SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '919'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.93A 1hxwB-5ej1A:
undetectable		 1hxwB-5ej1A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		4 / 4 SER A 611
VAL A 607
PHE A 690
VAL A 158
 C2E  A 919 (-3.5A)
None
None
None
 1.21A 1o86A-5ej1A:
3.9		 1o86A-5ej1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 4 VAL A 701
ALA A 715
LEU A 751
PHE A 767
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-4.5A)
919  A1101 (-3.8A)
 0.34A 1q97B-6cnhA:
31.4		 1q97B-6cnhA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.73A 1uwhA-6cnhA:
21.8		 1uwhA-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.75A 1uwhB-6cnhA:
21.7		 1uwhB-6cnhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 718
VAL A 677
VAL A 716
ALA A 715
LEU A 683
 None
None
None
919  A1101 (-3.5A)
None
 1.03A 1vptA-6cnhA:
undetectable		 1vptA-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 9 GLY A 614
SER A 619
LEU A 622
TYR A 692
LEU A 716
 None
EDO  A 919 (-4.0A)
None
None
None
 1.28A 1y7iA-3s1sA:
2.5		 1y7iA-3s1sA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1nr4 THYMUS AND
ACTIVATION-REGULATED
CHEMOKINE
(Homo
sapiens) 		4 / 7 SER A  35
ARG A  36
LEU A  12
GLU A  13
 SO4  A9199 (-4.6A)
None
SO4  A9199 (-4.1A)
None
 1.01A 2cdqB-1nr4A:
undetectable		 2cdqB-1nr4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.81A 2ieoA-5ej1A:
undetectable		 2ieoA-5ej1A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 676
GLY A 655
ILE A 672
VAL A 685
VAL A 681
 None
None
C2E  A 919 (-3.5A)
None
None
 0.89A 2nnkB-5ej1A:
undetectable		 2nnkB-5ej1A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 8 ASN A 700
SER A 699
VAL A 702
PHE A 767
 None
SO4  A1102 (-2.6A)
None
919  A1101 (-3.8A)
 1.14A 2wekA-6cnhA:
undetectable		 2wekA-6cnhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 8 ASN A 700
SER A 699
VAL A 702
PHE A 767
 None
SO4  A1102 (-2.6A)
None
919  A1101 (-3.8A)
 1.15A 2wekB-6cnhA:
undetectable		 2wekB-6cnhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4iig BETA-GLUCOSIDASE 1
(Aspergillus
aculeatus) 		5 / 10 SER A 260
ARG A 329
ALA A 291
LEU A 292
ALA A 737
 MAN  A 919 ( 4.8A)
None
None
None
None
 1.50A 2wseB-4iigA:
undetectable		 2wseB-4iigA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
(Arabidopsis
thaliana) 		5 / 12 ALA A 463
HIS A 417
SER A 512
TYR A 509
LEU A 484
 SO4  A 919 ( 4.7A)
None
SO4  A 916 (-2.3A)
None
None
 0.88A 3bxoA-4mn8A:
undetectable		 3bxoA-4mn8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		3 / 3 CYH A 750
HIS A 749
PHE A 748
 919  A1101 ( 4.4A)
None
None
 1.21A 3cr4X-6cnhA:
undetectable		 3cr4X-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.58A 3cs9B-6cnhA:
21.9		 3cs9B-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL A 701
LYS A 717
LEU A 822
ASP A 834
 919  A1101 (-4.7A)
SO4  A1102 ( 2.8A)
None
919  A1101 (-4.5A)
 0.59A 3cs9D-6cnhA:
20.5		 3cs9D-6cnhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.83A 3ekpD-5ej1A:
undetectable		 3ekpD-5ej1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.86A 3ektA-5ej1A:
undetectable		 3ektA-5ej1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.88A 3ektC-5ej1A:
undetectable		 3ektC-5ej1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.78A 3ekvA-5ej1A:
undetectable		 3ekvA-5ej1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.82A 3gcsA-6cnhA:
25.5		 3gcsA-6cnhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 VAL A 701
ALA A 715
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.72A 3gcsA-6cnhA:
25.5		 3gcsA-6cnhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 VAL A 701
ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.70A 3gp0A-6cnhA:
26.9		 3gp0A-6cnhA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 VAL A 701
ALA A 715
LYS A 717
GLU A 732
LEU A 736
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
 0.93A 3hegA-6cnhA:
26.2		 3hegA-6cnhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
 0.54A 3ik3A-6cnhA:
21.5		 3ik3A-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.46A 3ik3A-6cnhA:
21.5		 3ik3A-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
 0.49A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.42A 3ik3B-6cnhA:
21.2		 3ik3B-6cnhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.78A 3nu3B-5ej1A:
undetectable		 3nu3B-5ej1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.79A 3nujB-5ej1A:
undetectable		 3nujB-5ej1A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.75A 3nuoB-5ej1A:
undetectable		 3nuoB-5ej1A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.95A 3oy4B-5ej1A:
undetectable		 3oy4B-5ej1A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 VAL A 701
ALA A 715
GLU A 732
LEU A 736
PHE A 767
LEU A 806
HIS A 813
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-3.8A)
None
919  A1101 (-4.2A)
 0.57A 3rgfA-6cnhA:
11.7		 3rgfA-6cnhA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosA-6cnhA:
21.1		 3zosA-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.69A 3zosB-6cnhA:
2.3		 3zosB-6cnhA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		9 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.78A 4c8bA-6cnhA:
22.2		 4c8bA-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		9 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.71A 4c8bB-6cnhA:
22.0		 4c8bB-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.90A 4dqbB-5ej1A:
undetectable		 4dqbB-5ej1A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.87A 4dqcB-5ej1A:
undetectable		 4dqcB-5ej1A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.93A 4dqeB-5ej1A:
undetectable		 4dqeB-5ej1A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.94A 4dqhB-5ej1A:
undetectable		 4dqhB-5ej1A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.84A 4ll3B-5ej1A:
undetectable		 4ll3B-5ej1A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.85A 4ll3A-5ej1A:
undetectable		 4ll3A-5ej1A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 10 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.94A 4njtB-5ej1A:
undetectable		 4njtB-5ej1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		4 / 5 ILE A 672
ARG A 580
ASP A 609
VAL A 653
 C2E  A 919 (-3.5A)
C2E  A 920 ( 3.7A)
C2E  A 919 (-3.2A)
None
 0.91A 4nkxC-5ej1A:
undetectable		 4nkxC-5ej1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		4 / 5 ILE A 672
ARG A 580
ASP A 609
VAL A 653
 C2E  A 919 (-3.5A)
C2E  A 920 ( 3.7A)
C2E  A 919 (-3.2A)
None
 0.88A 4nkxD-5ej1A:
undetectable		 4nkxD-5ej1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 733
LEU A 730
GLY A 729
GLN A 726
VAL A 701
 None
None
None
None
919  A1101 (-4.7A)
 0.81A 4ok1A-6cnhA:
undetectable		 4ok1A-6cnhA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 186
TYR A 140
TRP A 226
 None
None
GOL  A 919 (-3.3A)
 1.02A 4p7nA-3a21A:
12.1		 4p7nA-3a21A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.75A 4rvjB-5ej1A:
undetectable		 4rvjB-5ej1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.76A 4rvjD-5ej1A:
undetectable		 4rvjD-5ej1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.55A 4tyjA-6cnhA:
22.0		 4tyjA-6cnhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		7 / 12 ALA A 715
LEU A 736
HIS A 813
LEU A 822
CYH A 833
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.1A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.83A 4u0iA-6cnhA:
21.4		 4u0iA-6cnhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.72A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.50A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.58A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.59A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.61A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.73A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG
(Homo
sapiens) 		6 / 12 LYS A 717
GLU A 732
LEU A 736
LEU A 751
LEU A 806
HIS A 813
 SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
None
919  A1101 (-4.2A)
 0.61A 5hi2A-6cnhA:
21.4		 5hi2A-6cnhA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 9 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.83A 5kr0B-5ej1A:
undetectable		 5kr0B-5ej1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 579
ARG A 584
ARG A 658
 C2E  A 919 ( 3.1A)
C2E  A 920 ( 3.3A)
C2E  A 919 ( 4.5A)
 0.95A 5vcgA-5ej1A:
undetectable		 5vcgA-5ej1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5zln TOLL-LIKE RECEPTOR 9
(Mus
musculus) 		4 / 6 SER A 342
GLU A 368
ARG A 337
ASP A 314
 None
None
SO4  A 919 (-3.7A)
None
 1.26A 5zw4A-5zlnA:
undetectable		 5zw4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 676
GLY A 655
ILE A 672
VAL A 685
VAL A 681
 None
None
C2E  A 919 (-3.5A)
None
None
 0.86A 6dh0B-5ej1A:
undetectable		 6dh0B-5ej1A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 5ej1 PUTATIVE CELLULOSE
SYNTHASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 688
GLY A 614
VAL A 681
GLY A 655
ILE A 637
 None
C2E  A 919 (-3.4A)
None
None
None
 0.88A 6difB-5ej1A:
undetectable		 6difB-5ej1A:
7.14