SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8L1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 11 ASN A 275
GLY A 298
CYH A 303
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.38A 1jr1A-5uzeA:
52.0		 1jr1A-5uzeA:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 8 ASN A 275
GLY A 298
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.27A 1jr1B-5uzeA:
51.7		 1jr1B-5uzeA:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASP A 246
ASN A 275
CYH A 303
THR A 305
MET A 386
GLY A 387
 None
IMP  A 500 (-4.0A)
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.38A 4fo4A-5uzeA:
55.5		 4fo4A-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASN A 275
GLY A 298
CYH A 303
THR A 305
MET A 386
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.27A 4fo4B-5uzeA:
55.0		 4fo4B-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
ASP A 336
 IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 (-2.4A)
 0.32A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASP A 246
ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
 None
IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
 0.77A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 VAL A 232
GLY A 258
TYR A 266
ILE A 256
SER A 252
 None
None
None
None
8L1  A 501 (-3.6A)
 1.29A 4xudA-5uzeA:
undetectable		 4xudA-5uzeA:
21.25