SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8IG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		6 / 10 GLY A 137
GLU A 204
VAL A 220
GLY A 221
MET A 222
THR A 245
 8IG  A 306 (-3.3A)
8IG  A 306 (-2.8A)
8IG  A 306 (-4.6A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
8IG  A 306 (-3.0A)
 0.61A 1pwyE-1c3xA:
30.6		 1pwyE-1c3xA:
35.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		6 / 10 GLY A 137
GLU A 204
VAL A 220
GLY A 221
MET A 222
THR A 245
 8IG  A 306 (-3.3A)
8IG  A 306 (-2.8A)
8IG  A 306 (-4.6A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
8IG  A 306 (-3.0A)
 0.49A 1v3qE-1c3xA:
30.5		 1v3qE-1c3xA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		5 / 10 LEU A 247
ALA A 249
ILE A 251
VAL A 220
ALA A 196
 None
None
None
8IG  A 306 (-4.6A)
None
 1.18A 1xp0A-1c3xA:
undetectable		 1xp0A-1c3xA:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		5 / 6 GLY A 137
TYR A 203
GLU A 204
GLY A 221
MET A 222
 8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.46A 3e9rA-1c3xA:
30.5		 3e9rA-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		4 / 6 GLY A 221
TYR A 203
GLU A 204
GLY A 200
 8IG  A 306 (-3.4A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
None
 1.07A 3e9rA-1c3xA:
30.5		 3e9rA-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		5 / 6 GLY A 137
TYR A 203
GLU A 204
GLY A 221
MET A 222
 8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.48A 3e9rC-1c3xA:
30.6		 3e9rC-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		4 / 6 GLY A 221
TYR A 203
GLU A 204
GLY A 200
 8IG  A 306 (-3.4A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
None
 1.08A 3e9rC-1c3xA:
30.6		 3e9rC-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		8 / 12 SER A  46
TYR A 107
GLY A 137
TYR A 203
GLU A 204
VAL A 220
GLY A 221
MET A 222
 PO4  A 303 (-3.9A)
None
8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-4.6A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.71A 3f8wA-1c3xA:
30.8		 3f8wA-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		9 / 12 SER A  46
HIS A 105
TYR A 107
GLY A 137
TYR A 203
GLU A 204
VAL A 220
GLY A 221
MET A 222
 PO4  A 303 (-3.9A)
PO4  A 303 (-4.2A)
None
8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-4.6A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.71A 3f8wB-1c3xA:
30.7		 3f8wB-1c3xA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1c3x PENTOSYLTRANSFERASE
(Cellulomonas
sp.) 		9 / 12 SER A  46
HIS A 105
TYR A 107
GLY A 137
TYR A 203
GLU A 204
VAL A 220
GLY A 221
MET A 222
 PO4  A 303 (-3.9A)
PO4  A 303 (-4.2A)
None
8IG  A 306 (-3.3A)
8IG  A 306 (-4.4A)
8IG  A 306 (-2.8A)
8IG  A 306 (-4.6A)
8IG  A 306 (-3.4A)
8IG  A 306 (-4.0A)
 0.70A 3f8wC-1c3xA:
30.9		 3f8wC-1c3xA:
33.68