SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7WY'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
6 / 7 TRP A 370
PRO A 371
LEU A 381
LEU A 383
ASN A 429
MET A 438
None
7WY  A 501 (-4.4A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
0.39A 3u5jA-5u6vA:
17.9
3u5jA-5u6vA:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
7 / 8 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
0.41A 3u5kA-5u6vA:
18.0
3u5kA-5u6vA:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
6 / 7 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
0.38A 3u5kB-5u6vA:
18.1
3u5kB-5u6vA:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
7 / 8 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
0.48A 3u5kC-5u6vA:
17.6
3u5kC-5u6vA:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
7 / 8 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
0.48A 3u5kD-5u6vA:
18.0
3u5kD-5u6vA:
40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
4 / 5 VAL A 376
LEU A 381
LEU A 383
ASN A 429
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
0.39A 4a9jA-5u6vA:
19.2
4a9jA-5u6vA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
4 / 5 VAL A 376
LEU A 381
LEU A 383
ASN A 429
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
0.33A 4a9jB-5u6vA:
19.2
4a9jB-5u6vA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
4 / 5 VAL A 376
LEU A 381
LEU A 383
ASN A 429
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
0.33A 4a9jC-5u6vA:
19.5
4a9jC-5u6vA:
39.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
5 / 6 VAL A 376
LEU A 381
TYR A 428
ASN A 429
VAL A 435
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 (-4.1A)
0.58A 4a9kA-5u6vA:
17.7
4a9kA-5u6vA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
4 / 5 VAL A 376
LEU A 381
ASN A 429
VAL A 435
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
7WY  A 501 (-3.4A)
7WY  A 501 (-4.1A)
0.46A 4a9kB-5u6vA:
18.1
4a9kB-5u6vA:
36.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
7 / 9 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
0.40A 4c66A-5u6vA:
18.0
4c66A-5u6vA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
4 / 6 PRO A 371
VAL A 376
TYR A 386
ASN A 429
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
None
7WY  A 501 (-3.4A)
0.65A 5pbeA-5u6vA:
17.0
5pbeA-5u6vA:
32.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo
sapiens)
7 / 8 PRO A 371
VAL A 376
LEU A 381
LEU A 383
CYH A 425
TYR A 428
ASN A 429
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 ( 3.8A)
None
7WY  A 501 (-3.4A)
0.39A 5y1yA-5u6vA:
18.1
5y1yA-5u6vA:
41.05