SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7O9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 465
GLY A 466
VAL A 312
ALA A 383
 7O9  A 602 (-3.8A)
None
None
None
None
 0.72A 1gs4A-5mjuA:
undetectable		 1gs4A-5mjuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		4 / 4 LEU A 349
PRO A 350
LEU A  99
ARG A 368
 7O9  A 602 (-3.5A)
None
None
None
 1.40A 1hrkB-5mjuA:
undetectable		 1hrkB-5mjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		5 / 12 TYR A 127
ILE A 316
GLY A 466
ALA A 375
GLY A 472
 6Z6  A 601 (-4.3A)
None
None
7O9  A 602 (-3.6A)
None
 1.20A 1kiaB-5mjuA:
undetectable		 1kiaB-5mjuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		4 / 6 GLU A 283
ARG A 459
ASP A 452
GLY A 427
 None
7O9  A 602 (-4.0A)
None
7O9  A 602 (-3.7A)
 0.84A 1n13H-5mjuA:
undetectable
1n13K-5mjuA:
undetectable		 1n13H-5mjuA:
12.65
1n13K-5mjuA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		4 / 7 ASP A 452
GLY A 427
GLU A 283
ARG A 459
 None
7O9  A 602 (-3.7A)
None
7O9  A 602 (-4.0A)
 0.91A 1n13G-5mjuA:
undetectable
1n13J-5mjuA:
undetectable		 1n13G-5mjuA:
8.30
1n13J-5mjuA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		4 / 4 LEU A 349
PRO A 350
LEU A  99
ARG A 368
 7O9  A 602 (-3.5A)
None
None
None
 1.40A 2hrcB-5mjuA:
undetectable		 2hrcB-5mjuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		5 / 12 ASN A 463
LEU A 465
GLY A 466
VAL A 312
ALA A 383
 7O9  A 602 (-3.8A)
None
None
None
None
 0.87A 2oz7A-5mjuA:
undetectable		 2oz7A-5mjuA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		4 / 5 THR A 367
LEU A 371
THR A 460
MET A 461
 None
None
7O9  A 602 (-3.3A)
None
 1.48A 4mbsB-5mjuA:
2.0		 4mbsB-5mjuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		5 / 9 LEU A 371
SER A 345
THR A 348
LEU A 349
ILE A 351
 None
7O9  A 602 (-2.7A)
None
7O9  A 602 (-3.5A)
None
 1.19A 4ubsA-5mjuA:
undetectable		 4ubsA-5mjuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		3 / 3 MET A 379
ASP A 456
PHE A 458
 7O9  A 602 (-4.3A)
7O9  A 602 (-3.5A)
None
 1.07A 4xeyA-5mjuA:
undetectable		 4xeyA-5mjuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		3 / 3 MET A 379
ASP A 456
PHE A 458
 7O9  A 602 (-4.3A)
7O9  A 602 (-3.5A)
None
 1.01A 4xeyB-5mjuA:
undetectable		 4xeyB-5mjuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens) 		5 / 10 GLY A 138
GLY A 304
VAL A 462
ARG A 459
ALA A 383
 None
None
None
7O9  A 602 (-4.0A)
None
 1.15A 5o96E-5mjuA:
undetectable
5o96F-5mjuA:
undetectable		 5o96E-5mjuA:
20.00
5o96F-5mjuA:
20.00