SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8YP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P93_D_DEXD4999_1 (GLUCOCORTICOID RECEPTOR)	5u0l	N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE (Marinobacter hydrocarbonoclas ticus)	5 / 12	GLY A 453 CYH A 282 THR A 283 ILE A 430 PHE A 446	None EDO A 509 (-3.3A) EDO A 509 (-3.1A) None 8YP A 507 ( 3.5A)	1.45A	1p93D-5u0lA: undetectable	1p93D-5u0lA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA601_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	5u0l	N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE (Marinobacter hydrocarbonoclas ticus)	4 / 7	GLY A 158 ASN A 157 ALA A 163 VAL A 170	8YP A 507 (-2.9A) None None None	0.74A	3a2qA-5u0lA: undetectable	3a2qA-5u0lA: 24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Q_BEZQ801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5u0l	N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE (Marinobacter hydrocarbonoclas ticus)	4 / 5	SER A 458 ALA A 459 HIS A 159 LEU A 155	8YP A 507 (-2.3A) 8YP A 507 (-2.8A) 8YP A 507 (-3.1A) 8YP A 507 (-3.8A)	1.20A	5dzkc-5u0lA: undetectable 5dzkq-5u0lA: undetectable	5dzkc-5u0lA: 17.81 5dzkq-5u0lA: 2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_U_BEZU801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5u0l	N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE (Marinobacter hydrocarbonoclas ticus)	4 / 6	SER A 458 ALA A 459 HIS A 159 LEU A 155	8YP A 507 (-2.3A) 8YP A 507 (-2.8A) 8YP A 507 (-3.1A) 8YP A 507 (-3.8A)	1.23A	5dzkg-5u0lA: undetectable 5dzku-5u0lA: undetectable	5dzkg-5u0lA: 17.81 5dzku-5u0lA: 2.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P93_D_DEXD4999_1","GLUCOCORTICOID RECEPTOR","5u0l","N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE","Marinobacter hydrocarbonoclasticus",5,"GLY A 453;CYH A 282;THR A 283;ILE A 430;PHE A 446","None;EDO A 509 (-3.3A);EDO A 509 (-3.1A);None;8YP A 507 ( 3.5A)","1.45A","1p93D-5u0lA:undetectable",null],["3A2Q_A_ACAA601_1","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","5u0l","N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE","Marinobacter hydrocarbonoclasticus",4,"GLY A 158;ASN A 157;ALA A 163;VAL A 170","8YP A 507 (-2.9A);None;None;None","0.74A","3a2qA-5u0lA:undetectable","1p93D-5u0lA:21.14"],["5DZK_Q_BEZQ801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5u0l","N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE","Marinobacter hydrocarbonoclasticus",4,"SER A 458;ALA A 459;HIS A 159;LEU A 155","8YP A 507 (-2.3A);8YP A 507 (-2.8A);8YP A 507 (-3.1A);8YP A 507 (-3.8A)","1.20A","5dzkc-5u0lA:undetectable;5dzkq-5u0lA:undetectable","3a2qA-5u0lA:24.68"],["5DZK_U_BEZU801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","5u0l","N-SUCCINYLGLUTAMATE 5-SEMIALDEHYDE DEHYDROGENASE","Marinobacter hydrocarbonoclasticus",4,"SER A 458;ALA A 459;HIS A 159;LEU A 155","8YP A 507 (-2.3A);8YP A 507 (-2.8A);8YP A 507 (-3.1A);8YP A 507 (-3.8A)","1.23A","5dzkg-5u0lA:undetectable;5dzku-5u0lA:undetectable","5dzkc-5u0lA:17.81;5dzkq-5u0lA:2.41"]]