SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8R5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.20A 1ya3A-5nagA:
undetectable		 1ya3A-5nagA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.23A 2aa5A-5nagA:
undetectable		 2aa5A-5nagA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.23A 2aa6A-5nagA:
undetectable		 2aa6A-5nagA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.27A 2oaxD-5nagA:
undetectable		 2oaxD-5nagA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A  53
ARG A 111
TYR A 193
ASP A 311
 FAD  A 501 (-3.9A)
FAD  A 501 (-2.8A)
8R5  A 502 (-3.9A)
FAD  A 501 (-2.8A)
 1.11A 2qebA-5nagA:
undetectable		 2qebA-5nagA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 7 ILE A  53
ARG A 111
TYR A 193
ASP A 311
 FAD  A 501 (-3.9A)
FAD  A 501 (-2.8A)
8R5  A 502 (-3.9A)
FAD  A 501 (-2.8A)
 1.14A 2qebB-5nagA:
undetectable		 2qebB-5nagA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 PHE A 319
PHE A 266
ALA A 262
GLY A 192
GLN A 189
 8R5  A 502 (-4.9A)
None
None
None
None
 1.24A 2ve3B-5nagA:
undetectable		 2ve3B-5nagA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		5 / 10 ALA A 366
ASN A 325
ALA A  58
ILE A 106
LEU A 213
 None
FAD  A 501 (-3.9A)
None
None
8R5  A 502 ( 4.6A)
 1.05A 3fl9F-5nagA:
undetectable		 3fl9F-5nagA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5nag KYNURENINE
3-MONOOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 PHE A 238
ILE A 224
GLY A 321
ILE A 106
 8R5  A 502 (-4.2A)
8R5  A 502 (-4.6A)
8R5  A 502 ( 3.3A)
None
 0.70A 4qogA-5nagA:
undetectable
4qogB-5nagA:
undetectable		 4qogA-5nagA:
19.96
4qogB-5nagA:
19.96