SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8JB'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	5n29	CTP SYNTHASE (Trypanosoma brucei)	5 / 10	VAL A 493 PHE A 388 VAL A 344 VAL A 418 VAL A 546	None None None 8JB A 419 ( 3.0A) None	1.27A	1fe2A-5n29A: undetectable	1fe2A-5n29A: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NHX_A_ASDA126_1 (STEROID DELTA-ISOMERASE)	5n29	CTP SYNTHASE (Trypanosoma brucei)	5 / 12	TYR A 487 SER A 565 PHE A 548 VAL A 418 ALA A 534	None None None 8JB A 419 ( 3.0A) None	1.46A	3nhxA-5n29A: undetectable	3nhxA-5n29A: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_B_MTXB301_1 (GAMMA-GLUTAMYL HYDROLASE)	5n29	CTP SYNTHASE (Trypanosoma brucei)	5 / 11	GLY A 391 GLY A 392 LEU A 420 HIS A 499 HIS A 549	8JB A 419 ( 3.4A) 8JB A 419 ( 4.1A) 8JB A 419 ( 4.6A) None 8JB A 419 ( 4.0A)	0.64A	4l8fB-5n29A: 18.1	4l8fB-5n29A: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_D_MTXD301_1 (GAMMA-GLUTAMYL HYDROLASE)	5n29	CTP SYNTHASE (Trypanosoma brucei)	5 / 11	GLY A 391 GLY A 392 LEU A 420 HIS A 499 HIS A 549	8JB A 419 ( 3.4A) 8JB A 419 ( 4.1A) 8JB A 419 ( 4.6A) None 8JB A 419 ( 4.0A)	0.64A	4l8fD-5n29A: 18.2	4l8fD-5n29A: 22.43

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FE2_A_LAXA700_1","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","5n29","CTP SYNTHASE","Trypanosoma brucei",5,"VAL A 493;PHE A 388;VAL A 344;VAL A 418;VAL A 546","None;None;None;8JB A 419 ( 3.0A);None","1.27A","1fe2A-5n29A:undetectable",null],["3NHX_A_ASDA126_1","STEROID DELTA-ISOMERASE","5n29","CTP SYNTHASE","Trypanosoma brucei",5,"TYR A 487;SER A 565;PHE A 548;VAL A 418;ALA A 534","None;None;None;8JB A 419 ( 3.0A);None","1.46A","3nhxA-5n29A:undetectable","1fe2A-5n29A:17.50"],["4L8F_B_MTXB301_1","GAMMA-GLUTAMYL HYDROLASE","5n29","CTP SYNTHASE","Trypanosoma brucei",5,"GLY A 391;GLY A 392;LEU A 420;HIS A 499;HIS A 549","8JB A 419 ( 3.4A);8JB A 419 ( 4.1A);8JB A 419 ( 4.6A);None;8JB A 419 ( 4.0A)","0.64A","4l8fB-5n29A:18.1","3nhxA-5n29A:18.38"],["4L8F_D_MTXD301_1","GAMMA-GLUTAMYL HYDROLASE","5n29","CTP SYNTHASE","Trypanosoma brucei",5,"GLY A 391;GLY A 392;LEU A 420;HIS A 499;HIS A 549","8JB A 419 ( 3.4A);8JB A 419 ( 4.1A);8JB A 419 ( 4.6A);None;8JB A 419 ( 4.0A)","0.64A","4l8fD-5n29A:18.2","4l8fB-5n29A:22.43"]]