SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8H6'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)
5xww AMPHB
(Streptomyces
nodosus)
3 / 3 TRP A 359
ALA A 368
VAL A 358
8H6  A 502 (-4.1A)
None
None
0.96A 3l8lA-5xwwA:
undetectable
3l8lB-5xwwA:
undetectable
3l8lA-5xwwA:
undetectable
3l8lB-5xwwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)
5xww AMPHB
(Streptomyces
nodosus)
5 / 12 ALA A 309
LEU A 326
MET A 327
ARG A 251
ALA A 357
8H6  A 502 ( 4.5A)
None
None
NAP  A 501 (-3.6A)
None
1.44A 3lbdA-5xwwA:
undetectable
3lbdA-5xwwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)
5xww AMPHB
(Streptomyces
nodosus)
4 / 5 SER A 354
ILE A 230
TYR A 367
GLY A 394
8H6  A 502 ( 3.2A)
NAP  A 501 (-3.9A)
NAP  A 501 ( 4.5A)
NAP  A 501 (-4.9A)
0.92A 3uboB-5xwwA:
4.8
3uboB-5xwwA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)
5xww AMPHB
(Streptomyces
nodosus)
5 / 12 ALA A 316
GLU A 153
GLY A 362
GLY A 147
LEU A 104
None
None
8H6  A 502 (-3.1A)
None
None
1.05A 4uilH-5xwwA:
undetectable
4uilL-5xwwA:
undetectable
4uilH-5xwwA:
undetectable
4uilL-5xwwA:
undetectable