SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7NA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 10 GLY A 177
ASP A 200
LEU A 201
ALA A 243
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
None
 0.21A 1fpqA-3i58A:
19.9		 1fpqA-3i58A:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 LEU A 154
ALA A 243
ILE A 273
GLY A 178
 SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
None
SAH  A 401 (-3.6A)
 0.83A 1sv9A-3i58A:
undetectable		 1sv9A-3i58A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 GLY A 106
ARG A 105
TYR A 293
 None
None
7NA  A 402 ( 4.5A)
 0.78A 2opxA-3i58A:
4.5		 2opxA-3i58A:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 PHE A 146
MET A 150
HIS A 153
GLY A 177
LEU A 201
PRO A 204
ALA A 243
 None
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
 0.96A 3i5uA-3i58A:
49.7		 3i5uA-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		12 / 12 TRP A 133
PHE A 146
MET A 150
HIS A 153
LEU A 154
GLY A 178
GLY A 179
LEU A 201
PRO A 204
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
None
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.21A 3i5uA-3i58A:
49.7		 3i5uA-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 MET A 150
HIS A 153
GLY A 177
GLY A 178
LEU A 201
ALA A 243
 7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.28A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 MET A 150
HIS A 153
GLY A 177
LEU A 201
PRO A 204
ALA A 243
 7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
 1.02A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		12 / 12 TRP A 133
MET A 150
HIS A 153
LEU A 154
GLY A 178
GLY A 179
LEU A 201
PRO A 204
SER A 227
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.3A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.20A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		10 / 12 TRP A 133
MET A 150
HIS A 153
LEU A 154
GLY A 178
LEU A 201
SER A 227
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.3A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.91A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
ASP A 200
LEU A 201
ALA A 243
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.11A 4lg1A-3i58A:
12.6		 4lg1A-3i58A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
ASP A 200
LEU A 201
ALA A 243
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.13A 4lg1C-3i58A:
12.4		 4lg1C-3i58A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 8 ASP A 147
ASP A 175
SER A 180
GLY A 182
ALA A 243
 None
SAH  A 401 ( 4.2A)
None
None
7NA  A 402 ( 3.7A)
 1.40A 4m48A-3i58A:
undetectable		 4m48A-3i58A:
21.52