SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8W6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EI6_C_PPFC413_1 (PHOSPHONOACETATE HYDROLASE)	5yjp	HUMAN CHYMASE (Homo sapiens)	4 / 8	PHE A 228 THR A 229 ASP A 102 HIS A 57	None None 8W6 A 304 (-3.9A) 8W6 A 304 (-3.7A)	0.76A	1ei6C-5yjpA: undetectable	1ei6C-5yjpA: 9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_D_SAMD300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	5yjp	HUMAN CHYMASE (Homo sapiens)	6 / 12	GLY A 142 GLY A 44 GLY A 196 GLY A 193 THR A 54 LEU A 53	None None None 8W6 A 304 ( 4.1A) None None	1.44A	2oxtD-5yjpA: undetectable	2oxtD-5yjpA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_D_DVAD10_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	5yjp	HUMAN CHYMASE (Homo sapiens)	3 / 3	GLY A 193 GLY A 151 GLY A 142	8W6 A 304 ( 4.1A) None None	0.32A	3bogD-5yjpA: undetectable	3bogD-5yjpA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T01_A_PPFA503_1 (PHOSPHONOACETATE HYDROLASE)	5yjp	HUMAN CHYMASE (Homo sapiens)	4 / 7	PHE A 228 THR A 229 ASP A 102 HIS A 57	None None 8W6 A 304 (-3.9A) 8W6 A 304 (-3.7A)	0.89A	3t01A-5yjpA: undetectable	3t01A-5yjpA: 10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIW_C_SAMC4000_0 (NS5 METHYLTRANSFERASE)	5yjp	HUMAN CHYMASE (Homo sapiens)	6 / 12	GLY A 142 GLY A 44 GLY A 196 GLY A 193 THR A 54 VAL A 52	None None None 8W6 A 304 ( 4.1A) None None	1.30A	5eiwC-5yjpA: undetectable	5eiwC-5yjpA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EI6_C_PPFC413_1","PHOSPHONOACETATE HYDROLASE","5yjp","HUMAN CHYMASE","Homo sapiens",4,"PHE A 228;THR A 229;ASP A 102;HIS A  57","None;None;8W6 A 304 (-3.9A);8W6 A 304 (-3.7A)","0.76A","1ei6C-5yjpA:undetectable",null],["2OXT_D_SAMD300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","5yjp","HUMAN CHYMASE","Homo sapiens",6,"GLY A 142;GLY A  44;GLY A 196;GLY A 193;THR A  54;LEU A  53","None;None;None;8W6 A 304 ( 4.1A);None;None","1.44A","2oxtD-5yjpA:undetectable","1ei6C-5yjpA:9.83"],["3BOG_D_DVAD10_0","6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN","5yjp","HUMAN CHYMASE","Homo sapiens",3,"GLY A 193;GLY A 151;GLY A 142","8W6 A 304 ( 4.1A);None;None","0.32A","3bogD-5yjpA:undetectable","2oxtD-5yjpA:undetectable"],["3T01_A_PPFA503_1","PHOSPHONOACETATE HYDROLASE","5yjp","HUMAN CHYMASE","Homo sapiens",4,"PHE A 228;THR A 229;ASP A 102;HIS A  57","None;None;8W6 A 304 (-3.9A);8W6 A 304 (-3.7A)","0.89A","3t01A-5yjpA:undetectable","3bogD-5yjpA:undetectable"],["5EIW_C_SAMC4000_0","NS5 METHYLTRANSFERASE","5yjp","HUMAN CHYMASE","Homo sapiens",6,"GLY A 142;GLY A  44;GLY A 196;GLY A 193;THR A  54;VAL A  52","None;None;None;8W6 A 304 ( 4.1A);None;None","1.30A","5eiwC-5yjpA:undetectable","3t01A-5yjpA:10.53"]]