SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '869'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1869_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
 ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
 0.01A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQT_A_ACTA1870_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 HIS A  57
PRO A  58
LYS A  59
ILE A  60
 ACT  A1869 (-3.7A)
ACT  A1870 (-3.3A)
ACT  A1870 (-4.8A)
FAD  A2457 ( 3.5A)
 0.31A 1lqtA-1lqtA:
66.0		 1lqtA-1lqtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LQU_A_ACTA1426_0
(FPRA)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  56
HIS A  57
ARG A 164
GLU A 214
 ACT  A1869 (-3.7A)
ACT  A1869 (-3.7A)
None
ACT  A1869 (-2.6A)
 0.54A 1lquA-1lqtA:
64.3		 1lquA-1lqtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2vmf BETA-MANNOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 414
VAL A 416
ARG A 507
VAL A 350
ALA A 357
 None
None
EDO  A1869 ( 3.7A)
None
None
 1.21A 1n4hA-2vmfA:
undetectable		 1n4hA-2vmfA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 129
TYR A 132
ASP A  56
LEU A  48
 FAD  A2457 ( 4.3A)
None
ACT  A1869 (-3.7A)
FAD  A2457 (-2.9A)
 1.18A 1pk2A-1lqtA:
undetectable		 1pk2A-1lqtA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Rattus
norvegicus) 		4 / 8 GLN A 357
GLN A 334
ILE A 351
SER A 211
 None
869  A1501 ( 3.8A)
None
None
 1.03A 2xz5B-1sqiA:
undetectable
2xz5E-1sqiA:
undetectable		 2xz5B-1sqiA:
21.43
2xz5E-1sqiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1lqt FPRA
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 132
ASP A 177
HIS A  57
 None
None
ACT  A1869 (-3.7A)
 0.91A 3e23A-1lqtA:
undetectable		 3e23A-1lqtA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dm7 50S RIBOSOMAL
PROTEIN L27
(Deinococcus
radiodurans) 		4 / 7 ILE T  36
PHE T  69
PHE T  45
GLY T  54
 A  X2333 ( 3.9A)
C  X 869 ( 3.5A)
None
C  X2343 ( 3.2A)
 0.96A 3em0B-5dm7T:
undetectable		 3em0B-5dm7T:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5ool 39S RIBOSOMAL
PROTEIN L35,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS 6 355
ARG 6 368
LYS 3 126
 None
G  A2860 ( 2.9A)
A  A2869 ( 3.4A)
 1.40A 3okxA-5ool6:
undetectable		 3okxA-5ool6:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Rattus
norvegicus) 		4 / 6 GLN A 357
GLN A 334
ILE A 351
SER A 211
 None
869  A1501 ( 3.8A)
None
None
 1.02A 3peoG-1sqiA:
undetectable		 3peoG-1sqiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE
(Rattus
norvegicus) 		5 / 12 GLY A 360
GLY A 362
SER A 366
VAL A 324
LEU A 332
 869  A1501 ( 4.4A)
None
None
None
None
 1.12A 5kocB-1sqiA:
undetectable		 5kocB-1sqiA:
21.94