SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8U8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HO5_A_ADNA1604_1 (5'-NUCLEOTIDASE)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	5 / 11	SER A 218 GLY A 181 GLY A 183 PHE A 93 ASP A 264	None None None 8U8 A 713 (-4.1A) None	1.47A	1ho5A-5ndxA: 2.7	1ho5A-5ndxA: 9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N2O_C_AG2C1002_1 (BIOSYNTHETIC ARGININE DECARBOXYLASE)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	4 / 8	HIS A 279 LEU A 310 ASP A 267 ASP A 313	None None 8U8 A 712 ( 4.8A) 8U8 A 712 (-3.6A)	1.25A	3n2oC-5ndxA: 8.3 3n2oD-5ndxA: 2.3	3n2oC-5ndxA: 8.25 3n2oD-5ndxA: 8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_1 (16S RRNA METHYLASE)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	3 / 3	ASP A 313 GLU A 142 SER A 273	8U8 A 712 (-3.6A) None None	0.85A	3p2kA-5ndxA: undetectable	3p2kA-5ndxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R94_A_FLRA332_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	5 / 12	LEU A 61 TYR A 62 TRP A 139 PHE A 141 TYR A 216	None None None None 8U8 A 713 (-3.8A)	1.45A	3r94A-5ndxA: 7.7	3r94A-5ndxA: 12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_B_1LDB501_0 (CYTOSINE DEAMINASE)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	5 / 12	HIS A 220 GLU A 95 GLU A 142 ASP A 264 SER A 218	8U8 A 712 ( 4.7A) None None None None	1.41A	4r88B-5ndxA: 6.1	4r88B-5ndxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R88_F_1LDF502_0 (CYTOSINE DEAMINASE)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	5 / 12	HIS A 220 GLU A 95 GLU A 142 ASP A 264 SER A 218	8U8 A 712 ( 4.7A) None None None None	1.41A	4r88F-5ndxA: 4.1	4r88F-5ndxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CZY_A_SAMA603_0 (LEGIONELLA EFFECTOR LEGAS4)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	5 / 12	LEU A 48 GLY A 52 ARG A 23 SER A 410 LEU A 366	None None 8U8 A 713 ( 3.7A) None None	1.19A	5czyA-5ndxA: 1.5	5czyA-5ndxA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KIR_B_RCXB601_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	4 / 4	LEU A 310 ARG A 23 ILE A 292 PHE A 21	None 8U8 A 713 ( 3.7A) None None	1.35A	5kirB-5ndxA: undetectable	5kirB-5ndxA: 9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_F_CCSF14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	5ndx	GLYCOSYL HYDROLASE (Rhizobium leguminosarum)	4 / 6	PHE A 55 SER A 311 ARG A 57 GLY A 26	8U8 A 713 (-3.9A) None None None	1.14A	5o4yF-5ndxA: undetectable	5o4yF-5ndxA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HO5_A_ADNA1604_1","5'-NUCLEOTIDASE","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",5,"SER A 218;GLY A 181;GLY A 183;PHE A  93;ASP A 264","None;None;None;8U8 A 713 (-4.1A);None","1.47A","1ho5A-5ndxA:2.7",null],["3N2O_C_AG2C1002_1","BIOSYNTHETIC ARGININE DECARBOXYLASE;BIOSYNTHETIC ARGININE DECARBOXYLASE","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",4,"HIS A 279;LEU A 310;ASP A 267;ASP A 313","None;None;8U8 A 712 ( 4.8A);8U8 A 712 (-3.6A)","1.25A","3n2oC-5ndxA:8.3;3n2oD-5ndxA:2.3","1ho5A-5ndxA:9.55"],["3P2K_A_SAMA6735_1","16S RRNA METHYLASE","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",3,"ASP A 313;GLU A 142;SER A 273","8U8 A 712 (-3.6A);None;None","0.85A","3p2kA-5ndxA:undetectable","3n2oC-5ndxA:8.25;3n2oD-5ndxA:8.25"],["3R94_A_FLRA332_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",5,"LEU A  61;TYR A  62;TRP A 139;PHE A 141;TYR A 216","None;None;None;None;8U8 A 713 (-3.8A)","1.45A","3r94A-5ndxA:7.7","3p2kA-5ndxA:undetectable"],["4R88_B_1LDB501_0","CYTOSINE DEAMINASE","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",5,"HIS A 220;GLU A  95;GLU A 142;ASP A 264;SER A 218","8U8 A 712 ( 4.7A);None;None;None;None","1.41A","4r88B-5ndxA:6.1","3r94A-5ndxA:12.29"],["4R88_F_1LDF502_0","CYTOSINE DEAMINASE","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",5,"HIS A 220;GLU A  95;GLU A 142;ASP A 264;SER A 218","8U8 A 712 ( 4.7A);None;None;None;None","1.41A","4r88F-5ndxA:4.1","4r88B-5ndxA:undetectable"],["5CZY_A_SAMA603_0","LEGIONELLA EFFECTOR LEGAS4","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",5,"LEU A  48;GLY A  52;ARG A  23;SER A 410;LEU A 366","None;None;8U8 A 713 ( 3.7A);None;None","1.19A","5czyA-5ndxA:1.5","4r88F-5ndxA:undetectable"],["5KIR_B_RCXB601_2","PROSTAGLANDIN G\/H SYNTHASE 2","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",4,"LEU A 310;ARG A  23;ILE A 292;PHE A  21","None;8U8 A 713 ( 3.7A);None;None","1.35A","5kirB-5ndxA:undetectable","5czyA-5ndxA:undetectable"],["5O4Y_F_CCSF14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","5ndx","GLYCOSYL HYDROLASE","Rhizobium leguminosarum",4,"PHE A  55;SER A 311;ARG A  57;GLY A  26","8U8 A 713 (-3.9A);None;None;None","1.14A","5o4yF-5ndxA:undetectable","5kirB-5ndxA:9.50"]]