SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '8AO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoA-5xmrA:
53.7		 1dfoA-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoB-5xmrA:
56.4		 1dfoB-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoC-5xmrA:
56.3		 1dfoC-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.66A 1dfoD-5xmrA:
53.8		 1dfoD-5xmrA:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbA-5xmrA:
53.6		 1eqbA-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbB-5xmrA:
56.1		 1eqbB-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbC-5xmrA:
56.1		 1eqbC-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.65A 1eqbD-5xmrA:
56.8		 1eqbD-5xmrA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		7 / 12 LEU A 124
GLY A 127
HIS A 129
LEU A 130
VAL A 141
ASN A 356
ARG A 371
 8AO  A 502 (-4.3A)
8AO  A 502 ( 4.1A)
PLG  A 501 ( 3.5A)
8AO  A 502 (-4.3A)
8AO  A 502 (-4.0A)
8AO  A 502 (-3.2A)
PLG  A 501 (-3.1A)
 0.73A 2vmyB-5xmrA:
57.3		 2vmyB-5xmrA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		5 / 10 GLY A 369
ASN A 354
ALA A 397
ILE A 337
LEU A 332
 None
8AO  A 502 ( 4.4A)
None
None
None
 1.23A 4xj7A-5xmrA:
undetectable
4xj7B-5xmrA:
undetectable		 4xj7A-5xmrA:
21.49
4xj7B-5xmrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5xmr SERINE
HYDROXYMETHYLTRANSFE
RASE
(Plasmodium
vivax) 		4 / 7 ASN A 356
SER A 184
GLY A 159
VAL A 319
 8AO  A 502 (-3.2A)
8AO  A 502 (-3.3A)
None
None
 0.92A 5fpdA-5xmrA:
undetectable		 5fpdA-5xmrA:
23.18