SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8DG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 LEU A  11
GLY A  36
GLY A  34
ALA A  49
PHE A  86
 None
8DG  A 204 (-3.4A)
None
None
None
 1.21A 3dh0A-5mzeA:
undetectable		 3dh0A-5mzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		5 / 11 PHE A  72
PHE A 137
ILE A  85
GLY A  68
LEU A 150
 8DG  A 204 (-3.7A)
None
None
None
None
 1.03A 3t3rA-5mzeA:
undetectable		 3t3rA-5mzeA:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 LEU A   9
ASN A  33
VAL A  83
TRP A 117
PHE A  74
 8DG  A 204 (-4.2A)
8DG  A 204 (-2.9A)
8DG  A 204 ( 4.9A)
8DG  A 204 (-3.9A)
None
 1.34A 4c9wA-5mzeA:
28.6		 4c9wA-5mzeA:
52.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		11 / 12 TYR A   7
LEU A   9
ASN A  33
PHE A  72
MET A  81
VAL A  83
TRP A 117
ASP A 119
ASP A 120
PHE A 139
GLN A 142
 8DG  A 204 (-4.6A)
8DG  A 204 (-4.2A)
8DG  A 204 (-2.9A)
8DG  A 204 (-3.7A)
8DG  A 204 (-3.5A)
8DG  A 204 ( 4.9A)
8DG  A 204 (-3.9A)
8DG  A 204 (-2.6A)
8DG  A 204 (-2.7A)
None
None
 0.47A 4c9wA-5mzeA:
28.6		 4c9wA-5mzeA:
52.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		11 / 12 TYR A   7
LEU A   9
ASN A  33
PHE A  72
PHE A  74
MET A  81
VAL A  83
TRP A 117
ASP A 119
ASP A 120
PHE A 139
 8DG  A 204 (-4.6A)
8DG  A 204 (-4.2A)
8DG  A 204 (-2.9A)
8DG  A 204 (-3.7A)
None
8DG  A 204 (-3.5A)
8DG  A 204 ( 4.9A)
8DG  A 204 (-3.9A)
8DG  A 204 (-2.6A)
8DG  A 204 (-2.7A)
None
 0.57A 4c9wA-5mzeA:
28.6		 4c9wA-5mzeA:
52.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE
(Mus
musculus) 		5 / 12 TYR A   7
LEU A   9
TRP A 117
ASP A 119
GLN A 142
 8DG  A 204 (-4.6A)
8DG  A 204 (-4.2A)
8DG  A 204 (-3.9A)
8DG  A 204 (-2.6A)
None
 1.47A 4c9wA-5mzeA:
28.6		 4c9wA-5mzeA:
52.29