SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8F5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KI7_B_ID2B2_0 (THYMIDINE KINASE)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 12	GLU A 209 ILE A 20 ILE A 41 ALA A 199 ARG A 21	None None None 8F5 A 301 (-4.0A) None	1.25A	1ki7B-5n0gA: undetectable	1ki7B-5n0gA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_A_REAA502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 12	ALA A 44 ALA A 43 ASN A 202 LEU A 49 ILE A 160	None 8F5 A 301 ( 4.1A) 8F5 A 301 (-3.8A) None None	0.98A	2aclA-5n0gA: undetectable 2aclE-5n0gA: undetectable	2aclA-5n0gA: 18.03 2aclE-5n0gA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_C_REAC503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 10	ILE A 196 ALA A 44 ALA A 43 ASN A 202 ILE A 160	None None 8F5 A 301 ( 4.1A) 8F5 A 301 (-3.8A) None	1.07A	2aclC-5n0gA: undetectable	2aclC-5n0gA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_E_REAE504_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 11	ILE A 196 ALA A 44 ALA A 43 ASN A 202 ILE A 160	None None 8F5 A 301 ( 4.1A) 8F5 A 301 (-3.8A) None	1.11A	2aclE-5n0gA: undetectable	2aclE-5n0gA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FAL_C_REAC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 10	ILE A 196 ALA A 44 ALA A 43 LEU A 49 ILE A 160	None None 8F5 A 301 ( 4.1A) None None	0.87A	3falC-5n0gA: undetectable	3falC-5n0gA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Y_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 12	ILE A 196 ALA A 44 ALA A 43 LEU A 49 ILE A 160	None None 8F5 A 301 ( 4.1A) None None	0.80A	6a5yD-5n0gA: undetectable	6a5yD-5n0gA: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_L_9CRL501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5n0g	PRECORRIN-8X METHYLMUTASE (Rhodobacter capsulatus)	5 / 12	ILE A 196 ALA A 44 ALA A 43 LEU A 49 ILE A 160	None None 8F5 A 301 ( 4.1A) None None	0.90A	6a5zL-5n0gA: undetectable	6a5zL-5n0gA: 22.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KI7_B_ID2B2_0","THYMIDINE KINASE","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"GLU A 209;ILE A  20;ILE A  41;ALA A 199;ARG A  21","None;None;None;8F5 A 301 (-4.0A);None","1.25A","1ki7B-5n0gA:undetectable",null],["2ACL_A_REAA502_1","RETINOIC ACID RECEPTOR RXR-ALPHA;RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ALA A  44;ALA A  43;ASN A 202;LEU A  49;ILE A 160","None;8F5 A 301 ( 4.1A);8F5 A 301 (-3.8A);None;None","0.98A","2aclA-5n0gA:undetectable;2aclE-5n0gA:undetectable","1ki7B-5n0gA:undetectable"],["2ACL_C_REAC503_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ILE A 196;ALA A  44;ALA A  43;ASN A 202;ILE A 160","None;None;8F5 A 301 ( 4.1A);8F5 A 301 (-3.8A);None","1.07A","2aclC-5n0gA:undetectable","2aclA-5n0gA:18.03;2aclE-5n0gA:18.03"],["2ACL_E_REAE504_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ILE A 196;ALA A  44;ALA A  43;ASN A 202;ILE A 160","None;None;8F5 A 301 ( 4.1A);8F5 A 301 (-3.8A);None","1.11A","2aclE-5n0gA:undetectable","2aclC-5n0gA:18.03"],["3FAL_C_REAC501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ILE A 196;ALA A  44;ALA A  43;LEU A  49;ILE A 160","None;None;8F5 A 301 ( 4.1A);None;None","0.87A","3falC-5n0gA:undetectable","2aclE-5n0gA:18.03"],["6A5Y_D_9CRD501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ILE A 196;ALA A  44;ALA A  43;LEU A  49;ILE A 160","None;None;8F5 A 301 ( 4.1A);None;None","0.80A","6a5yD-5n0gA:undetectable","3falC-5n0gA:18.03"],["6A5Z_L_9CRL501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","5n0g","PRECORRIN-8X METHYLMUTASE","Rhodobacter capsulatus",5,"ILE A 196;ALA A  44;ALA A  43;LEU A  49;ILE A 160","None;None;8F5 A 301 ( 4.1A);None;None","0.90A","6a5zL-5n0gA:undetectable","6a5yD-5n0gA:22.08"]]