SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8WK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 GLY A 326
ASP A 346
GLN A 297
MET A 407
 None
None
8WK  A 601 (-3.2A)
8WK  A 601 (-3.9A)
 1.41A 3qx3A-5ngeA:
undetectable		 3qx3A-5ngeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 8 PHE A 409
ILE A 419
GLY A 458
ASN A 512
 8WK  A 601 (-3.8A)
None
None
None
 0.95A 4fgjA-5ngeA:
undetectable
4fgjB-5ngeA:
undetectable		 4fgjA-5ngeA:
22.06
4fgjB-5ngeA:
22.06