SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8LM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1V3E_A_ZMRA1200_1 (HEMAGGLUTININ-NEURAM INIDASE GLYCOPROTEIN)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	9 / 10	ARG A 192 THR A 193 GLU A 276 TYR A 319 TYR A 337 PHE A 372 GLU A 409 ARG A 424 ARG A 502	8LM A 610 (-3.3A) 8LM A 610 ( 4.6A) 8LM A 610 (-2.8A) 8LM A 610 (-3.3A) 8LM A 610 (-4.5A) None 8LM A 610 (-3.9A) 8LM A 610 (-3.7A) 8LM A 610 (-2.9A)	0.58A	1v3eA-6c0mA: 68.9	1v3eA-6c0mA: 98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1V3E_B_ZMRB2200_1 (HEMAGGLUTININ-NEURAM INIDASE GLYCOPROTEIN)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	9 / 10	ARG A 192 THR A 193 GLU A 276 TYR A 319 TYR A 337 PHE A 372 GLU A 409 ARG A 424 ARG A 502	8LM A 610 (-3.3A) 8LM A 610 ( 4.6A) 8LM A 610 (-2.8A) 8LM A 610 (-3.3A) 8LM A 610 (-4.5A) None 8LM A 610 (-3.9A) 8LM A 610 (-3.7A) 8LM A 610 (-2.9A)	0.68A	1v3eB-6c0mA: 68.7	1v3eB-6c0mA: 98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F0Z_A_ZMRA381_1 (SIALIDASE 2)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	5 / 12	ARG A 192 GLU A 276 TYR A 337 GLU A 409 ARG A 424	8LM A 610 (-3.3A) 8LM A 610 (-2.8A) 8LM A 610 (-4.5A) 8LM A 610 (-3.9A) 8LM A 610 (-3.7A)	1.08A	2f0zA-6c0mA: 27.5	2f0zA-6c0mA: 10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F0Z_A_ZMRA381_1 (SIALIDASE 2)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	5 / 12	GLU A 276 TYR A 337 GLU A 409 ARG A 424 ARG A 502	8LM A 610 (-2.8A) 8LM A 610 (-4.5A) 8LM A 610 (-3.9A) 8LM A 610 (-3.7A) 8LM A 610 (-2.9A)	0.57A	2f0zA-6c0mA: 27.5	2f0zA-6c0mA: 10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	3 / 3	GLY A 227 ARG A 242 TYR A 203	None 8LM A 611 (-3.7A) None	0.87A	2opxA-6c0mA: undetectable	2opxA-6c0mA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP2_A_PNNA5001_0 (TRANSCRIPTIONAL REGULATOR TCAR)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	4 / 8	ASN A 208 THR A 193 SER A 257 ASN A 252	None 8LM A 610 ( 4.6A) None None	1.07A	3kp2A-6c0mA: undetectable 3kp2B-6c0mA: undetectable	3kp2A-6c0mA: undetectable 3kp2B-6c0mA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KHP_A_PARA1606_1 (16S RIBOSOMAL RNA 30S RIBOSOMAL PROTEIN S9 30S RIBOSOMAL PROTEIN S10)	6c0m	HEMAGGLUTININ-NEURAM INIDASE (Human respirovirus 3)	3 / 3	TYR A 337 ARG A 424 SER A 408	8LM A 610 (-4.5A) 8LM A 610 (-3.7A) None	0.94A	4khpI-6c0mA: undetectable 4khpJ-6c0mA: undetectable	4khpI-6c0mA: 18.55 4khpJ-6c0mA: 23.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1V3E_A_ZMRA1200_1","HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",9,"ARG A 192;THR A 193;GLU A 276;TYR A 319;TYR A 337;PHE A 372;GLU A 409;ARG A 424;ARG A 502","8LM A 610 (-3.3A);8LM A 610 ( 4.6A);8LM A 610 (-2.8A);8LM A 610 (-3.3A);8LM A 610 (-4.5A);None;8LM A 610 (-3.9A);8LM A 610 (-3.7A);8LM A 610 (-2.9A)","0.58A","1v3eA-6c0mA:68.9",null],["1V3E_B_ZMRB2200_1","HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",9,"ARG A 192;THR A 193;GLU A 276;TYR A 319;TYR A 337;PHE A 372;GLU A 409;ARG A 424;ARG A 502","8LM A 610 (-3.3A);8LM A 610 ( 4.6A);8LM A 610 (-2.8A);8LM A 610 (-3.3A);8LM A 610 (-4.5A);None;8LM A 610 (-3.9A);8LM A 610 (-3.7A);8LM A 610 (-2.9A)","0.68A","1v3eB-6c0mA:68.7","1v3eA-6c0mA:98.75"],["2F0Z_A_ZMRA381_1","SIALIDASE 2","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",5,"ARG A 192;GLU A 276;TYR A 337;GLU A 409;ARG A 424","8LM A 610 (-3.3A);8LM A 610 (-2.8A);8LM A 610 (-4.5A);8LM A 610 (-3.9A);8LM A 610 (-3.7A)","1.08A","2f0zA-6c0mA:27.5","1v3eB-6c0mA:98.75"],["2F0Z_A_ZMRA381_1","SIALIDASE 2","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",5,"GLU A 276;TYR A 337;GLU A 409;ARG A 424;ARG A 502","8LM A 610 (-2.8A);8LM A 610 (-4.5A);8LM A 610 (-3.9A);8LM A 610 (-3.7A);8LM A 610 (-2.9A)","0.57A","2f0zA-6c0mA:27.5","2f0zA-6c0mA:10.06"],["2OPX_A_DXCA1002_0","ALDEHYDE DEHYDROGENASE A","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",3,"GLY A 227;ARG A 242;TYR A 203","None;8LM A 611 (-3.7A);None","0.87A","2opxA-6c0mA:undetectable","2f0zA-6c0mA:10.06"],["3KP2_A_PNNA5001_0","TRANSCRIPTIONAL REGULATOR TCAR","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",4,"ASN A 208;THR A 193;SER A 257;ASN A 252","None;8LM A 610 ( 4.6A);None;None","1.07A","3kp2A-6c0mA:undetectable;3kp2B-6c0mA:undetectable","2opxA-6c0mA:undetectable"],["4KHP_A_PARA1606_1","16S RIBOSOMAL RNA;30S RIBOSOMAL PROTEIN S9;30S RIBOSOMAL PROTEIN S10","6c0m","HEMAGGLUTININ-NEURAMINIDASE","Human respirovirus 3",3,"TYR A 337;ARG A 424;SER A 408","8LM A 610 (-4.5A);8LM A 610 (-3.7A);None","0.94A","4khpI-6c0mA:undetectable;4khpJ-6c0mA:undetectable","3kp2A-6c0mA:undetectable;3kp2B-6c0mA:undetectable"]]