SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '88L'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W1B_A_DXCA2034_0 (ACRIFLAVIN RESISTANCE PROTEIN B)	5xjn	CYTOCHROME P450 (Corynebacterium glutamicum)	3 / 3	PHE A 127 SER A 261 LEU A 259	HEM A 502 (-3.7A) 88L A 501 ( 2.7A) None	0.63A	2w1bA-5xjnA: 2.7	2w1bA-5xjnA: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E4E_A_4PZA501_1 (CYTOCHROME P450 2E1)	5xjn	CYTOCHROME P450 (Corynebacterium glutamicum)	3 / 3	ALA A 265 THR A 269 CYH A 376	88L A 501 ( 3.1A) HEM A 502 (-3.5A) HEM A 502 (-2.4A)	0.47A	3e4eA-5xjnA: 31.9	3e4eA-5xjnA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E4E_B_4PZB501_1 (CYTOCHROME P450 2E1)	5xjn	CYTOCHROME P450 (Corynebacterium glutamicum)	3 / 3	ALA A 265 THR A 269 CYH A 376	88L A 501 ( 3.1A) HEM A 502 (-3.5A) HEM A 502 (-2.4A)	0.31A	3e4eB-5xjnA: 31.8	3e4eB-5xjnA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_A_CCSA14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2)	5xjn	CYTOCHROME P450 (Corynebacterium glutamicum)	4 / 6	PHE A 416 LEU A 414 ARG A 411 GLY A 200	88L A 501 ( 4.7A) None None None	1.12A	5o4yA-5xjnA: undetectable	5o4yA-5xjnA: 4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_H_RITH602_1 (CYTOCHROME P450 3A5)	5xjn	CYTOCHROME P450 (Corynebacterium glutamicum)	5 / 12	SER A 109 GLY A 200 PHE A 264 ALA A 265 THR A 269	88L A 501 ( 2.4A) None 88L A 501 (-4.2A) 88L A 501 ( 3.1A) HEM A 502 (-3.5A)	0.65A	5veuH-5xjnA: 30.1	5veuH-5xjnA: 24.06

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W1B_A_DXCA2034_0","ACRIFLAVIN RESISTANCE PROTEIN B","5xjn","CYTOCHROME P450","Corynebacterium glutamicum",3,"PHE A 127;SER A 261;LEU A 259","HEM A 502 (-3.7A);88L A 501 ( 2.7A);None","0.63A","2w1bA-5xjnA:2.7",null],["3E4E_A_4PZA501_1","CYTOCHROME P450 2E1","5xjn","CYTOCHROME P450","Corynebacterium glutamicum",3,"ALA A 265;THR A 269;CYH A 376","88L A 501 ( 3.1A);HEM A 502 (-3.5A);HEM A 502 (-2.4A)","0.47A","3e4eA-5xjnA:31.9","2w1bA-5xjnA:18.38"],["3E4E_B_4PZB501_1","CYTOCHROME P450 2E1","5xjn","CYTOCHROME P450","Corynebacterium glutamicum",3,"ALA A 265;THR A 269;CYH A 376","88L A 501 ( 3.1A);HEM A 502 (-3.5A);HEM A 502 (-2.4A)","0.31A","3e4eB-5xjnA:31.8","3e4eA-5xjnA:22.27"],["5O4Y_A_CCSA14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2","5xjn","CYTOCHROME P450","Corynebacterium glutamicum",4,"PHE A 416;LEU A 414;ARG A 411;GLY A 200","88L A 501 ( 4.7A);None;None;None","1.12A","5o4yA-5xjnA:undetectable","3e4eB-5xjnA:22.27"],["5VEU_H_RITH602_1","CYTOCHROME P450 3A5","5xjn","CYTOCHROME P450","Corynebacterium glutamicum",5,"SER A 109;GLY A 200;PHE A 264;ALA A 265;THR A 269","88L A 501 ( 2.4A);None;88L A 501 (-4.2A);88L A 501 ( 3.1A);HEM A 502 (-3.5A)","0.65A","5veuH-5xjnA:30.1","5o4yA-5xjnA:4.85"]]