SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '90V'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_A_URFA1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	4 / 6	ASN A 509 ILE A 500 SER A 505 ASN A 601	90V A 804 ( 4.6A) DMS A 805 (-4.9A) None 90V A 804 (-3.8A)	1.05A	1h7xA-6ek6A: undetectable	1h7xA-6ek6A: 6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_B_URFB1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	4 / 6	ASN A 509 ILE A 500 SER A 505 ASN A 601	90V A 804 ( 4.6A) DMS A 805 (-4.9A) None 90V A 804 (-3.8A)	1.05A	1h7xB-6ek6A: undetectable	1h7xB-6ek6A: 6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_C_URFC1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	4 / 6	ASN A 509 ILE A 500 SER A 505 ASN A 601	90V A 804 ( 4.6A) DMS A 805 (-4.9A) None 90V A 804 (-3.8A)	1.06A	1h7xC-6ek6A: undetectable	1h7xC-6ek6A: 6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_D_URFD1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	4 / 6	ASN A 509 ILE A 500 SER A 505 ASN A 601	90V A 804 ( 4.6A) DMS A 805 (-4.9A) None 90V A 804 (-3.8A)	1.06A	1h7xD-6ek6A: undetectable	1h7xD-6ek6A: 6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RUA_H_BEZH601_0 (IMMUNOGLOBULIN IGG2A, HEAVY CHAIN IMMUNOGLOBULIN IGG2A, LIGHT CHAIN)	6ek6	LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B (Homo sapiens)	5 / 10	ALA A 597 TRP A 519 LEU A 511 GLY A 576 PHE A 578	90V A 804 ( 4.5A) None None None None	1.39A	1ruaH-6ek6A: undetectable 1ruaL-6ek6A: undetectable	1ruaH-6ek6A: undetectable 1ruaL-6ek6A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H7X_A_URFA1033_1","DIHYDROPYRIMIDINE DEHYDROGENASE","6ek6","LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B","Homo sapiens",4,"ASN A 509;ILE A 500;SER A 505;ASN A 601","90V A 804 ( 4.6A);DMS A 805 (-4.9A);None;90V A 804 (-3.8A)","1.05A","1h7xA-6ek6A:undetectable",null],["1H7X_B_URFB1033_1","DIHYDROPYRIMIDINE DEHYDROGENASE","6ek6","LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B","Homo sapiens",4,"ASN A 509;ILE A 500;SER A 505;ASN A 601","90V A 804 ( 4.6A);DMS A 805 (-4.9A);None;90V A 804 (-3.8A)","1.05A","1h7xB-6ek6A:undetectable","1h7xA-6ek6A:6.26"],["1H7X_C_URFC1033_1","DIHYDROPYRIMIDINE DEHYDROGENASE","6ek6","LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B","Homo sapiens",4,"ASN A 509;ILE A 500;SER A 505;ASN A 601","90V A 804 ( 4.6A);DMS A 805 (-4.9A);None;90V A 804 (-3.8A)","1.06A","1h7xC-6ek6A:undetectable","1h7xB-6ek6A:6.26"],["1H7X_D_URFD1033_1","DIHYDROPYRIMIDINE DEHYDROGENASE","6ek6","LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B","Homo sapiens",4,"ASN A 509;ILE A 500;SER A 505;ASN A 601","90V A 804 ( 4.6A);DMS A 805 (-4.9A);None;90V A 804 (-3.8A)","1.06A","1h7xD-6ek6A:undetectable","1h7xC-6ek6A:6.26"],["1RUA_H_BEZH601_0","IMMUNOGLOBULIN IGG2A, HEAVY CHAIN;IMMUNOGLOBULIN IGG2A, LIGHT CHAIN","6ek6","LYSINE-SPECIFIC DEMETHYLASE 5B,LYSINE-SPECIFIC DEMETHYLASE 5B","Homo sapiens",5,"ALA A 597;TRP A 519;LEU A 511;GLY A 576;PHE A 578","90V A 804 ( 4.5A);None;None;None;None","1.39A","1ruaH-6ek6A:undetectable;1ruaL-6ek6A:undetectable","1h7xD-6ek6A:6.26"]]