SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8Z1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoA-5v7iA:
51.5		 1dfoA-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoB-5v7iA:
51.9		 1dfoB-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoC-5v7iA:
51.9		 1dfoC-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoD-5v7iA:
51.6		 1dfoD-5v7iA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbA-5v7iA:
51.3		 1eqbA-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 166
GLY A 169
SER A 226
ALA A 227
ASN A 410
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 4.6A)
 0.99A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbC-5v7iA:
51.7		 1eqbC-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.24A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbD-5v7iA:
51.3		 1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.56A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A  76
HIS A 171
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.27A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.33A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 425
LEU A 381
THR A 281
 8Z1  A 601 ( 3.8A)
None
LLP  A 280 ( 3.9A)
 0.73A 3oxcA-5v7iA:
undetectable		 3oxcA-5v7iA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ARG A 425
LEU A 381
ASN A 379
VAL A 354
GLY A 257
 8Z1  A 601 ( 3.8A)
None
None
None
None
 1.14A 3spkA-5v7iA:
undetectable		 3spkA-5v7iA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.15A 4n09B-5v7iA:
4.6		 4n09B-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.14A 4n09D-5v7iA:
4.7		 4n09D-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ARG A 425
LEU A 381
ASN A 379
VAL A 354
GLY A 257
 8Z1  A 601 ( 3.8A)
None
None
None
None
 1.09A 5kqxB-5v7iA:
undetectable		 5kqxB-5v7iA:
12.72