SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8NU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 LEU A  94
ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.88A 2y00A-6cm4A:
30.5		 2y00A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 LEU A  94
ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.90A 2y00B-6cm4A:
30.6		 2y00B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 LEU A  94
ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.93A 2y01B-6cm4A:
30.3		 2y01B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.27A 2y03A-6cm4A:
30.5		 2y03A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.61A 2y03A-6cm4A:
30.5		 2y03A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.61A 2y03B-6cm4A:
30.5		 2y03B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
SER A 193
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.99A 2y03B-6cm4A:
30.5		 2y03B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.28A 2y04A-6cm4A:
30.4		 2y04A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 11 ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.81A 2y04A-6cm4A:
30.4		 2y04A-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.27A 2y04B-6cm4A:
30.4		 2y04B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.78A 2y04B-6cm4A:
30.4		 2y04B-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
TRP A 386
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.61A 3d4sA-6cm4A:
35.5		 3d4sA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 THR A 119
SER A 197
PHE A 389
 8NU  A2001 ( 4.4A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
 0.56A 3d4sA-6cm4A:
35.5		 3d4sA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.49A 3nyaA-6cm4A:
35.3		 3nyaA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.84A 3nyaA-6cm4A:
35.3		 3nyaA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 VAL A 196
PHE A 390
PHE A 389
TRP A 386
ILE A 183
 None
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.8A)
None
 1.32A 3owxA-6cm4A:
undetectable
3owxB-6cm4A:
undetectable		 3owxA-6cm4A:
20.31
3owxB-6cm4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
THR A 119
TRP A 386
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.56A 3rzeA-6cm4A:
37.3		 3rzeA-6cm4A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 ASP A 114
VAL A 115
SER A 197
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.71A 4amjA-6cm4A:
30.5		 4amjA-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		7 / 12 LEU A  94
ASP A 114
SER A 197
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 None
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.81A 4amjB-6cm4A:
30.6		 4amjB-6cm4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 ASP A 114
CYH A 118
TRP A 386
PHE A 389
PHE A 390
THR A 412
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 3.8A)
 0.79A 4iaqA-6cm4A:
28.5		 4iaqA-6cm4A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ASP A 114
CYH A 118
TRP A 386
PHE A 389
THR A 412
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.8A)
 0.83A 4iarA-6cm4A:
27.5		 4iarA-6cm4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ASP A 114
VAL A 115
SER A 197
PHE A 389
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.9A)
 0.77A 4ldoA-6cm4A:
26.6		 4ldoA-6cm4A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 VAL A 196
PHE A 390
PHE A 389
TRP A 386
ILE A 183
 None
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.8A)
None
 1.29A 4zvmA-6cm4A:
undetectable
4zvmB-6cm4A:
undetectable		 4zvmA-6cm4A:
20.00
4zvmB-6cm4A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 THR A 119
PHE A 382
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.53A 6a93A-6cm4A:
29.9		 6a93A-6cm4A:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
THR A 119
TRP A 386
PHE A 389
PHE A 390
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.45A 6a93B-6cm4A:
32.1		 6a93B-6cm4A:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 VAL A 190
SER A 197
PHE A 382
TRP A 386
PHE A 389
PHE A 390
 None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.47A 6a94A-6cm4A:
31.6		 6a94A-6cm4A:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		8 / 12 VAL A 115
THR A 119
VAL A 190
SER A 197
PHE A 382
TRP A 386
PHE A 389
PHE A 390
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.55A 6a94B-6cm4A:
31.5		 6a94B-6cm4A:
33.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 SER A 194
PHE A 382
TRP A 386
TYR A 408
THR A 412
 None
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
 0.79A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		12 / 12 TRP A 100
PHE A 110
VAL A 115
CYH A 118
THR A 119
SER A 193
PHE A 382
TRP A 386
PHE A 390
TYR A 408
THR A 412
TYR A 416
 None
8NU  A2001 ( 4.9A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.7A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.0A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.9A)
 0.00A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 ASP A 114
ALA A 122
SER A 197
PHE A 389
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.3A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
 0.01A 6cm4A-6cm4A:
55.7		 6cm4A-6cm4A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
THR A 119
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.4A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.79A 6drzA-6cm4A:
26.8		 6drzA-6cm4A:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 ASP A 114
VAL A 115
SER A 194
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.53A 6h7jA-6cm4A:
26.4		 6h7jA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 194
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 0.70A 6h7jA-6cm4A:
26.4		 6h7jA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
SER A 193
SER A 194
PHE A 389
PHE A 390
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.84A 6h7jA-6cm4A:
26.4		 6h7jA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		6 / 12 ASP A 114
VAL A 115
SER A 194
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.53A 6h7jB-6cm4A:
19.7		 6h7jB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 194
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 0.71A 6h7jB-6cm4A:
19.7		 6h7jB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
SER A 193
SER A 194
PHE A 389
PHE A 390
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.83A 6h7jB-6cm4A:
19.7		 6h7jB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 193
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 1.10A 6h7lA-6cm4A:
26.5		 6h7lA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 193
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 1.09A 6h7lB-6cm4A:
26.7		 6h7lB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.13A 6h7mA-6cm4A:
26.5		 6h7mA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.49A 6h7mA-6cm4A:
26.5		 6h7mA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 197
PHE A 389
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.9A)
 0.75A 6h7mA-6cm4A:
26.5		 6h7mA-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.12A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.48A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ASP A 114
VAL A 115
SER A 197
PHE A 389
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.9A)
 0.73A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.60A 6iblA-6cm4A:
26.6		 6iblA-6cm4A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 VAL A 115
TRP A 386
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.8A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.58A 6iblB-6cm4A:
26.7		 6iblB-6cm4A:
25.85