SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8PP'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_A_IMNA2_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	1y0g	PROTEIN YCEI (Escherichia coli)	5 / 12	PHE A 96 LEU A 181 LEU A 127 LEU A 172 LEU A 48	8PP A 320 (-4.5A) None None 8PP A 320 (-4.0A) 8PP A 320 (-4.3A)	1.36A	3adsA-1y0gA: undetectable	3adsA-1y0gA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KW4_A_TICA600_1 (CYTOCHROME P450 2B4)	1y0g	PROTEIN YCEI (Escherichia coli)	5 / 11	ILE A 75 ILE A 161 ILE A 183 VAL A 36 GLY A 159	8PP A 320 (-4.2A) 8PP A 320 (-4.8A) 8PP A 320 (-4.3A) 8PP A 320 (-4.7A) None	0.94A	3kw4A-1y0gA: undetectable	3kw4A-1y0gA: 19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_0 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	1y0g	PROTEIN YCEI (Escherichia coli)	5 / 12	SER A 79 THR A 78 ALA A 105 LEU A 125 LEU A 97	None None 8PP A 320 (-3.6A) 8PP A 320 ( 4.4A) None	1.36A	3lcvB-1y0gA: undetectable	3lcvB-1y0gA: 24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1y0g	PROTEIN YCEI (Escherichia coli)	4 / 4	GLY A 50 LEU A 127 PHE A 166 ILE A 161	None None None 8PP A 320 (-4.8A)	0.86A	4xv2A-1y0gA: undetectable	4xv2A-1y0gA: 22.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ADS_A_IMNA2_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","1y0g","PROTEIN YCEI","Escherichia coli",5,"PHE A  96;LEU A 181;LEU A 127;LEU A 172;LEU A  48","8PP A 320 (-4.5A);None;None;8PP A 320 (-4.0A);8PP A 320 (-4.3A)","1.36A","3adsA-1y0gA:undetectable",null],["3KW4_A_TICA600_1","CYTOCHROME P450 2B4","1y0g","PROTEIN YCEI","Escherichia coli",5,"ILE A  75;ILE A 161;ILE A 183;VAL A  36;GLY A 159","8PP A 320 (-4.2A);8PP A 320 (-4.8A);8PP A 320 (-4.3A);8PP A 320 (-4.7A);None","0.94A","3kw4A-1y0gA:undetectable","3adsA-1y0gA:22.03"],["3LCV_B_SAMB301_0","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","1y0g","PROTEIN YCEI","Escherichia coli",5,"SER A  79;THR A  78;ALA A 105;LEU A 125;LEU A  97","None;None;8PP A 320 (-3.6A);8PP A 320 ( 4.4A);None","1.36A","3lcvB-1y0gA:undetectable","3kw4A-1y0gA:19.06"],["4XV2_A_P06A801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1y0g","PROTEIN YCEI","Escherichia coli",4,"GLY A  50;LEU A 127;PHE A 166;ILE A 161","None;None;None;8PP A 320 (-4.8A)","0.86A","4xv2A-1y0gA:undetectable","3lcvB-1y0gA:24.19"]]