SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7XL'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_B_BEZB1162_0 (PEROXIREDOXIN 5)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	4 / 8	PRO A 17 THR A 124 PRO A 125 GLY A 126	None 7XL A 201 (-4.4A) None None	0.66A	1h4oB-5x3dA: undetectable	1h4oB-5x3dA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_G_BEZG1162_0 (PEROXIREDOXIN 5)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	4 / 8	PRO A 17 THR A 124 PRO A 125 GLY A 126	None 7XL A 201 (-4.4A) None None	0.66A	1h4oG-5x3dA: undetectable	1h4oG-5x3dA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNA SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 11	GLY A 9 HIS A 16 HIS A 19 GLY A 92 ASP A 94	7XL A 201 ( 4.5A) 7XL A 201 (-4.4A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.65A	1jzsA-5x3dA: undetectable	1jzsA-5x3dA: 11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PG2_A_ADNA552_1 (METHIONYL-TRNA SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 11	HIS A 16 GLY A 18 HIS A 19 GLY A 92 ASP A 94	7XL A 201 (-4.4A) 7XL A 201 ( 3.7A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.48A	1pg2A-5x3dA: 5.4	1pg2A-5x3dA: 14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 11	HIS A 16 GLY A 18 HIS A 19 GLY A 92 ASP A 94	7XL A 201 (-4.4A) 7XL A 201 ( 3.7A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.35A	2x1lA-5x3dA: 6.2	2x1lA-5x3dA: 14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 12	HIS A 16 GLY A 18 HIS A 19 GLY A 92 ASP A 94	7XL A 201 (-4.4A) 7XL A 201 ( 3.7A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.29A	2x1lB-5x3dA: 6.2	2x1lB-5x3dA: 14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 11	HIS A 16 GLY A 18 HIS A 19 GLY A 92 ASP A 94	7XL A 201 (-4.4A) 7XL A 201 ( 3.7A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.32A	2x1lC-5x3dA: 3.1	2x1lC-5x3dA: 14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFN_A_ROCA401_2 (HIV-1 PROTEASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	4 / 7	GLY A 18 ILE A 20 VAL A 8 VAL A 90	7XL A 201 ( 3.7A) None None None	0.79A	3ufnB-5x3dA: undetectable	3ufnB-5x3dA: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	5x3d	PHOSPHOENOLPYRUVATE PHOSPHOMUTASE (Streptomyces wedmorensis)	5 / 12	HIS A 16 GLY A 18 HIS A 19 GLY A 92 ASP A 94	7XL A 201 (-4.4A) 7XL A 201 ( 3.7A) 7XL A 201 (-4.5A) 7XL A 201 (-3.0A) 7XL A 201 (-3.2A)	0.99A	5hg0B-5x3dA: 8.6	5hg0B-5x3dA: 18.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H4O_B_BEZB1162_0","PEROXIREDOXIN 5","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",4,"PRO A  17;THR A 124;PRO A 125;GLY A 126","None;7XL A 201 (-4.4A);None;None","0.66A","1h4oB-5x3dA:undetectable",null],["1H4O_G_BEZG1162_0","PEROXIREDOXIN 5","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",4,"PRO A  17;THR A 124;PRO A 125;GLY A 126","None;7XL A 201 (-4.4A);None;None","0.66A","1h4oG-5x3dA:undetectable","1h4oB-5x3dA:24.10"],["1JZS_A_MRCA1301_1","ISOLEUCYL-TRNA SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"GLY A   9;HIS A  16;HIS A  19;GLY A  92;ASP A  94","7XL A 201 ( 4.5A);7XL A 201 (-4.4A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.65A","1jzsA-5x3dA:undetectable","1h4oG-5x3dA:24.10"],["1PG2_A_ADNA552_1","METHIONYL-TRNA SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"HIS A  16;GLY A  18;HIS A  19;GLY A  92;ASP A  94","7XL A 201 (-4.4A);7XL A 201 ( 3.7A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.48A","1pg2A-5x3dA:5.4","1jzsA-5x3dA:11.37"],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"HIS A  16;GLY A  18;HIS A  19;GLY A  92;ASP A  94","7XL A 201 (-4.4A);7XL A 201 ( 3.7A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.35A","2x1lA-5x3dA:6.2","1pg2A-5x3dA:14.18"],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"HIS A  16;GLY A  18;HIS A  19;GLY A  92;ASP A  94","7XL A 201 (-4.4A);7XL A 201 ( 3.7A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.29A","2x1lB-5x3dA:6.2","2x1lA-5x3dA:14.69"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"HIS A  16;GLY A  18;HIS A  19;GLY A  92;ASP A  94","7XL A 201 (-4.4A);7XL A 201 ( 3.7A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.32A","2x1lC-5x3dA:3.1","2x1lB-5x3dA:14.69"],["3UFN_A_ROCA401_2","HIV-1 PROTEASE;HIV-1 PROTEASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",4,"GLY A  18;ILE A  20;VAL A   8;VAL A  90","7XL A 201 ( 3.7A);None;None;None","0.79A","3ufnB-5x3dA:undetectable","2x1lC-5x3dA:14.69"],["5HG0_B_SAMB301_0","PANTOTHENATE SYNTHETASE","5x3d","PHOSPHOENOLPYRUVATE PHOSPHOMUTASE","Streptomyces wedmorensis",5,"HIS A  16;GLY A  18;HIS A  19;GLY A  92;ASP A  94","7XL A 201 (-4.4A);7XL A 201 ( 3.7A);7XL A 201 (-4.5A);7XL A 201 (-3.0A);7XL A 201 (-3.2A)","0.99A","5hg0B-5x3dA:8.6","3ufnB-5x3dA:19.14"]]