SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '85C'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 GLN Z 100
GLY Z 354
HIS Z  57
HIS Z 378
 None
None
None
85C  Z 502 (-3.8A)
 0.87A 3ai8A-5hxbZ:
undetectable		 3ai8A-5hxbZ:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens) 		5 / 12 GLY X 627
ALA X 533
ILE X 626
LEU X 552
ILE X 538
 85C  Z 502 (-3.8A)
None
85C  Z 502 (-3.9A)
None
None
 1.13A 4aztA-5hxbX:
undetectable		 4aztA-5hxbX:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		10 / 10 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 357
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.50A 4ci1B-5hxbZ:
16.1		 4ci1B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		6 / 10 ASN Z 351
PRO Z 352
HIS Z 357
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.39A 4ci1B-5hxbZ:
16.1		 4ci1B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI2_B_LVYB1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		9 / 9 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.47A 4ci2B-5hxbZ:
21.5		 4ci2B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI2_B_LVYB1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 9 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.36A 4ci2B-5hxbZ:
21.5		 4ci2B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI3_B_Y70B1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		10 / 10 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 357
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.49A 4ci3B-5hxbZ:
50.9		 4ci3B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI3_B_Y70B1429_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 10 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.32A 4ci3B-5hxbZ:
50.9		 4ci3B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZ4_C_LVYC502_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		9 / 9 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.48A 4tz4C-5hxbZ:
52.6		 4tz4C-5hxbZ:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZ4_C_LVYC502_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 9 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.38A 4tz4C-5hxbZ:
52.6		 4tz4C-5hxbZ:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_A_EF2A504_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 4tzcA-5hxbZ:
9.9		 4tzcA-5hxbZ:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_C_EF2C502_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.42A 4tzcC-5hxbZ:
9.9		 4tzcC-5hxbZ:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.45A 4tzcB-5hxbZ:
9.6
4tzcD-5hxbZ:
9.8		 4tzcB-5hxbZ:
33.02
4tzcD-5hxbZ:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZU_A_Y70A504_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.42A 4tzuA-5hxbZ:
10.1		 4tzuA-5hxbZ:
97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZU_B_Y70B505_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 4tzuB-5hxbZ:
10.0
4tzuC-5hxbZ:
9.9		 4tzuB-5hxbZ:
97.22
4tzuC-5hxbZ:
97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZU_C_Y70C504_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.44A 4tzuB-5hxbZ:
10.0
4tzuC-5hxbZ:
9.9		 4tzuB-5hxbZ:
97.22
4tzuC-5hxbZ:
97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZU_D_Y70D503_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.48A 4tzuD-5hxbZ:
10.0		 4tzuD-5hxbZ:
97.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.53A 4v2yA-5hxbZ:
11.4		 4v2yA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.46A 4v2yB-5hxbZ:
11.5		 4v2yB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
 0.78A 4v2yC-5hxbZ:
10.9		 4v2yC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.57A 4v2yC-5hxbZ:
10.9		 4v2yC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.49A 4v2zA-5hxbZ:
11.4		 4v2zA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 8 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.47A 4v2zB-5hxbZ:
11.5		 4v2zB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
 0.77A 4v2zC-5hxbZ:
10.7		 4v2zC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.51A 4v2zC-5hxbZ:
10.7		 4v2zC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.54A 4v30A-5hxbZ:
11.5		 4v30A-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 8 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.48A 4v30B-5hxbZ:
11.4		 4v30B-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_C_LVYC151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.73A 4v30C-5hxbZ:
10.6		 4v30C-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		6 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.50A 4v32A-5hxbZ:
11.4		 4v32A-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		6 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.47A 4v32B-5hxbZ:
11.5		 4v32B-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
None
 0.72A 4v32C-5hxbZ:
10.7		 4v32C-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.54A 4v32C-5hxbZ:
10.7		 4v32C-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.73A 5amhA-5hxbZ:
11.7		 5amhA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.49A 5amiA-5hxbZ:
11.5		 5amiA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		6 / 8 ASN Z 351
PRO Z 352
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.47A 5amiB-5hxbZ:
11.6		 5amiB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.46A 5amjA-5hxbZ:
11.8		 5amjA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.42A 5amjB-5hxbZ:
11.6		 5amjB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 8 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.62A 5amkA-5hxbZ:
11.5		 5amkA-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.59A 5amkB-5hxbZ:
11.6		 5amkB-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ILE X 626
PHE Z 150
GLN Z 148
GLU Z 147
 85C  Z 502 (-3.9A)
None
None
None
 1.01A 5dqyA-5hxbX:
undetectable		 5dqyA-5hxbX:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FQD_B_LVYB1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens) 		9 / 11 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.58A 5fqdB-5hxbZ:
53.2
5fqdC-5hxbZ:
0.0		 5fqdB-5hxbZ:
99.26
5fqdC-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FQD_B_LVYB1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens) 		9 / 11 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.35A 5fqdB-5hxbZ:
53.2
5fqdC-5hxbZ:
0.0		 5fqdB-5hxbZ:
99.26
5fqdC-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens) 		10 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.59A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens) 		10 / 12 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.39A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 12 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.25A 5fqdE-5hxbZ:
51.4
5fqdF-5hxbZ:
undetectable		 5fqdE-5hxbZ:
99.26
5fqdF-5hxbZ:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.56A 5oh1A-5hxbZ:
11.4		 5oh1A-5hxbZ:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.52A 5oh1B-5hxbZ:
11.4		 5oh1B-5hxbZ:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
 0.76A 5oh1C-5hxbZ:
10.7		 5oh1C-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 8 PRO Z 352
GLU Z 377
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.61A 5oh1C-5hxbZ:
10.7		 5oh1C-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.46A 5oh3A-5hxbZ:
11.6		 5oh3A-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 7 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.45A 5oh3B-5hxbZ:
11.5		 5oh3B-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_A_EF2A501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizA-5hxbZ:
9.8		 5yizA-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_B_EF2B501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yizb-5hxbZ:
9.9		 5yizb-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_D_EF2D501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizD-5hxbZ:
9.8		 5yizD-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_E_EF2E501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yize-5hxbZ:
10.1		 5yize-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizG-5hxbZ:
9.8
5yizY-5hxbZ:
10.2		 5yizG-5hxbZ:
21.39
5yizY-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_H_EF2H501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yizh-5hxbZ:
9.9		 5yizh-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_J_EF2J501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yizJ-5hxbZ:
9.8		 5yizJ-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizk-5hxbZ:
10.1
5yizt-5hxbZ:
9.7		 5yizk-5hxbZ:
21.39
5yizt-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_M_EF2M501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizM-5hxbZ:
10.2		 5yizM-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_N_EF2N501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.38A 5yizn-5hxbZ:
9.8		 5yizn-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_P_EF2P501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yizP-5hxbZ:
9.9		 5yizP-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Q_EF2Q501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yizq-5hxbZ:
10.0		 5yizq-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_S_EF2S501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yizS-5hxbZ:
10.0		 5yizS-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yizk-5hxbZ:
10.1
5yizt-5hxbZ:
9.7		 5yizk-5hxbZ:
21.39
5yizt-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_V_EF2V501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.38A 5yizV-5hxbZ:
9.9		 5yizV-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yizG-5hxbZ:
9.8
5yizY-5hxbZ:
10.2		 5yizG-5hxbZ:
21.39
5yizY-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_A_EF2A501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.40A 5yj0A-5hxbZ:
9.8		 5yj0A-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_B_EF2B501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0b-5hxbZ:
9.9		 5yj0b-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_D_EF2D501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.42A 5yj0D-5hxbZ:
9.7		 5yj0D-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_E_EF2E501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.40A 5yj0e-5hxbZ:
10.1		 5yj0e-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj0G-5hxbZ:
9.8
5yj0Y-5hxbZ:
10.2		 5yj0G-5hxbZ:
21.39
5yj0Y-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_H_EF2H501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.38A 5yj0h-5hxbZ:
9.9		 5yj0h-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_J_EF2J501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0J-5hxbZ:
9.8		 5yj0J-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0k-5hxbZ:
10.2
5yj0t-5hxbZ:
9.7		 5yj0k-5hxbZ:
21.39
5yj0t-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_M_EF2M501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.40A 5yj0M-5hxbZ:
10.2		 5yj0M-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_N_EF2N501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0n-5hxbZ:
9.8		 5yj0n-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_P_EF2P501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.38A 5yj0P-5hxbZ:
9.9		 5yj0P-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Q_EF2Q501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0q-5hxbZ:
10.0		 5yj0q-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_S_EF2S501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj0S-5hxbZ:
10.0		 5yj0S-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj0k-5hxbZ:
10.2
5yj0t-5hxbZ:
9.7		 5yj0k-5hxbZ:
21.39
5yj0t-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_V_EF2V501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.38A 5yj0V-5hxbZ:
9.9		 5yj0V-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj0G-5hxbZ:
9.8
5yj0Y-5hxbZ:
10.2		 5yj0G-5hxbZ:
21.39
5yj0Y-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_A_6ELA501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.50A 5yj1A-5hxbZ:
9.8		 5yj1A-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_B_6ELB501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.45A 5yj1b-5hxbZ:
9.9		 5yj1b-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_D_6ELD501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.48A 5yj1D-5hxbZ:
9.8		 5yj1D-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_E_6ELE501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.42A 5yj1e-5hxbZ:
9.9		 5yj1e-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.48A 5yj1G-5hxbZ:
9.7
5yj1Y-5hxbZ:
9.9		 5yj1G-5hxbZ:
27.62
5yj1Y-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 TRP Z 386
TRP Z 400
PHE Z 402
HIS Z 353
 85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.9A)
 1.23A 5yj1G-5hxbZ:
9.7
5yj1Y-5hxbZ:
9.9		 5yj1G-5hxbZ:
27.62
5yj1Y-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_H_6ELH501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yj1h-5hxbZ:
9.8		 5yj1h-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_J_6ELJ501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj1J-5hxbZ:
9.8		 5yj1J-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yj1k-5hxbZ:
10.1
5yj1t-5hxbZ:
9.7		 5yj1k-5hxbZ:
27.62
5yj1t-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_M_6ELM501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.43A 5yj1M-5hxbZ:
9.9		 5yj1M-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_N_6ELN501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj1n-5hxbZ:
9.8		 5yj1n-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_P_6ELP501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.44A 5yj1P-5hxbZ:
9.9		 5yj1P-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Q_6ELQ501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.44A 5yj1q-5hxbZ:
9.9		 5yj1q-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_S_6ELS501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.42A 5yj1S-5hxbZ:
9.9		 5yj1S-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 HIS Z 353
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.9A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 1.25A 5yj1k-5hxbZ:
10.1
5yj1t-5hxbZ:
9.7		 5yj1k-5hxbZ:
27.62
5yj1t-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 8 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.51A 5yj1k-5hxbZ:
10.1
5yj1t-5hxbZ:
9.7		 5yj1k-5hxbZ:
27.62
5yj1t-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_V_6ELV501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 5 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.39A 5yj1V-5hxbZ:
9.8		 5yj1V-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		4 / 7 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.40A 5yj1G-5hxbZ:
9.7
5yj1Y-5hxbZ:
9.9		 5yj1G-5hxbZ:
27.62
5yj1Y-5hxbZ:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_B_Y70B502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.64A 6h0fB-5hxbZ:
30.7
6h0fC-5hxbZ:
0.0		 6h0fB-5hxbZ:
62.90
6h0fC-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_B_Y70B502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.44A 6h0fB-5hxbZ:
30.7
6h0fC-5hxbZ:
0.0		 6h0fB-5hxbZ:
62.90
6h0fC-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_E_Y70E502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.65A 6h0fE-5hxbZ:
30.7
6h0fF-5hxbZ:
0.0		 6h0fE-5hxbZ:
62.90
6h0fF-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_E_Y70E502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.45A 6h0fE-5hxbZ:
30.7
6h0fF-5hxbZ:
0.0		 6h0fE-5hxbZ:
62.90
6h0fF-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_H_Y70H502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.62A 6h0fH-5hxbZ:
30.7
6h0fI-5hxbZ:
0.0		 6h0fH-5hxbZ:
62.90
6h0fI-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_H_Y70H502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.40A 6h0fH-5hxbZ:
30.7
6h0fI-5hxbZ:
0.0		 6h0fH-5hxbZ:
62.90
6h0fI-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_K_Y70K502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.64A 6h0fK-5hxbZ:
30.5
6h0fL-5hxbZ:
0.0		 6h0fK-5hxbZ:
62.90
6h0fL-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0F_K_Y70K502_0
(IKAROS (IKZF1)
PROTEIN CEREBLON)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		9 / 12 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.45A 6h0fK-5hxbZ:
30.5
6h0fL-5hxbZ:
0.0		 6h0fK-5hxbZ:
62.90
6h0fL-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0G_B_Y70B502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		10 / 11 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.60A 6h0gB-5hxbZ:
51.9
6h0gC-5hxbZ:
undetectable		 6h0gB-5hxbZ:
62.90
6h0gC-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0G_B_Y70B502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		6 / 11 PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 386
GLN X 534
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.4A)
85C  Z 502 ( 4.0A)
 1.41A 6h0gB-5hxbZ:
51.9
6h0gC-5hxbZ:
undetectable		 6h0gB-5hxbZ:
62.90
6h0gC-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5hxb PROTEIN CEREBLON
(Homo
sapiens) 		5 / 12 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.33A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		11 / 12 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.55A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON
(Homo
sapiens;
Homo
sapiens) 		7 / 12 PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 386
GLN X 534
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 ( 4.0A)
 1.26A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65