SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8VT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_A_SVRA508_1 (PHOSPHOLIPASE A2)	5nfb	GALECTIN-3 (Homo sapiens)	4 / 5	VAL A 172 PHE A 149 ARG A 186 ARG A 169	None None 8VT A 301 (-3.4A) None	1.43A	3bjwE-5nfbA: undetectable	3bjwE-5nfbA: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GAL_A_1GNA998_1 (GALECTIN-7)	5nfb	GALECTIN-3 (Homo sapiens)	6 / 6	HIS A 158 ASN A 160 ARG A 162 ASN A 174 TRP A 181 GLU A 184	8VT A 301 (-3.9A) 8VT A 301 (-4.0A) 8VT A 301 (-2.7A) 8VT A 301 (-3.8A) 8VT A 301 ( 3.7A) 8VT A 301 (-2.7A)	0.21A	3galA-5nfbA: 22.9	3galA-5nfbA: 29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GAL_B_1GNB999_1 (GALECTIN-7)	5nfb	GALECTIN-3 (Homo sapiens)	6 / 6	HIS A 158 ASN A 160 ARG A 162 ASN A 174 TRP A 181 GLU A 184	8VT A 301 (-3.9A) 8VT A 301 (-4.0A) 8VT A 301 (-2.7A) 8VT A 301 (-3.8A) 8VT A 301 ( 3.7A) 8VT A 301 (-2.7A)	0.29A	3galB-5nfbA: 23.1	3galB-5nfbA: 29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6B8K_A_W9TA300_0 (GALECTIN-3)	5nfb	GALECTIN-3 (Homo sapiens)	4 / 7	ARG A 186 ASN A 166 GLU A 165 ARG A 162	8VT A 301 (-3.4A) None 8VT A 301 (-3.5A) 8VT A 301 (-2.7A)	1.28A	6b8kA-5nfbA: 29.9	6b8kA-5nfbA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6B8K_A_W9TA300_0 (GALECTIN-3)	5nfb	GALECTIN-3 (Homo sapiens)	7 / 7	HIS A 158 ASN A 160 ARG A 162 ASN A 174 TRP A 181 GLU A 184 ARG A 186	8VT A 301 (-3.9A) 8VT A 301 (-4.0A) 8VT A 301 (-2.7A) 8VT A 301 (-3.8A) 8VT A 301 ( 3.7A) 8VT A 301 (-2.7A) 8VT A 301 (-3.4A)	0.09A	6b8kA-5nfbA: 29.9	6b8kA-5nfbA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6B94_A_W9TA201_0 (GALECTIN-1)	5nfb	GALECTIN-3 (Homo sapiens)	7 / 8	HIS A 158 ASN A 160 ARG A 162 ASN A 174 TRP A 181 GLU A 184 ARG A 186	8VT A 301 (-3.9A) 8VT A 301 (-4.0A) 8VT A 301 (-2.7A) 8VT A 301 (-3.8A) 8VT A 301 ( 3.7A) 8VT A 301 (-2.7A) 8VT A 301 (-3.4A)	0.48A	6b94A-5nfbA: 19.8	6b94A-5nfbA: 37.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6B94_B_W9TB201_0 (GALECTIN-1)	5nfb	GALECTIN-3 (Homo sapiens)	7 / 10	HIS A 158 ASN A 160 ARG A 162 ASN A 174 TRP A 181 GLU A 184 ARG A 186	8VT A 301 (-3.9A) 8VT A 301 (-4.0A) 8VT A 301 (-2.7A) 8VT A 301 (-3.8A) 8VT A 301 ( 3.7A) 8VT A 301 (-2.7A) 8VT A 301 (-3.4A)	0.34A	6b94A-5nfbA: 19.8 6b94B-5nfbA: 19.4	6b94A-5nfbA: 37.63 6b94B-5nfbA: 37.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FK2_A_SORA302_0 (GALECTIN-3)	5nfb	GALECTIN-3 (Homo sapiens)	4 / 4	ARG A 162 GLU A 165 GLU A 184 ARG A 186	8VT A 301 (-2.7A) 8VT A 301 (-3.5A) 8VT A 301 (-2.7A) 8VT A 301 (-3.4A)	0.07A	6fk2A-5nfbA: 29.8	6fk2A-5nfbA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6FK2_A_SORA302_0 (GALECTIN-3)	5nfb	GALECTIN-3 (Homo sapiens)	4 / 4	ARG A 186 GLU A 184 GLU A 165 ARG A 162	8VT A 301 (-3.4A) 8VT A 301 (-2.7A) 8VT A 301 (-3.5A) 8VT A 301 (-2.7A)	1.06A	6fk2A-5nfbA: 29.8	6fk2A-5nfbA: 100.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3BJW_A_SVRA508_1","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","5nfb","GALECTIN-3","Homo sapiens",4,"VAL A 172;PHE A 149;ARG A 186;ARG A 169","None;None;8VT A 301 (-3.4A);None","1.43A","3bjwE-5nfbA:undetectable",null],["3GAL_A_1GNA998_1","GALECTIN-7","5nfb","GALECTIN-3","Homo sapiens",6,"HIS A 158;ASN A 160;ARG A 162;ASN A 174;TRP A 181;GLU A 184","8VT A 301 (-3.9A);8VT A 301 (-4.0A);8VT A 301 (-2.7A);8VT A 301 (-3.8A);8VT A 301 ( 3.7A);8VT A 301 (-2.7A)","0.21A","3galA-5nfbA:22.9","3bjwE-5nfbA:19.76"],["3GAL_B_1GNB999_1","GALECTIN-7","5nfb","GALECTIN-3","Homo sapiens",6,"HIS A 158;ASN A 160;ARG A 162;ASN A 174;TRP A 181;GLU A 184","8VT A 301 (-3.9A);8VT A 301 (-4.0A);8VT A 301 (-2.7A);8VT A 301 (-3.8A);8VT A 301 ( 3.7A);8VT A 301 (-2.7A)","0.29A","3galB-5nfbA:23.1","3galA-5nfbA:29.55"],["6B8K_A_W9TA300_0","GALECTIN-3","5nfb","GALECTIN-3","Homo sapiens",4,"ARG A 186;ASN A 166;GLU A 165;ARG A 162","8VT A 301 (-3.4A);None;8VT A 301 (-3.5A);8VT A 301 (-2.7A)","1.28A","6b8kA-5nfbA:29.9","3galB-5nfbA:29.55"],["6B8K_A_W9TA300_0","GALECTIN-3","5nfb","GALECTIN-3","Homo sapiens",7,"HIS A 158;ASN A 160;ARG A 162;ASN A 174;TRP A 181;GLU A 184;ARG A 186","8VT A 301 (-3.9A);8VT A 301 (-4.0A);8VT A 301 (-2.7A);8VT A 301 (-3.8A);8VT A 301 ( 3.7A);8VT A 301 (-2.7A);8VT A 301 (-3.4A)","0.09A","6b8kA-5nfbA:29.9","6b8kA-5nfbA:100.00"],["6B94_A_W9TA201_0","GALECTIN-1","5nfb","GALECTIN-3","Homo sapiens",7,"HIS A 158;ASN A 160;ARG A 162;ASN A 174;TRP A 181;GLU A 184;ARG A 186","8VT A 301 (-3.9A);8VT A 301 (-4.0A);8VT A 301 (-2.7A);8VT A 301 (-3.8A);8VT A 301 ( 3.7A);8VT A 301 (-2.7A);8VT A 301 (-3.4A)","0.48A","6b94A-5nfbA:19.8","6b8kA-5nfbA:100.00"],["6B94_B_W9TB201_0","GALECTIN-1","5nfb","GALECTIN-3","Homo sapiens",7,"HIS A 158;ASN A 160;ARG A 162;ASN A 174;TRP A 181;GLU A 184;ARG A 186","8VT A 301 (-3.9A);8VT A 301 (-4.0A);8VT A 301 (-2.7A);8VT A 301 (-3.8A);8VT A 301 ( 3.7A);8VT A 301 (-2.7A);8VT A 301 (-3.4A)","0.34A","6b94A-5nfbA:19.8;6b94B-5nfbA:19.4","6b94A-5nfbA:37.63"],["6FK2_A_SORA302_0","GALECTIN-3","5nfb","GALECTIN-3","Homo sapiens",4,"ARG A 162;GLU A 165;GLU A 184;ARG A 186","8VT A 301 (-2.7A);8VT A 301 (-3.5A);8VT A 301 (-2.7A);8VT A 301 (-3.4A)","0.07A","6fk2A-5nfbA:29.8","6b94A-5nfbA:37.63;6b94B-5nfbA:37.63"],["6FK2_A_SORA302_0","GALECTIN-3","5nfb","GALECTIN-3","Homo sapiens",4,"ARG A 186;GLU A 184;GLU A 165;ARG A 162","8VT A 301 (-3.4A);8VT A 301 (-2.7A);8VT A 301 (-3.5A);8VT A 301 (-2.7A)","1.06A","6fk2A-5nfbA:29.8","6fk2A-5nfbA:100.00"]]