SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '83M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 8 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.73A 1f5lA-5ubkA:
undetectable		 1f5lA-5ubkA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.05A 1kiaA-5ubkA:
undetectable		 1kiaA-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1kiaB-5ubkA:
undetectable		 1kiaB-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1kiaC-5ubkA:
undetectable		 1kiaC-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1nbhB-5ubkA:
undetectable		 1nbhB-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.11A 1nbiA-5ubkA:
undetectable		 1nbiA-5ubkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.10A 1nbiB-5ubkA:
undetectable		 1nbiB-5ubkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.76A 1tnlA-5ubkA:
undetectable		 1tnlA-5ubkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.76A 2otvA-5ubkA:
undetectable		 2otvA-5ubkA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 483
THR A 189
TRP A 162
 None
None
83M  A 801 (-4.4A)
 1.05A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  52
PRO A  54
VAL A  55
ASN A  57
LEU A 688
 None
None
None
83M  A 801 ( 4.0A)
None
 1.09A 3p2kC-5ubkA:
undetectable		 3p2kC-5ubkA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.74A 3rxfA-5ubkA:
undetectable		 3rxfA-5ubkA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 695
GLY A 702
PRO A 130
LEU A 708
ASN A 152
 83M  A 801 ( 4.4A)
None
None
None
None
 1.21A 4x61A-5ubkA:
undetectable		 4x61A-5ubkA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbC-5ubkA:
42.0		 4yfbC-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbF-5ubkA:
42.1		 4yfbF-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.51A 4yfbI-5ubkA:
36.9		 4yfbI-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbL-5ubkA:
41.5		 4yfbL-5ubkA:
30.39