SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8Z2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E22_B_LOCB700_2 (TUBULIN BETA-2B CHAIN)	5nji	PHTHIOCEROL/PHENOLPH THIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC (Mycobacterium tuberculosis)	5 / 11	LEU A1198 LEU A1132 ALA A1131 ALA A 973 VAL A1169	None 8Z2 A1301 ( 3.8A) None None None	1.13A	3e22B-5njiA: undetectable	3e22B-5njiA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E22_D_LOCD700_2 (TUBULIN BETA-2B CHAIN)	5nji	PHTHIOCEROL/PHENOLPH THIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC (Mycobacterium tuberculosis)	5 / 11	LEU A1198 LEU A1132 ALA A1131 ALA A 973 VAL A1169	None 8Z2 A1301 ( 3.8A) None None None	1.12A	3e22D-5njiA: undetectable	3e22D-5njiA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_C_VIAC901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	5nji	PHTHIOCEROL/PHENOLPH THIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC (Mycobacterium tuberculosis)	4 / 7	HIS A1086 MET A1214 LEU A 999 VAL A1196	8Z2 A1301 ( 4.7A) 8Z2 A1301 ( 3.1A) 8Z2 A1301 (-3.8A) None	0.98A	3jwqC-5njiA: undetectable	3jwqC-5njiA: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J14_A_X2NA602_1 (CHOLESTEROL 24-HYDROXYLASE)	5nji	PHTHIOCEROL/PHENOLPH THIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC (Mycobacterium tuberculosis)	5 / 10	ALA A1187 LEU A1192 VAL A1161 ALA A1145 THR A1142	None None 8Z2 A1301 (-3.3A) None None	0.94A	4j14A-5njiA: undetectable	4j14A-5njiA: 21.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3E22_B_LOCB700_2","TUBULIN BETA-2B CHAIN","5nji","PHTHIOCEROL\/PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC","Mycobacterium tuberculosis",5,"LEU A1198;LEU A1132;ALA A1131;ALA A 973;VAL A1169","None;8Z2 A1301 ( 3.8A);None;None;None","1.13A","3e22B-5njiA:undetectable",null],["3E22_D_LOCD700_2","TUBULIN BETA-2B CHAIN","5nji","PHTHIOCEROL\/PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC","Mycobacterium tuberculosis",5,"LEU A1198;LEU A1132;ALA A1131;ALA A 973;VAL A1169","None;8Z2 A1301 ( 3.8A);None;None;None","1.12A","3e22D-5njiA:undetectable","3e22B-5njiA:21.19"],["3JWQ_C_VIAC901_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA","5nji","PHTHIOCEROL\/PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC","Mycobacterium tuberculosis",4,"HIS A1086;MET A1214;LEU A 999;VAL A1196","8Z2 A1301 ( 4.7A);8Z2 A1301 ( 3.1A);8Z2 A1301 (-3.8A);None","0.98A","3jwqC-5njiA:undetectable","3e22D-5njiA:21.19"],["4J14_A_X2NA602_1","CHOLESTEROL 24-HYDROXYLASE","5nji","PHTHIOCEROL\/PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PPSC","Mycobacterium tuberculosis",5,"ALA A1187;LEU A1192;VAL A1161;ALA A1145;THR A1142","None;None;8Z2 A1301 (-3.3A);None;None","0.94A","4j14A-5njiA:undetectable","3jwqC-5njiA:22.52"]]