SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8MM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		7 / 10 PHE A  29
ASP A  32
ASP A  37
GLU A  79
SER A 114
SER A 116
ASP A 176
 8MM  A 201 ( 4.9A)
8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-3.7A)
8MM  A 201 (-4.4A)
 0.62A 1m4dA-5us1A:
27.9		 1m4dA-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		6 / 9 ASP A  32
ASP A  37
GLU A  79
SER A 114
SER A 116
ASP A 176
 8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-3.7A)
8MM  A 201 (-4.4A)
 0.47A 1m4dB-5us1A:
28.3		 1m4dB-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 9 ASP A  32
ASP A  37
GLU A  79
SER A 114
ASP A 176
 8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.4A)
 0.49A 1m4gA-5us1A:
28.0		 1m4gA-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 9 ASP A  37
GLU A  79
SER A 114
SER A 116
ASP A 176
 8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-3.7A)
8MM  A 201 (-4.4A)
 0.73A 1m4gA-5us1A:
28.0		 1m4gA-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		6 / 9 ASP A  32
ASP A  37
GLU A  79
SER A 114
SER A 116
ASP A 176
 8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-3.7A)
8MM  A 201 (-4.4A)
 0.79A 1m4gB-5us1A:
28.2		 1m4gB-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 8 ASP A  32
ASP A  37
GLU A  79
SER A 114
ASP A 176
 8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.4A)
 0.51A 1m4iA-5us1A:
27.9		 1m4iA-5us1A:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M4I_B_KANB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		6 / 9 ASP A  32
ASP A  37
GLU A  79
SER A 114
SER A 116
ASP A 176
 8MM  A 201 ( 4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-4.5A)
8MM  A 201 (-3.3A)
8MM  A 201 (-3.7A)
8MM  A 201 (-4.4A)
 0.67A 1m4iB-5us1A:
28.1		 1m4iB-5us1A:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 9 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.41A 1pw7B-5us1A:
undetectable		 1pw7B-5us1A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 11 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.42A 1vhwA-5us1A:
undetectable
1vhwD-5us1A:
undetectable		 1vhwA-5us1A:
19.18
1vhwD-5us1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 11 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.44A 1vhwC-5us1A:
undetectable
1vhwE-5us1A:
undetectable		 1vhwC-5us1A:
19.18
1vhwE-5us1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 11 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.44A 1vhwA-5us1A:
undetectable
1vhwD-5us1A:
undetectable		 1vhwA-5us1A:
19.18
1vhwD-5us1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 11 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.42A 1vhwC-5us1A:
undetectable
1vhwE-5us1A:
undetectable		 1vhwC-5us1A:
19.18
1vhwE-5us1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		4 / 5 SER A 116
GLU A  79
TYR A  77
SER A  34
 8MM  A 201 (-3.7A)
8MM  A 201 (-4.5A)
None
None
 1.47A 1vidA-5us1A:
undetectable		 1vidA-5us1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		4 / 7 GLY A 155
ILE A 104
THR A 100
LEU A 113
 None
None
None
8MM  A 201 ( 4.9A)
 0.93A 2xrhA-5us1A:
undetectable		 2xrhA-5us1A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		5 / 10 ARG A 173
GLY A  76
VAL A  78
GLU A  79
ILE A 104
 None
None
None
8MM  A 201 (-4.5A)
None
 1.36A 3uayA-5us1A:
undetectable		 3uayA-5us1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE
(Providencia
stuartii) 		4 / 5 SER A 116
GLU A  79
TYR A  77
SER A  34
 8MM  A 201 (-3.7A)
8MM  A 201 (-4.5A)
None
None
 1.43A 5fhrA-5us1A:
undetectable		 5fhrA-5us1A:
21.19