SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8X7'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWJ_A_BAXA1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239GLU A 259CYH A 292HIS A 337GLY A 379 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.8A)8X7 A 501 (-3.8A)NoneNone | 0.85A | 1uwjA-5vdkA:21.7 | 1uwjA-5vdkA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UWJ_B_BAXB1723_1 (B-RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 7 / 12 | ILE A 218VAL A 226ALA A 239GLU A 259CYH A 292HIS A 337GLY A 379 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.8A)8X7 A 501 (-3.8A)NoneNone | 0.97A | 1uwjB-5vdkA:21.7 | 1uwjB-5vdkA:28.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EVA_A_ADNA498_1 (TAK1 KINASE - TAB1CHIMERA FUSIONPROTEIN) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 11 | GLY A 219GLY A 221VAL A 226ALA A 239TYR A 291SER A 296 | 8X7 A 501 ( 3.8A)8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-4.2A)None | 0.55A | 2evaA-5vdkA:16.1 | 2evaA-5vdkA:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WGJ_A_VGHA2346_1 (HEPATOCYTE GROWTHFACTOR RECEPTOR) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | GLY A 219VAL A 226ALA A 239TYR A 291GLY A 295ASP A 380 | 8X7 A 501 ( 3.8A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A)8X7 A 501 (-4.8A) | 0.55A | 2wgjA-5vdkA:22.5 | 2wgjA-5vdkA:25.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G0E_A_B49A9000_1 (MAST/STEM CELLGROWTH FACTORRECEPTOR) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 11 | VAL A 226ALA A 239VAL A 273TYR A 291CYH A 292GLY A 295 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 ( 4.6A)8X7 A 501 (-4.2A)8X7 A 501 (-3.8A)8X7 A 501 (-3.6A) | 0.50A | 3g0eA-5vdkA:20.8 | 3g0eA-5vdkA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3MSS_D_STID1_2 (TYROSINE-PROTEINKINASE ABL1) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 4 / 6 | VAL A 226LYS A 241VAL A 273ILE A 287 | 8X7 A 501 ( 4.5A)PO4 A 502 (-3.6A)8X7 A 501 ( 4.6A)PO4 A 502 (-3.4A) | 0.65A | 3mssD-5vdkA:12.2 | 3mssD-5vdkA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OG7_A_032A1_1 (AKAP9-BRAF FUSIONPROTEIN) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | ILE A 218VAL A 226CYH A 292PHE A 346GLY A 382 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 4.5A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None | 0.78A | 3og7A-5vdkA:22.7 | 3og7A-5vdkA:28.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SXR_A_1N1A1_1 (CYTOPLASMICTYROSINE-PROTEINKINASE BMX) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239VAL A 273ILE A 287TYR A 291GLY A 295 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 ( 4.6A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A) | 0.42A | 3sxrA-5vdkA:17.8 | 3sxrA-5vdkA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3WZE_A_BAXA1201_2 (VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 4 / 8 | VAL A 272VAL A 273ILE A 378ASP A 380 | PO4 A 503 (-4.6A)8X7 A 501 ( 4.6A)None8X7 A 501 (-4.8A) | 0.36A | 3wzeA-5vdkA:22.5 | 3wzeA-5vdkA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4MXO_A_DB8A601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 7 / 12 | VAL A 226ALA A 239VAL A 273ILE A 287TYR A 291GLY A 295ASP A 380 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 ( 4.6A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A)8X7 A 501 (-4.8A) | 0.66A | 4mxoA-5vdkA:18.1 | 4mxoA-5vdkA:26.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4OGR_I_ADNI401_1 (CYCLIN-DEPENDENTKINASE 9) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 9 | ILE A 218GLY A 221VAL A 226ALA A 239CYH A 292ASN A 344 | 8X7 A 501 ( 4.0A)8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 ( 4.7A) | 0.76A | 4ogrI-5vdkA:26.0 | 4ogrI-5vdkA:23.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4QMN_A_DB8A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 7 / 12 | ILE A 218ALA A 239LYS A 241GLU A 259ILE A 287TYR A 291ASP A 380 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)PO4 A 502 (-3.8A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-4.8A) | 0.80A | 4qmnA-5vdkA:26.9 | 4qmnA-5vdkA:30.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4QMS_A_1N1A401_1 (SERINE/THREONINE-PROTEIN KINASE 24) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 11 | ILE A 218ALA A 239GLU A 259ILE A 287TYR A 291ASP A 380 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.8A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-4.8A) | 0.84A | 4qmsA-5vdkA:19.0 | 4qmsA-5vdkA:30.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_A_032A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | ALA A 239ILE A 287SER A 296PHE A 346GLY A 379 | 8X7 A 501 ( 3.7A)PO4 A 502 (-3.4A)None8X7 A 501 (-3.7A)None | 0.70A | 4rzvA-5vdkA:22.4 | 4rzvA-5vdkA:26.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239CYH A 292PHE A 346GLY A 379GLY A 382 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)NoneNone | 1.17A | 4rzvB-5vdkA:22.1 | 4rzvB-5vdkA:26.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4RZV_B_032B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239CYH A 292SER A 296PHE A 346GLY A 379 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)None8X7 A 501 (-3.7A)None | 0.91A | 4rzvB-5vdkA:22.1 | 4rzvB-5vdkA:26.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | VAL A 226ALA A 239CYH A 292PHE A 346GLY A 379 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None | 0.51A | 4xv2A-5vdkA:16.4 | 4xv2A-5vdkA:27.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4XV2_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | ALA A 239CYH A 292PHE A 346GLY A 379ASP A 380 | 8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None8X7 A 501 (-4.8A) | 0.74A | 4xv2B-5vdkA:22.8 | 4xv2B-5vdkA:27.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | VAL A 226ALA A 239CYH A 292PHE A 346GLY A 379 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None | 0.51A | 5cswA-5vdkA:22.2 | 5cswA-5vdkA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5CSW_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 5 / 12 | VAL A 226ALA A 239CYH A 292PHE A 346GLY A 379 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None | 0.55A | 5cswB-5vdkA:16.4 | 5cswB-5vdkA:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_A_P06A801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | GLY A 221VAL A 226ALA A 239ILE A 287PHE A 346GLY A 379 | 8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.4A)8X7 A 501 (-3.7A)None | 0.83A | 5hieA-5vdkA:22.0 | 5hieA-5vdkA:29.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_B_P06B801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | GLY A 221VAL A 226ALA A 239ILE A 287PHE A 346GLY A 379 | 8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.4A)8X7 A 501 (-3.7A)None | 0.86A | 5hieB-5vdkA:21.9 | 5hieB-5vdkA:29.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_C_P06C801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | GLY A 219GLY A 221VAL A 226ALA A 239PHE A 346GLY A 379 | 8X7 A 501 ( 3.8A)8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 (-3.7A)None | 0.81A | 5hieC-5vdkA:22.4 | 5hieC-5vdkA:29.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIE_D_P06D801_1 (SERINE/THREONINE-PROTEIN KINASE B-RAF) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | GLY A 221VAL A 226ALA A 239ILE A 287PHE A 346GLY A 379 | 8X7 A 501 (-3.4A)8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.4A)8X7 A 501 (-3.7A)None | 0.85A | 5hieD-5vdkA:22.1 | 5hieD-5vdkA:29.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5I9X_A_DB8A1001_1 (EPHRIN TYPE-ARECEPTOR 2) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | ILE A 218ALA A 239LYS A 241ILE A 287TYR A 291GLY A 295 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A) | 0.57A | 5i9xA-5vdkA:22.7 | 5i9xA-5vdkA:25.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 8 / 12 | GLU A 216ILE A 218ALA A 239GLU A 259TYR A 291GLY A 295PHE A 346ASP A 380 | 8X7 A 501 ( 4.9A)8X7 A 501 ( 4.0A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.8A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A)8X7 A 501 (-3.7A)8X7 A 501 (-4.8A) | 0.98A | 5vc3A-5vdkA:34.0 | 5vc3A-5vdkA:62.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 10 / 12 | GLU A 216ILE A 218GLY A 219ALA A 239ASN A 289TYR A 291CYH A 292GLY A 295PHE A 346ASP A 380 | 8X7 A 501 ( 4.9A)8X7 A 501 ( 4.0A)8X7 A 501 ( 3.8A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.2A)8X7 A 501 (-4.2A)8X7 A 501 (-3.8A)8X7 A 501 (-3.6A)8X7 A 501 (-3.7A)8X7 A 501 (-4.8A) | 0.69A | 5vc3A-5vdkA:34.0 | 5vc3A-5vdkA:62.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VC3_A_DB8A601_2 (WEE1-LIKE PROTEINKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 4 / 4 | VAL A 226LYS A 241VAL A 273ASN A 344 | 8X7 A 501 ( 4.5A)PO4 A 502 (-3.6A)8X7 A 501 ( 4.6A)8X7 A 501 ( 4.7A) | 0.44A | 5vc3A-5vdkA:34.0 | 5vc3A-5vdkA:62.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VCV_A_1N1A404_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 7 / 12 | ALA A 239LYS A 241GLU A 259VAL A 273GLY A 295PHE A 346GLY A 379 | 8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)PO4 A 502 (-3.8A)8X7 A 501 ( 4.6A)8X7 A 501 (-3.6A)8X7 A 501 (-3.7A)None | 1.02A | 5vcvA-5vdkA:30.8 | 5vcvA-5vdkA:31.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239LYS A 241CYH A 292GLY A 294PHE A 346 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)8X7 A 501 (-3.8A)None8X7 A 501 (-3.7A) | 0.76A | 5vcyA-5vdkA:30.3 | 5vcyA-5vdkA:31.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5VCY_A_DB8A401_1 (MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE) |
5vdk | WEE1-LIKE PROTEINKINASE 2 (Homosapiens) | 6 / 12 | VAL A 226ALA A 239LYS A 241GLU A 259CYH A 292PHE A 346 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)PO4 A 502 (-3.6A)PO4 A 502 (-3.8A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A) | 0.64A | 5vcyA-5vdkA:30.3 | 5vcyA-5vdkA:31.14 |