SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8Q2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 ILE A 318
ALA A 320
PHE A 212
ILE A 224
ARG A 294
 None
8Q2  A 501 (-3.2A)
None
None
None
 1.20A 1dlsA-5n81A:
undetectable		 1dlsA-5n81A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 THR A 188
TYR A 187
ILE A 117
ILE A 126
ALA A 228
 8Q2  A 501 ( 4.8A)
None
None
None
None
 1.30A 1jtxA-5n81A:
undetectable		 1jtxA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		6 / 12 GLY A 371
ALA A 413
ASP A 411
THR A 330
PRO A 349
ILE A 421
 None
None
8Q2  A 501 (-2.7A)
None
None
None
 1.43A 2nmyA-5n81A:
undetectable		 2nmyA-5n81A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 5 TYR A 317
PRO A 287
THR A 291
THR A 276
 None
None
None
8Q2  A 501 ( 4.9A)
 1.43A 3q07A-5n81A:
undetectable		 3q07A-5n81A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 5 TYR A 317
PRO A 287
THR A 291
THR A 276
 None
None
None
8Q2  A 501 ( 4.9A)
 1.41A 3q07B-5n81A:
undetectable		 3q07B-5n81A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
THR A 324
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-3.7A)
 0.26A 3vnsA-5n81A:
50.2		 3vnsA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 9 ALA A 381
ILE A  89
VAL A 115
GLY A 197
THR A 188
 None
None
None
None
8Q2  A 501 ( 4.8A)
 1.00A 4r20B-5n81A:
undetectable		 4r20B-5n81A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
THR A 324
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-3.7A)
 0.27A 4zxiA-5n81A:
49.6		 4zxiA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		4 / 7 PHE A 232
ASP A 233
GLY A 300
GLY A 322
 8Q2  A 501 (-4.6A)
8Q2  A 501 (-2.7A)
8Q2  A 501 (-3.2A)
8Q2  A 501 (-4.1A)
 0.52A 5n9xA-5n81A:
49.3		 5n9xA-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5n81 TYROCIDINE SYNTHASE
1
(Brevibacillus
parabrevis) 		5 / 12 VAL A 218
LEU A 327
LEU A 208
SER A 245
GLY A 225
 None
8Q2  A 501 (-4.9A)
None
None
None
 1.04A 6b0iB-5n81A:
undetectable		 6b0iB-5n81A:
17.07