SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8ST'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
ALA A 859
VAL A 892
ASN A1027
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
None
None
 0.77A 1fmoE-3hngA:
21.3		 1fmoE-3hngA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
ASN A1027
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
None
 0.66A 1fmoE-3hngA:
21.3		 1fmoE-3hngA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.70A 1iepA-3hngA:
33.3		 1iepA-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.92A 1iepB-3hngA:
33.2		 1iepB-3hngA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 833
GLY A 834
VAL A 841
ALA A 859
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
 0.56A 1muoA-3hngA:
18.2		 1muoA-3hngA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
 0.70A 1opjA-3hngA:
32.8		 1opjA-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.81A 1opjA-3hngA:
32.8		 1opjA-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
GLY A 915
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.75A 1opjB-3hngA:
32.9		 1opjB-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 892
GLY A 915
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
None
8ST  A2001 ( 3.7A)
 0.61A 1t46A-3hngA:
41.9		 1t46A-3hngA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 7 VAL A 907
TYR A 911
CYH A 912
CYH A1039
 8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.2A)
 0.38A 1t46A-3hngA:
41.9		 1t46A-3hngA:
48.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.45A 1uwhA-3hngA:
29.4		 1uwhA-3hngA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.50A 1uwhB-3hngA:
29.2		 1uwhB-3hngA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 841
ALA A 859
GLU A 878
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.61A 1uwjA-3hngA:
8.2		 1uwjA-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 841
ALA A 859
GLU A 878
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.61A 1uwjB-3hngA:
27.9		 1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		3 / 3 ILE A1028
ASP A1040
PHE A1041
 None
None
8ST  A2001 ( 3.7A)
 0.65A 1uwjB-3hngA:
27.9		 1uwjB-3hngA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 833
GLY A 834
VAL A 841
ALA A 859
TYR A 911
ASN A1027
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
 0.73A 2fumC-3hngA:
24.1		 2fumC-3hngA:
23.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.94A 2hyyA-3hngA:
33.2		 2hyyA-3hngA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.93A 2hyyB-3hngA:
33.7		 2hyyB-3hngA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
None
 0.87A 2hyyC-3hngA:
33.4		 2hyyC-3hngA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.97A 2hyyD-3hngA:
33.8		 2hyyD-3hngA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
GLY A 834
VAL A 841
LYS A 861
GLU A 878
LEU A 882
VAL A 909
TYR A 911
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
 0.36A 2ivuA-3hngA:
32.4		 2ivuA-3hngA:
42.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
TYR A 911
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
None
 0.73A 2oiqA-3hngA:
31.0		 2oiqA-3hngA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LYS A 831
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
LEU A1029
 None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
 0.87A 2y6oA-3hngA:
31.9		 2y6oA-3hngA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 833
GLY A 834
ALA A 859
LYS A 861
VAL A 892
VAL A 909
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
None
 0.47A 3c7qA-3hngA:
36.8		 3c7qA-3hngA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 833
GLY A 834
ALA A 859
VAL A 892
VAL A 909
CYH A 912
GLY A 915
LEU A1029
CYH A1039
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.60A 3c7qA-3hngA:
36.8		 3c7qA-3hngA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 10 LEU A 833
VAL A 841
LYS A 861
VAL A 892
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
None
 0.95A 3cs9A-3hngA:
33.1		 3cs9A-3hngA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 859
GLU A 878
GLY A 915
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
 0.75A 3cs9B-3hngA:
31.1		 3cs9B-3hngA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 9 LEU A 833
VAL A 841
LYS A 861
VAL A 892
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
None
 0.75A 3cs9B-3hngA:
31.1		 3cs9B-3hngA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 6 LEU A 833
VAL A 841
LYS A 861
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
None
None
 0.95A 3cs9D-3hngA:
31.7		 3cs9D-3hngA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.52A 3fupB-3hngA:
29.1		 3fupB-3hngA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 11 LEU A 833
VAL A 841
ALA A 859
VAL A 892
TYR A 911
CYH A 912
GLY A 915
LEU A1029
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.53A 3g0eA-3hngA:
38.5		 3g0eA-3hngA:
46.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 833
VAL A 841
ALA A 859
CYH A 912
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.81A 3g0fA-3hngA:
40.3		 3g0fA-3hngA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 833
VAL A 841
ALA A 859
TYR A 911
CYH A 912
GLY A 915
LEU A1029
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.60A 3g0fA-3hngA:
40.3		 3g0fA-3hngA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 10 LEU A 833
VAL A 841
ALA A 859
CYH A 912
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.73A 3g0fB-3hngA:
40.0		 3g0fB-3hngA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 10 LEU A 833
VAL A 841
ALA A 859
TYR A 911
CYH A 912
GLY A 915
LEU A1029
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.58A 3g0fB-3hngA:
40.0		 3g0fB-3hngA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.58A 3g5dA-3hngA:
29.8		 3g5dA-3hngA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.85A 3g5dB-3hngA:
29.8		 3g5dB-3hngA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.72A 3g5dB-3hngA:
29.8		 3g5dB-3hngA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
LEU A 882
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.76A 3gp0A-3hngA:
22.6		 3gp0A-3hngA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.86A 3gvuA-3hngA:
32.9		 3gvuA-3hngA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 859
GLU A 878
LEU A 882
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 ( 3.7A)
 0.67A 3hecA-3hngA:
20.9		 3hecA-3hngA:
26.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.92A 3ik3A-3hngA:
32.3		 3ik3A-3hngA:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.93A 3ik3B-3hngA:
33.0		 3ik3B-3hngA:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.80A 3k54A-3hngA:
29.7		 3k54A-3hngA:
32.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.86A 3k5vA-3hngA:
32.7		 3k5vA-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.86A 3k5vB-3hngA:
32.5		 3k5vB-3hngA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
VAL A 892
TYR A 911
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
 0.67A 3lxkA-3hngA:
29.6		 3lxkA-3hngA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-4.9A)
None
 0.60A 3lxnA-3hngA:
28.6		 3lxnA-3hngA:
27.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.91A 3ms9A-3hngA:
32.8		 3ms9A-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.85A 3ms9B-3hngA:
33.2		 3ms9B-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.91A 3mssA-3hngA:
33.1		 3mssA-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.74A 3mssB-3hngA:
33.1		 3mssB-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.94A 3mssC-3hngA:
33.0		 3mssC-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
ALA A 859
GLU A 878
ILE A 885
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
None
 0.89A 3mssD-3hngA:
33.1		 3mssD-3hngA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.66A 3octA-3hngA:
29.6		 3octA-3hngA:
32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLU A 878
ILE A 885
VAL A 892
TYR A 911
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
None
 0.80A 3oezA-3hngA:
30.6		 3oezA-3hngA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
GLU A 878
ILE A 885
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.6A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.82A 3oezA-3hngA:
30.6		 3oezA-3hngA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 841
ALA A 859
LYS A 861
LEU A 882
CYH A 912
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
8ST  A2001 (-3.8A)
 0.68A 3og7A-3hngA:
26.6		 3og7A-3hngA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 834
VAL A 841
ALA A 859
LYS A 861
LEU A 882
ASN A 919
 None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
 0.79A 3ohtA-3hngA:
16.5		 3ohtA-3hngA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
GLY A 915
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.90A 3oxzA-3hngA:
31.5		 3oxzA-3hngA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
GLU A 878
ILE A 885
VAL A 892
GLY A 915
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.8A)
None
 0.82A 3oxzA-3hngA:
31.5		 3oxzA-3hngA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.80A 3pyyB-3hngA:
31.2		 3pyyB-3hngA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.89A 3qlgA-3hngA:
25.2		 3qlgA-3hngA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.78A 3qlgB-3hngA:
29.8		 3qlgB-3hngA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
LEU A 882
TYR A 911
LEU A1013
HIS A1020
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.78A 3rgfA-3hngA:
7.8		 3rgfA-3hngA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.64A 3sxrA-3hngA:
29.0		 3sxrA-3hngA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.62A 3sxrB-3hngA:
28.9		 3sxrB-3hngA:
33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
ALA A 859
GLU A 878
LEU A 882
VAL A 909
CYH A1039
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.2A)
 0.87A 3wzdA-3hngA:
35.2		 3wzdA-3hngA:
67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
LEU A 882
VAL A 909
CYH A 912
GLY A 915
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
8ST  A2001 (-4.2A)
 0.52A 3wzdA-3hngA:
35.2		 3wzdA-3hngA:
67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 5 LYS A 861
ILE A 881
VAL A 892
LEU A1029
 8ST  A2001 (-4.0A)
None
8ST  A2001 ( 4.7A)
None
 0.84A 3wzdA-3hngA:
35.2		 3wzdA-3hngA:
67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
ILE A 885
VAL A 909
GLY A 915
LEU A1013
HIS A1020
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 (-4.1A)
None
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.64A 3wzeA-3hngA:
43.3		 3wzeA-3hngA:
67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 8 VAL A 891
VAL A 892
CYH A 912
LEU A1029
ILE A1038
CYH A1039
ASP A1040
PHE A1041
 None
8ST  A2001 ( 4.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
None
8ST  A2001 ( 3.7A)
 0.54A 3wzeA-3hngA:
43.3		 3wzeA-3hngA:
67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 LEU A 833
ALA A 859
LYS A 861
GLU A 878
LEU A1013
HIS A1020
ARG A1021
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
None
None
8ST  A2001 ( 3.7A)
 0.71A 3zosA-3hngA:
33.2		 3zosA-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 859
LYS A 861
GLU A 878
LEU A1013
HIS A1020
ARG A1021
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
None
None
8ST  A2001 ( 3.7A)
 0.73A 3zosB-3hngA:
33.6		 3zosB-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 892
VAL A 909
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.47A 4ag8A-3hngA:
43.5		 4ag8A-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 909
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.51A 4agcA-3hngA:
42.0		 4agcA-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 11 LEU A 833
ALA A 859
LYS A 861
VAL A 892
VAL A 909
CYH A 912
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.68A 4agdA-3hngA:
41.4		 4agdA-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 11 LEU A 833
ALA A 859
VAL A 892
VAL A 909
CYH A 912
GLY A 915
LEU A1029
CYH A1039
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
 0.60A 4agdA-3hngA:
41.4		 4agdA-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 909
GLY A 915
LEU A1013
HIS A1020
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
None
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
8ST  A2001 ( 3.7A)
 0.49A 4asdA-3hngA:
44.3		 4asdA-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 6 ILE A 885
VAL A 892
CYH A 912
LEU A1029
ILE A1038
CYH A1039
 None
8ST  A2001 ( 4.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
 0.54A 4asdA-3hngA:
44.3		 4asdA-3hngA:
67.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 881
TYR A 911
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
None
None
 0.93A 4bkjA-3hngA:
32.6		 4bkjA-3hngA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 881
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.73A 4bkjB-3hngA:
32.7		 4bkjB-3hngA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.79A 4c8bA-3hngA:
26.3		 4c8bA-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
LEU A 882
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
None
 0.71A 4c8bA-3hngA:
26.3		 4c8bA-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.83A 4c8bB-3hngA:
25.9		 4c8bB-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
LEU A 882
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
None
 0.77A 4c8bB-3hngA:
25.9		 4c8bB-3hngA:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 909
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
None
 0.68A 4ckiA-3hngA:
32.4		 4ckiA-3hngA:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 10 LEU A 833
GLY A 834
GLY A 836
VAL A 841
ALA A 859
VAL A 909
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
 0.55A 4ckjA-3hngA:
33.0		 4ckjA-3hngA:
42.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
GLU A 878
ILE A 881
TYR A 911
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
None
None
8ST  A2001 ( 3.7A)
 0.85A 4csvA-3hngA:
32.0		 4csvA-3hngA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 881
VAL A 892
TYR A 911
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.72A 4csvA-3hngA:
32.0		 4csvA-3hngA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 834
VAL A 841
ALA A 859
LEU A 894
GLY A 915
LEU A1029
 None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
None
None
None
 0.46A 4ifgA-3hngA:
16.9		 4ifgA-3hngA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A1088
LEU A1089
LEU A1150
ILE A1038
HIS A1020
 None
None
None
None
8ST  A2001 ( 4.8A)
 0.91A 4j24A-3hngA:
undetectable		 4j24A-3hngA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU A1088
LEU A1089
LEU A1150
ILE A1038
HIS A1020
 None
None
None
None
8ST  A2001 ( 4.8A)
 0.94A 4j24B-3hngA:
undetectable		 4j24B-3hngA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
None
 0.77A 4mkcA-3hngA:
30.4		 4mkcA-3hngA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.95A 4mxxB-3hngA:
29.3		 4mxxB-3hngA:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 11 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LYS A 861
ASN A1027
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
 0.70A 4o0sA-3hngA:
24.0		 4o0sA-3hngA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 6 VAL A 841
ALA A 859
LYS A 861
LEU A1029
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
 0.65A 4o0uA-3hngA:
8.7		 4o0uA-3hngA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 6 LEU A 833
GLY A 834
VAL A 841
ALA A 859
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
None
 0.48A 4o0wA-3hngA:
24.0		 4o0wA-3hngA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
GLY A 834
GLY A 839
VAL A 841
ALA A 859
VAL A 892
LEU A1029
 8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
 0.50A 4otiA-3hngA:
19.2		 4otiA-3hngA:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
LYS A 861
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.84A 4otwA-3hngA:
28.2		 4otwA-3hngA:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 859
GLU A 878
VAL A 909
ARG A1021
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
None
 1.04A 4qrcA-3hngA:
35.1		 4qrcA-3hngA:
45.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 859
GLU A 878
VAL A 909
ARG A1021
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
8ST  A2001 ( 3.7A)
 1.01A 4qrcA-3hngA:
35.1		 4qrcA-3hngA:
45.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
ARG A1021
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
None
 0.73A 4qrcA-3hngA:
35.1		 4qrcA-3hngA:
45.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
CYH A1018
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 3.7A)
 0.55A 4r7iA-3hngA:
42.0		 4r7iA-3hngA:
44.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 5 LEU A 833
VAL A 892
VAL A 907
TYR A 911
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
 0.33A 4r7iA-3hngA:
42.0		 4r7iA-3hngA:
44.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLY A 915
ASN A1027
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
None
None
 0.69A 4twpA-3hngA:
30.6		 4twpA-3hngA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLY A 915
ASN A1027
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
None
None
 0.76A 4twpB-3hngA:
30.9		 4twpB-3hngA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 859
GLU A 878
ILE A 885
VAL A 909
CYH A1018
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
 0.88A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 859
GLU A 878
VAL A 909
CYH A1018
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.92A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ILE A 881
VAL A 907
ALA A 859
CYH A1018
HIS A1020
ASP A1040
 None
8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.40A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ILE A 885
VAL A 907
ALA A 859
CYH A1018
HIS A1020
ASP A1040
 None
8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.47A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 10 LEU A 833
VAL A 841
GLU A 878
VAL A 892
VAL A 907
TYR A 911
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
None
 0.48A 4u0iA-3hngA:
41.4		 4u0iA-3hngA:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 ALA A 859
LYS A 861
LEU A 882
CYH A 912
GLY A 915
CYH A1018
HIS A1020
LEU A1029
CYH A1039
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
8ST  A2001 (-3.8A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
8ST  A2001 (-4.2A)
None
8ST  A2001 ( 3.7A)
 0.57A 4u0iA-3hngA:
41.4		 4u0iA-3hngA:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 9 LEU A 833
VAL A 841
ALA A 859
TYR A 911
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
None
None
 0.87A 4u5jB-3hngA:
30.0		 4u5jB-3hngA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 833
ALA A 859
GLU A 878
VAL A 909
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
None
 0.82A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
ALA A 859
ILE A 885
VAL A 909
LEU A1013
CYH A1018
HIS A1020
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
 0.85A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
VAL A 909
LEU A1013
CYH A1018
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
 0.68A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
GLU A 878
ILE A 885
VAL A 909
LEU A1013
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
 0.71A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
VAL A 909
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.86A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 833
VAL A 841
TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.9A)
None
None
None
 0.79A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.50A 4v01B-3hngA:
34.7		 4v01B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 907
ALA A 859
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.16A 4v01B-3hngA:
34.7		 4v01B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 9 LEU A 833
VAL A 841
LYS A 861
ILE A 885
TYR A 911
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
None
8ST  A2001 (-4.9A)
None
None
 0.67A 4v01B-3hngA:
34.7		 4v01B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 841
ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.60A 4v04A-3hngA:
34.2		 4v04A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 8 TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 (-4.9A)
None
None
None
 0.66A 4v04A-3hngA:
34.2		 4v04A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 10 LEU A 833
VAL A 841
LYS A 861
TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-4.9A)
None
None
None
 0.76A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 859
GLU A 878
VAL A 909
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
8ST  A2001 ( 3.7A)
 0.75A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.43A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
ALA A 859
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.63A 4xliA-3hngA:
31.4		 4xliA-3hngA:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.72A 4xliB-3hngA:
30.9		 4xliB-3hngA:
34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
 0.62A 5bvwA-3hngA:
32.5		 5bvwA-3hngA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 859
LYS A 861
GLU A 878
LEU A 882
CYH A 912
LEU A1013
HIS A1020
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
 0.53A 5hi2A-3hngA:
28.3		 5hi2A-3hngA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 7 GLY A 834
GLY A 836
GLY A 839
VAL A 841
 None
None
None
8ST  A2001 ( 4.6A)
 0.28A 5izjB-3hngA:
22.2		 5izjB-3hngA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 7 GLY A 834
GLY A 836
VAL A 841
LYS A 861
 None
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
 0.48A 5izjA-3hngA:
22.2		 5izjA-3hngA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 11 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.42A 5lvnA-3hngA:
23.1		 5lvnA-3hngA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLY A 834
VAL A 841
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
 None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
 0.69A 5mafA-3hngA:
23.0		 5mafA-3hngA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 10 LEU A 833
VAL A 841
LYS A 861
GLU A 878
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
 0.57A 5mo4A-3hngA:
25.9		 5mo4A-3hngA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 10 LEU A 833
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.60A 5n3hA-3hngA:
22.0		 5n3hA-3hngA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 8 ALA A 859
GLU A 878
CYH A 912
LEU A1029
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
 0.56A 5owrA-3hngA:
20.5		 5owrA-3hngA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 5 LEU A 833
VAL A 841
CYH A 912
CYH A1039
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-3.8A)
8ST  A2001 (-4.2A)
 0.42A 5te0A-3hngA:
22.9		 5te0A-3hngA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 859
GLU A 878
TYR A 911
CYH A 912
GLY A 915
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
 0.83A 5vc3A-3hngA:
22.1		 5vc3A-3hngA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 GLY A 834
ALA A 859
TYR A 911
CYH A 912
GLY A 915
ASP A1040
 None
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
 0.82A 5vc3A-3hngA:
22.1		 5vc3A-3hngA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
 0.64A 5vcyA-3hngA:
22.1		 5vcyA-3hngA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 9 LEU A 833
ALA A 859
VAL A 892
CYH A 912
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-3.8A)
None
 0.56A 5w5vA-3hngA:
11.4		 5w5vA-3hngA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.77A 5y7zA-3hngA:
16.2		 5y7zA-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.77A 5y7zA-3hngA:
16.2		 5y7zA-3hngA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
GLU A 878
CYH A 912
GLY A 915
LEU A1029
CYH A1039
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
None
 0.92A 5y7zB-3hngA:
22.2		 5y7zB-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
ALA A 859
LYS A 861
GLU A 878
GLY A 915
LEU A1029
CYH A1039
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 (-4.2A)
None
 0.98A 5y7zB-3hngA:
22.2		 5y7zB-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.66A 5y80A-3hngA:
22.0		 5y80A-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
VAL A 909
TYR A 911
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
 0.23A 5zv2A-3hngA:
33.7		 5zv2A-3hngA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 909
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
 0.31A 5zv2B-3hngA:
33.5		 5zv2B-3hngA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
 0.65A 6bsdA-3hngA:
32.0		 6bsdA-3hngA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.87A 6hd4A-3hngA:
32.7		 6hd4A-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
LYS A 861
GLU A 878
ILE A 885
VAL A 892
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
 0.91A 6hd4A-3hngA:
32.7		 6hd4A-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.88A 6hd4B-3hngA:
32.6		 6hd4B-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 833
VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.89A 6hd6B-3hngA:
32.4		 6hd6B-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
ILE A 885
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
None
 1.01A 6hd6B-3hngA:
32.4		 6hd6B-3hngA:
12.22