SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8WY'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UVN_A_ECNA1409_1 (CYTOCHROME P450 130)	5v4q	GAMMA-GLUTAMYLTRANSP EPTIDASE 1 LIGHT CHAIN (Homo sapiens)	6 / 12	LEU B 450 ASP B 422 THR B 475 GLY B 474 GLY B 473 THR B 381	None None None 8WY B1102 (-3.6A) 8WY B1102 (-3.7A) 8WY B1102 (-2.4A)	1.40A	2uvnA-5v4qB: undetectable	2uvnA-5v4qB: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	5v4q	GAMMA-GLUTAMYLTRANSP EPTIDASE 1 LIGHT CHAIN (Homo sapiens)	6 / 12	GLY B 473 ALA B 480 THR B 481 ARG B 503 GLU B 516 ALA B 382	8WY B1102 (-3.7A) None None None None CL B1103 (-3.8A)	1.47A	3g89A-5v4qB: undetectable	3g89A-5v4qB: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G89_B_SAMB303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	5v4q	GAMMA-GLUTAMYLTRANSP EPTIDASE 1 LIGHT CHAIN (Homo sapiens)	6 / 11	GLY B 473 ALA B 480 THR B 481 ARG B 503 GLU B 516 ALA B 382	8WY B1102 (-3.7A) None None None None CL B1103 (-3.8A)	1.34A	3g89B-5v4qB: undetectable	3g89B-5v4qB: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8B_A_SAMA303_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G)	5v4q	GAMMA-GLUTAMYLTRANSP EPTIDASE 1 LIGHT CHAIN (Homo sapiens)	6 / 12	GLY B 473 ALA B 480 THR B 481 ARG B 503 GLU B 516 ALA B 382	8WY B1102 (-3.7A) None None None None CL B1103 (-3.8A)	1.32A	3g8bA-5v4qB: undetectable	3g8bA-5v4qB: 23.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2UVN_A_ECNA1409_1","CYTOCHROME P450 130","5v4q","GAMMA-GLUTAMYLTRANSPEPTIDASE 1 LIGHT CHAIN","Homo sapiens",6,"LEU B 450;ASP B 422;THR B 475;GLY B 474;GLY B 473;THR B 381","None;None;None;8WY B1102 (-3.6A);8WY B1102 (-3.7A);8WY B1102 (-2.4A)","1.40A","2uvnA-5v4qB:undetectable",null],["3G89_A_SAMA303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","5v4q","GAMMA-GLUTAMYLTRANSPEPTIDASE 1 LIGHT CHAIN","Homo sapiens",6,"GLY B 473;ALA B 480;THR B 481;ARG B 503;GLU B 516;ALA B 382","8WY B1102 (-3.7A);None;None;None;None; CL B1103 (-3.8A)","1.47A","3g89A-5v4qB:undetectable","2uvnA-5v4qB:20.77"],["3G89_B_SAMB303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","5v4q","GAMMA-GLUTAMYLTRANSPEPTIDASE 1 LIGHT CHAIN","Homo sapiens",6,"GLY B 473;ALA B 480;THR B 481;ARG B 503;GLU B 516;ALA B 382","8WY B1102 (-3.7A);None;None;None;None; CL B1103 (-3.8A)","1.34A","3g89B-5v4qB:undetectable","3g89A-5v4qB:23.11"],["3G8B_A_SAMA303_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE G","5v4q","GAMMA-GLUTAMYLTRANSPEPTIDASE 1 LIGHT CHAIN","Homo sapiens",6,"GLY B 473;ALA B 480;THR B 481;ARG B 503;GLU B 516;ALA B 382","8WY B1102 (-3.7A);None;None;None;None; CL B1103 (-3.8A)","1.32A","3g8bA-5v4qB:undetectable","3g89B-5v4qB:23.11"]]