SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8K8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A1348
ALA A1196
SER A1240
ALA A1159
ASP A1160
 None
8K8  A2001 ( 3.5A)
None
None
None
 1.46A 2qm9A-5n2sA:
undetectable		 2qm9A-5n2sA:
16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		7 / 12 LEU A1193
PHE A1276
MET A1285
TRP A1352
LEU A1355
ASN A1359
HIS A1383
 None
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
None
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
None
 0.72A 2ydoA-5n2sA:
29.6		 2ydoA-5n2sA:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		7 / 12 LEU A1193
PHE A1276
TRP A1352
LEU A1355
ASN A1359
ILE A1379
HIS A1383
 None
8K8  A2001 ( 3.4A)
None
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
None
 0.89A 2ydoA-5n2sA:
29.6		 2ydoA-5n2sA:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 7 VAL A1192
PHE A1276
LEU A1355
ASN A1359
ILE A1379
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
 0.87A 3rfmA-5n2sA:
34.0		 3rfmA-5n2sA:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 7 VAL A1192
PHE A1276
MET A1285
LEU A1355
ASN A1359
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
 0.89A 3rfmA-5n2sA:
34.0		 3rfmA-5n2sA:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		4 / 8 LEU A1193
PHE A1276
MET A1285
ASN A1359
 None
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 3.1A)
 0.49A 5mzjA-5n2sA:
34.7		 5mzjA-5n2sA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 8 PHE A1276
MET A1285
LEU A1355
ASN A1359
ILE A1379
 8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
 0.57A 5mzjA-5n2sA:
34.7		 5mzjA-5n2sA:
37.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		7 / 9 ILE A1174
VAL A1192
PHE A1276
MET A1285
LEU A1355
ASN A1359
ILE A1379
 8K8  A2001 ( 4.0A)
8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
 0.73A 5mzpA-5n2sA:
34.8		 5mzpA-5n2sA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP A1352
LEU A1355
HIS A1356
ILE A1379
ALA A1382
 None
8K8  A2001 ( 4.3A)
8K8  A2001 ( 4.1A)
8K8  A2001 ( 4.2A)
None
 0.54A 5xprA-5n2sA:
24.5		 5xprA-5n2sA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 VAL A1192
LEU A1355
ASN A1359
ILE A1379
HIS A1383
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
8K8  A2001 ( 4.2A)
None
 1.08A 6d9hR-5n2sA:
32.3		 6d9hR-5n2sA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 VAL A1192
MET A1285
LEU A1355
ASN A1359
HIS A1383
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 3.1A)
None
 1.00A 6d9hR-5n2sA:
32.3		 6d9hR-5n2sA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 VAL A1192
PHE A1276
LEU A1355
ILE A1379
HIS A1383
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.3A)
8K8  A2001 ( 4.2A)
None
 1.07A 6d9hR-5n2sA:
32.3		 6d9hR-5n2sA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens) 		5 / 10 VAL A1192
PHE A1276
MET A1285
LEU A1355
HIS A1383
 8K8  A2001 ( 4.1A)
8K8  A2001 ( 3.4A)
8K8  A2001 ( 4.5A)
8K8  A2001 ( 4.3A)
None
 1.13A 6d9hR-5n2sA:
32.3		 6d9hR-5n2sA:
30.30