SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '86X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 0.99A 1jhoA-5xiiA:
undetectable		 1jhoA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.01A 1jhrA-5xiiA:
undetectable		 1jhrA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.01A 1jhyA-5xiiA:
undetectable		 1jhyA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.02A 1l4nA-5xiiA:
undetectable		 1l4nA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.00A 1l5kA-5xiiA:
undetectable		 1l5kA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.00A 1l5lA-5xiiA:
undetectable		 1l5lA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.00A 1l5mA-5xiiA:
undetectable		 1l5mA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 GLU A 472
GLU A 489
HIS A 491
THR A 558
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.96A 4hvcA-5xiiA:
51.5		 4hvcA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		11 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.33A 4hvcA-5xiiA:
51.5		 4hvcA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
ARG A 470
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.7A)
 0.16A 4hvcA-5xiiA:
51.5		 4hvcA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 GLU A 472
GLU A 489
HIS A 491
THR A 558
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.01A 4hvcB-5xiiA:
51.8		 4hvcB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.33A 4hvcB-5xiiA:
51.8		 4hvcB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 5 THR A 439
GLU A 441
ARG A 470
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.7A)
 0.17A 4hvcB-5xiiA:
51.8		 4hvcB-5xiiA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 8 ARG A 470
PHE A 485
GLN A 555
THR A 558
THR A 592
ARG A 594
 ANP  A1001 ( 2.9A)
ANP  A1001 (-3.4A)
ANP  A1001 (-3.6A)
86X  A1004 (-3.9A)
ANP  A1001 (-2.7A)
ANP  A1001 (-3.7A)
 0.55A 4k87A-5xiiA:
50.1		 4k87A-5xiiA:
58.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		8 / 12 GLU A 472
THR A 439
GLU A 441
ARG A 470
GLU A 489
PHE A 534
HIS A 560
SER A 588
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.7A)
86X  A1004 (-3.6A)
 1.45A 4k88A-5xiiA:
49.9		 4k88A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
GLU A 441
ARG A 470
TRP A 487
GLU A 489
PHE A 534
HIS A 560
SER A 588
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.7A)
86X  A1004 (-3.6A)
 0.63A 4k88A-5xiiA:
49.9		 4k88A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 9 THR A 439
GLY A 490
SER A 588
GLU A 441
GLY A 590
 86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.2A)
 1.05A 4kqiA-5xiiA:
undetectable		 4kqiA-5xiiA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
TRP A 487
GLU A 489
HIS A 491
THR A 558
SER A 588
TRP A 589
 ANP  A1001 (-3.4A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
None
 1.17A 4olfA-5xiiA:
52.6		 4olfA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
TRP A 589
GLY A 590
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
None
86X  A1004 ( 4.2A)
 0.33A 4olfA-5xiiA:
52.6		 4olfA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 12 PHE A 415
HIS A 491
PHE A 534
THR A 540
SER A 588
 86X  A1004 (-3.6A)
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
None
86X  A1004 (-3.6A)
 1.36A 4olfA-5xiiA:
52.6		 4olfA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
ARG A 470
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.7A)
 0.27A 4olfA-5xiiA:
52.6		 4olfA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
ARG A 470
TRP A 487
HIS A 491
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.33A 4q15A-5xiiA:
50.4		 4q15A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
TRP A 487
HIS A 491
PHE A 534
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.27A 4q15A-5xiiA:
50.4		 4q15A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.36A 4q15A-5xiiA:
50.4		 4q15A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
ARG A 470
TRP A 487
GLU A 489
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.31A 4q15B-5xiiA:
51.3		 4q15B-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
TRP A 487
GLU A 489
PHE A 534
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.24A 4q15B-5xiiA:
51.3		 4q15B-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.37A 4q15B-5xiiA:
51.3		 4q15B-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 12 GLU A 472
ARG A 470
GLU A 489
HIS A 491
SER A 588
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
 1.38A 4ydqA-5xiiA:
53.3		 4ydqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		11 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
GLU A 489
HIS A 491
PHE A 534
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.29A 4ydqA-5xiiA:
53.3		 4ydqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		10 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
PHE A 534
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.62A 4ydqA-5xiiA:
53.3		 4ydqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.31A 4ydqA-5xiiA:
53.3		 4ydqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 GLU A 472
THR A 439
ARG A 470
GLU A 489
HIS A 491
SER A 588
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
 1.41A 4ydqB-5xiiA:
52.8		 4ydqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		11 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
GLU A 489
HIS A 491
PHE A 534
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.46A 4ydqB-5xiiA:
52.8		 4ydqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		9 / 12 VAL A 419
PRO A 438
THR A 439
ARG A 470
TRP A 487
HIS A 491
PHE A 534
SER A 588
GLY A 590
 86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.66A 4ydqB-5xiiA:
52.8		 4ydqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.35A 4ydqB-5xiiA:
52.8		 4ydqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 GLU A 472
ARG A 470
TRP A 487
GLU A 489
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.29A 5f9zA-5xiiA:
51.8		 5f9zA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		10 / 12 LEU A 405
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
PHE A 534
SER A 588
GLY A 590
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.26A 5f9zA-5xiiA:
51.8		 5f9zA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.24A 5f9zA-5xiiA:
51.8		 5f9zA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 GLU A 472
ARG A 470
TRP A 487
GLU A 489
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.29A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		10 / 12 LEU A 405
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
PHE A 534
SER A 588
GLY A 590
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.28A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 LEU A 405
SER A 416
VAL A 419
GLU A 489
PHE A 534
SER A 588
 None
None
86X  A1004 (-4.2A)
None
86X  A1004 (-3.6A)
86X  A1004 (-3.6A)
 1.20A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
THR A 558
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.24A 5f9zB-5xiiA:
51.9		 5f9zB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		9 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
PHE A 534
THR A 558
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.65A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		11 / 12 PHE A 415
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 86X  A1004 (-3.6A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.40A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 THR A 439
GLU A 441
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.7A)
 0.07A 5xioA-5xiiA:
51.7		 5xioA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		8 / 12 GLU A 472
THR A 439
ARG A 470
GLU A 489
HIS A 491
PHE A 534
THR A 558
HIS A 560
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 1.25A 5xioB-5xiiA:
51.8		 5xioB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
HIS A 560
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.47A 5xioB-5xiiA:
51.8		 5xioB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
ARG A 470
HIS A 491
THR A 558
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.38A 5xipA-5xiiA:
53.0		 5xipA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.56A 5xipA-5xiiA:
53.0		 5xipA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 GLU A 441
TRP A 487
HIS A 560
 86X  A1004 (-3.0A)
None
86X  A1004 (-3.7A)
 0.25A 5xipA-5xiiA:
53.0		 5xipA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		8 / 12 GLU A 472
THR A 439
ARG A 470
TRP A 487
HIS A 491
PHE A 534
THR A 558
HIS A 560
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 1.23A 5xipB-5xiiA:
52.7		 5xipB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
GLU A 441
ARG A 470
TRP A 487
HIS A 491
PHE A 534
THR A 558
HIS A 560
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.7A)
 0.52A 5xipB-5xiiA:
52.7		 5xipB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
TRP A 487
GLU A 489
HIS A 491
THR A 558
GLY A 590
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 ( 4.2A)
 1.08A 5xipC-5xiiA:
52.5		 5xipC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 LEU A 405
GLU A 418
VAL A 419
GLU A 441
HIS A 491
PHE A 534
THR A 540
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-3.0A)
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
None
 1.48A 5xipC-5xiiA:
52.5		 5xipC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
GLU A 418
VAL A 419
PRO A 438
THR A 439
GLU A 441
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
GLY A 590
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 ( 4.2A)
 0.34A 5xipC-5xiiA:
52.5		 5xipC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 12 VAL A 419
PRO A 438
THR A 439
GLU A 489
PHE A 566
 86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
None
None
 1.22A 5xipC-5xiiA:
52.5		 5xipC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
GLU A 441
ARG A 470
TRP A 487
GLU A 489
TRP A 589
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
None
None
 1.37A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 LEU A 405
GLU A 418
VAL A 419
GLU A 441
PHE A 534
THR A 540
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-3.0A)
86X  A1004 (-3.6A)
None
 1.48A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
GLU A 418
VAL A 419
PRO A 438
THR A 439
GLU A 441
ARG A 470
TRP A 487
GLU A 489
PHE A 534
THR A 558
TRP A 589
 None
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
None
 0.39A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		6 / 12 VAL A 419
PRO A 438
THR A 439
GLU A 489
PHE A 566
TRP A 589
 86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
None
None
None
 1.40A 5xipD-5xiiA:
52.6		 5xipD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		8 / 12 GLU A 472
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 ANP  A1001 (-3.4A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 1.11A 5xiqA-5xiiA:
57.6		 5xiqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
86X  A1004 ( 4.2A)
 0.20A 5xiqA-5xiiA:
57.6		 5xiqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
ARG A 470
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.7A)
 0.12A 5xiqA-5xiiA:
57.6		 5xiqA-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
ARG A 470
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
 1.28A 5xiqB-5xiiA:
55.5		 5xiqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
 0.23A 5xiqB-5xiiA:
55.5		 5xiqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 THR A 439
GLU A 441
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.7A)
 0.08A 5xiqB-5xiiA:
55.5		 5xiqB-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
THR A 439
ARG A 470
GLU A 489
HIS A 491
THR A 558
SER A 588
 ANP  A1001 (-3.4A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
 1.34A 5xiqC-5xiiA:
55.6		 5xiqC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 PHE A 415
GLU A 418
VAL A 419
PRO A 438
THR A 439
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
SER A 588
 86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
86X  A1004 (-3.6A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
 0.22A 5xiqC-5xiiA:
55.6		 5xiqC-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
ARG A 470
TRP A 487
GLU A 489
HIS A 491
THR A 558
GLY A 590
 ANP  A1001 (-3.4A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 ( 4.2A)
 1.27A 5xiqD-5xiiA:
56.3		 5xiqD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
ARG A 470
TRP A 487
GLU A 489
HIS A 491
PHE A 534
THR A 558
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
ANP  A1001 ( 2.9A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.6A)
86X  A1004 (-3.9A)
86X  A1004 ( 4.2A)
 0.27A 5xiqD-5xiiA:
56.3		 5xiqD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		5 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
THR A 540
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
None
 1.16A 5xiqD-5xiiA:
56.3		 5xiqD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		3 / 3 THR A 439
GLU A 441
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
86X  A1004 (-3.7A)
 0.10A 5xiqD-5xiiA:
56.3		 5xiqD-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		7 / 12 GLU A 472
GLU A 489
HIS A 491
THR A 558
SER A 588
TRP A 589
GLY A 590
 ANP  A1001 (-3.4A)
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
None
86X  A1004 ( 4.2A)
 1.06A 6mn8A-5xiiA:
45.0		 6mn8A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		12 / 12 LEU A 405
PHE A 415
GLU A 418
VAL A 419
PRO A 438
TRP A 487
GLU A 489
HIS A 491
THR A 558
SER A 588
TRP A 589
GLY A 590
 None
86X  A1004 (-3.6A)
MG  A1003 (-4.1A)
86X  A1004 (-4.2A)
86X  A1004 (-4.3A)
None
None
86X  A1004 ( 4.8A)
86X  A1004 (-3.9A)
86X  A1004 (-3.6A)
None
86X  A1004 ( 4.2A)
 0.44A 6mn8A-5xiiA:
45.0		 6mn8A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_1
(UNCHARACTERIZED
PROTEIN)		 5xii PROLYL-TRNA
SYNTHETASE (PRORS)
(Toxoplasma
gondii) 		4 / 4 THR A 439
GLU A 441
ARG A 470
HIS A 560
 86X  A1004 (-3.6A)
86X  A1004 (-3.0A)
ANP  A1001 ( 2.9A)
86X  A1004 (-3.7A)
 0.40A 6mn8A-5xiiA:
45.0		 6mn8A-5xiiA:
undetectable