SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8UN'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5ndz	LYSOZYME,PROTEINASE- ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Escherichia virus T4; Homo sapiens)	4 / 7	GLN A 214 TYR A 210 TYR A 160 ILE A 202	None 8UN A2201 (-3.9A) None 8UN A2201 ( 4.6A)	1.05A	2ph9A-5ndzA: undetectable 2ph9B-5ndzA: undetectable	2ph9A-5ndzA: 16.19 2ph9B-5ndzA: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5ndz	LYSOZYME,PROTEINASE- ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Escherichia virus T4; Homo sapiens)	4 / 7	TYR A 242 GLN A 214 TYR A 160 ILE A 202	None None None 8UN A2201 ( 4.6A)	1.21A	2ph9A-5ndzA: undetectable 2ph9B-5ndzA: undetectable	2ph9A-5ndzA: 16.19 2ph9B-5ndzA: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZDY_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5ndz	LYSOZYME,PROTEINASE- ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Escherichia virus T4; Homo sapiens)	3 / 3	ALA A 157 TYR A 160 PRO A 208	8UN A2201 (-3.2A) None None	0.64A	4zdyA-5ndzA: undetectable	4zdyA-5ndzA: 22.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PH9_A_GNTA301_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","5ndz","LYSOZYME,PROTEINASE-ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTIVATED RECEPTOR 2","Escherichia coli;Escherichia virus T4;Homo sapiens",4,"GLN A 214;TYR A 210;TYR A 160;ILE A 202","None;8UN A2201 (-3.9A);None;8UN A2201 ( 4.6A)","1.05A","2ph9A-5ndzA:undetectable;2ph9B-5ndzA:undetectable",null],["2PH9_A_GNTA301_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","5ndz","LYSOZYME,PROTEINASE-ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTIVATED RECEPTOR 2","Escherichia coli;Escherichia virus T4;Homo sapiens",4,"TYR A 242;GLN A 214;TYR A 160;ILE A 202","None;None;None;8UN A2201 ( 4.6A)","1.21A","2ph9A-5ndzA:undetectable;2ph9B-5ndzA:undetectable","2ph9A-5ndzA:16.19;2ph9B-5ndzA:16.19"],["4ZDY_A_1YNA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","5ndz","LYSOZYME,PROTEINASE-ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTIVATED RECEPTOR 2","Escherichia coli;Escherichia virus T4;Homo sapiens",3,"ALA A 157;TYR A 160;PRO A 208","8UN A2201 (-3.2A);None;None","0.64A","4zdyA-5ndzA:undetectable","2ph9A-5ndzA:16.19;2ph9B-5ndzA:16.19"]]