SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8S9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FSL_B_NIOB145_1 (LEGHEMOGLOBIN A)	5mwa	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	4 / 8	PHE A 92 ILE A 88 PHE A 86 LEU A 23	8S9 A 302 (-4.5A) None None None	0.73A	1fslB-5mwaA: undetectable	1fslB-5mwaA: 17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	5mwa	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	PHE A 86 LEU A 23 VAL A 19 THR A 50 ALA A 40	None None 8S9 A 302 (-3.8A) 8S9 A 302 ( 4.8A) None	1.29A	4fiaA-5mwaA: undetectable	4fiaA-5mwaA: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_198A602_1 (CHOLESTEROL 24-HYDROXYLASE)	5mwa	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 12	PHE A 86 LEU A 23 VAL A 19 THR A 50 ALA A 40	None None 8S9 A 302 (-3.8A) 8S9 A 302 ( 4.8A) None	1.29A	4fiaA-5mwaA: undetectable	4fiaA-5mwaA: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OG9_A_TESA503_1 (-)	5mwa	BIFUNCTIONAL EPOXIDE HYDROLASE 2 (Homo sapiens)	5 / 9	VAL A 22 LEU A 23 LEU A 60 PRO A 17 ALA A 18	None None 8S9 A 302 (-4.8A) 8S9 A 302 (-4.3A) None	1.22A	5og9A-5mwaA: undetectable	5og9A-5mwaA: 9.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FSL_B_NIOB145_1","LEGHEMOGLOBIN A","5mwa","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",4,"PHE A  92;ILE A  88;PHE A  86;LEU A  23","8S9 A 302 (-4.5A);None;None;None","0.73A","1fslB-5mwaA:undetectable",null],["4FIA_A_0U9A601_1","CHOLESTEROL 24-HYDROXYLASE","5mwa","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"PHE A  86;LEU A  23;VAL A  19;THR A  50;ALA A  40","None;None;8S9 A 302 (-3.8A);8S9 A 302 ( 4.8A);None","1.29A","4fiaA-5mwaA:undetectable","1fslB-5mwaA:17.61"],["4FIA_A_198A602_1","CHOLESTEROL 24-HYDROXYLASE","5mwa","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"PHE A  86;LEU A  23;VAL A  19;THR A  50;ALA A  40","None;None;8S9 A 302 (-3.8A);8S9 A 302 ( 4.8A);None","1.29A","4fiaA-5mwaA:undetectable","4fiaA-5mwaA:10.75"],["5OG9_A_TESA503_1","-","5mwa","BIFUNCTIONAL EPOXIDE HYDROLASE 2","Homo sapiens",5,"VAL A  22;LEU A  23;LEU A  60;PRO A  17;ALA A  18","None;None;8S9 A 302 (-4.8A);8S9 A 302 (-4.3A);None","1.22A","5og9A-5mwaA:undetectable","4fiaA-5mwaA:10.75"]]