-4g34A:
15.1
5w5vA-4g34A:
21.25