SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '924'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FUM_D_MIXD3539_1 (PROBABLESERINE/THREONINE-PROTEIN KINASE PKNB) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 7 / 12 | LEU A 598GLY A 599GLY A 601VAL A 606LYS A 938ASN A 941ASP A 954 | 924 A1101 ( 4.1A)NoneNone924 A1101 ( 4.8A)NoneNone924 A1101 (-3.7A) | 1.06A | 2fumD-4g34A:23.4 | 2fumD-4g34A:27.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HYY_A_STIA600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598LYS A 621VAL A 651ILE A 885 | 924 A1101 ( 4.1A)None924 A1101 (-4.6A)924 A1101 ( 4.6A) | 0.42A | 2hyyA-4g34A:20.6 | 2hyyA-4g34A:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2HYY_B_STIB600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598LYS A 621VAL A 651ILE A 885 | 924 A1101 ( 4.1A)None924 A1101 (-4.6A)924 A1101 ( 4.6A) | 0.54A | 2hyyB-4g34A:20.6 | 2hyyB-4g34A:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PGR_A_DCFA501_2 (ADENOSINE DEAMINASE) |
2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) | 3 / 3 | LEU A 289LEU A 148PHE A 291 | NoneNoneDHK A9241 (-3.4A) | 0.61A | 2pgrA-2o7qA:3.7 | 2pgrA-2o7qA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CS9_A_NILA600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 10 | LEU A 598VAL A 606LYS A 621VAL A 651ILE A 885VAL A 952 | 924 A1101 ( 4.1A)924 A1101 ( 4.8A)None924 A1101 (-4.6A)924 A1101 ( 4.6A)None | 0.76A | 3cs9A-4g34A:21.0 | 3cs9A-4g34A:27.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CS9_B_NILB600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 9 | LEU A 598VAL A 606LYS A 621VAL A 651ILE A 885VAL A 952 | 924 A1101 ( 4.1A)924 A1101 ( 4.8A)None924 A1101 (-4.6A)924 A1101 ( 4.6A)None | 0.77A | 3cs9B-4g34A:21.4 | 3cs9B-4g34A:27.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CS9_C_NILC600_2 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 9 | LEU A 598VAL A 606LYS A 621VAL A 651ILE A 885VAL A 952 | 924 A1101 ( 4.1A)924 A1101 ( 4.8A)None924 A1101 (-4.6A)924 A1101 ( 4.6A)None | 0.75A | 3cs9C-4g34A:20.9 | 3cs9C-4g34A:27.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G2O_A_SAMA500_1 (PCZA361.24) |
2wan | PULLULANASE (Bacillusacidopullulyticus) | 3 / 3 | ARG A 756GLU A 761ASP A 815 | NoneGOL A1924 (-3.8A)None | 0.93A | 3g2oA-2wanA:undetectable | 3g2oA-2wanA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K5V_A_STIA2_2 (TYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598LYS A 621VAL A 651ILE A 885 | 924 A1101 ( 4.1A)None924 A1101 (-4.6A)924 A1101 ( 4.6A) | 0.50A | 3k5vA-4g34A:16.5 | 3k5vA-4g34A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3K5V_B_STIB2_2 (TYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598LYS A 621VAL A 651ILE A 885 | 924 A1101 ( 4.1A)None924 A1101 (-4.6A)924 A1101 ( 4.6A) | 0.48A | 3k5vB-4g34A:18.8 | 3k5vB-4g34A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3LXK_A_MI1A1125_1 (TYROSINE-PROTEINKINASE JAK3) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 7 / 12 | LEU A 598GLY A 599VAL A 606ALA A 619LYS A 621VAL A 651ASP A 954 | 924 A1101 ( 4.1A)None924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-4.6A)924 A1101 (-3.7A) | 0.67A | 3lxkA-4g34A:22.3 | 3lxkA-4g34A:25.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MSS_D_STID1_2 (TYROSINE-PROTEINKINASE ABL1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | VAL A 606LYS A 621VAL A 651ILE A 885 | 924 A1101 ( 4.8A)None924 A1101 (-4.6A)924 A1101 ( 4.6A) | 0.39A | 3mssD-4g34A:20.3 | 3mssD-4g34A:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 ( 4.4A)None | 0.84A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619LYS A 621CYH A 890PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 ( 4.4A)None | 0.79A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606LYS A 621LEU A 642CYH A 890PHE A 955GLY A 956 | 924 A1101 ( 4.8A)None924 A1101 (-3.9A)924 A1101 (-3.9A)924 A1101 ( 4.4A)None | 0.75A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4DM8_B_REAB1501_1 (RETINOIC ACIDRECEPTOR BETA) |
2wan | PULLULANASE (Bacillusacidopullulyticus) | 5 / 12 | LEU A 762ALA A 763LEU A 740PHE A 817GLY A 778 | GOL A1924 (-4.3A)NoneNoneNoneNone | 1.04A | 4dm8B-2wanA:undetectable | 4dm8B-2wanA:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4IK6_B_LURB201_1 (TRANSTHYRETIN) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 8 | MET A 887LEU A 883ALA A 656LEU A 658 | 924 A1101 (-3.7A)NoneNoneNone | 0.82A | 4ik6B-4g34A:undetectable | 4ik6B-4g34A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4O0W_A_ADNA501_1 (AURORA KINASE A) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598GLY A 599VAL A 606ALA A 619 | 924 A1101 ( 4.1A)None924 A1101 ( 4.8A)924 A1101 (-3.5A) | 0.26A | 4o0wA-4g34A:24.3 | 4o0wA-4g34A:26.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RKU_A_PQNA5001_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1PHOTOSYSTEM IREACTION CENTERSUBUNIT IX) |
2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) | 4 / 8 | PHE A 291SER A 300ALA A 243LEU A 269 | DHK A9241 (-3.4A)DHK A9241 (-2.8A)DHK A9241 ( 4.6A)DHK A9241 (-3.7A) | 0.96A | 4rkuA-2o7qA:undetectable4rkuJ-2o7qA:undetectable | 4rkuA-2o7qA:20.524rkuJ-2o7qA:7.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.99A | 4rzvB-4g34A:23.3 | 4rzvB-4g34A:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 ( 4.4A)None | 0.80A | 4rzvB-4g34A:23.3 | 4rzvB-4g34A:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619LYS A 621CYH A 890PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 ( 4.4A)None | 0.73A | 4rzvB-4g34A:23.3 | 4rzvB-4g34A:28.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TYJ_A_0LIA801_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 6 | LEU A 598VAL A 606LYS A 621ILE A 650 | 924 A1101 ( 4.1A)924 A1101 ( 4.8A)NoneNone | 0.49A | 4tyjA-4g34A:21.6 | 4tyjA-4g34A:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XK8_A_PQNA844_1 (PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1) |
2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) | 4 / 7 | PHE A 291SER A 300ALA A 243LEU A 269 | DHK A9241 (-3.4A)DHK A9241 (-2.8A)DHK A9241 ( 4.6A)DHK A9241 (-3.7A) | 1.02A | 4xk8A-2o7qA:undetectable | 4xk8A-2o7qA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.78A | 4xv2A-4g34A:23.6 | 4xv2A-4g34A:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619LYS A 621CYH A 890GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.92A | 4xv2A-4g34A:23.6 | 4xv2A-4g34A:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606CYH A 890PHE A 943GLY A 953ASP A 954PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 (-4.6A)924 A1101 (-3.7A)924 A1101 ( 4.4A) | 1.43A | 4xv2A-4g34A:23.6 | 4xv2A-4g34A:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.77A | 5cswA-4g34A:23.3 | 5cswA-4g34A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619LYS A 621CYH A 890PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 ( 4.4A) | 0.73A | 5cswA-4g34A:23.3 | 5cswA-4g34A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619CYH A 890PHE A 943GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.74A | 5cswB-4g34A:23.3 | 5cswB-4g34A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619LYS A 621CYH A 890GLY A 953PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 (-4.6A)924 A1101 ( 4.4A) | 0.92A | 5cswB-4g34A:23.3 | 5cswB-4g34A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606LEU A 642CYH A 890PHE A 943PHE A 955 | 924 A1101 ( 4.8A)924 A1101 (-3.9A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 ( 4.4A) | 0.88A | 5cswB-4g34A:23.3 | 5cswB-4g34A:28.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HES_B_032B401_1 (MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | VAL A 606ALA A 619LYS A 621ILE A 885PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 ( 4.6A)924 A1101 ( 4.4A)None | 0.81A | 5hesB-4g34A:22.6 | 5hesB-4g34A:27.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619ILE A 885PHE A 943GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 ( 4.6A)924 A1101 ( 4.2A)924 A1101 (-4.6A) | 0.49A | 5hieA-4g34A:3.8 | 5hieA-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619LYS A 621ILE A 885GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 ( 4.6A)924 A1101 (-4.6A) | 0.75A | 5hieA-4g34A:3.8 | 5hieA-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619ILE A 885PHE A 943GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 ( 4.6A)924 A1101 ( 4.2A)924 A1101 (-4.6A) | 0.49A | 5hieB-4g34A:22.1 | 5hieB-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619LYS A 621ILE A 885GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 ( 4.6A)924 A1101 (-4.6A) | 0.74A | 5hieB-4g34A:22.1 | 5hieB-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619ILE A 885PHE A 943GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 ( 4.6A)924 A1101 ( 4.2A)924 A1101 (-4.6A) | 0.49A | 5hieD-4g34A:22.4 | 5hieD-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 12 | VAL A 606ALA A 619LYS A 621ILE A 885GLY A 953 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 ( 4.6A)924 A1101 (-4.6A) | 0.75A | 5hieD-4g34A:22.4 | 5hieD-4g34A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IZJ_F_AZ1F2_1 (CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA47P-AZ1-DAR-DAR-DAR) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 4 / 7 | GLY A 599GLY A 601GLY A 604VAL A 606 | NoneNoneNone924 A1101 ( 4.8A) | 0.34A | 5izjB-4g34A:21.7 | 5izjB-4g34A:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UUN_B_ACTB310_0 (GLUTATHIONES-TRANSFERASE-LIKEPROTEIN) |
2o7q | BIFUNCTIONAL3-DEHYDROQUINATEDEHYDRATASE/SHIKIMATE DEHYDROGENASE (Arabidopsisthaliana) | 4 / 4 | GLY A 303PRO A 302VAL A 299ARG A 279 | NoneNoneNoneDHK A9241 (-2.7A) | 1.25A | 5uunA-2o7qA:0.05uunB-2o7qA:0.0 | 5uunA-2o7qA:20.885uunB-2o7qA:20.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 6 / 12 | LEU A 598VAL A 606ALA A 619LYS A 621CYH A 890PHE A 943 | 924 A1101 ( 4.1A)924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 ( 4.2A) | 0.36A | 5vcyA-4g34A:23.4 | 5vcyA-4g34A:30.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VKQ_C_PCFC1805_0 (NO MECHANORECEPTORPOTENTIAL C ISOFORML) |
5ju6 | BETA-GLUCOSIDASE (Rasamsoniaemersonii) | 5 / 9 | GLY A 286LEU A 289ILE A 322LEU A 313ILE A 334 | MAN A 924 ( 3.7A)NoneNoneNoneNone | 0.93A | 5vkqC-5ju6A:undetectable5vkqD-5ju6A:undetectable | 5vkqC-5ju6A:19.495vkqD-5ju6A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5W5V_A_ANWA701_0 (SERINE/THREONINE-PROTEIN KINASE TBK1) |
4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homosapiens) | 5 / 9 | LEU A 598ALA A 619VAL A 651MET A 887CYH A 890 | 924 A1101 ( 4.1A)924 A1101 (-3.5A)924 A1101 (-4.6A)924 A1101 (-3.7A)924 A1101 (-3.9A) | 0.61A | 5w5vA-4g34A:15.1 | 5w5vA-4g34A:21.25 |