SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7N5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 11 HIS A  91
ASN A 305
ALA A  15
VAL A 286
LEU A  25
 7N5  A 413 (-3.8A)
None
7N5  A 413 ( 4.6A)
None
None
 1.40A 3jwqB-5mh5A:
undetectable
3jwqC-5mh5A:
undetectable		 3jwqB-5mh5A:
12.92
3jwqC-5mh5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5mh5 D-2-HYDROXYACID
DEHYDROGENASE
(Haloferax
mediterranei) 		5 / 12 HIS A  91
ALA A 277
SER A 276
GLY A  68
GLY A 144
 7N5  A 413 (-3.8A)
NAP  A 414 (-3.7A)
NAP  A 414 (-3.3A)
NAP  A 414 ( 3.6A)
NAP  A 414 (-3.2A)
 1.22A 4uilH-5mh5A:
undetectable
4uilL-5mh5A:
undetectable		 4uilH-5mh5A:
undetectable
4uilL-5mh5A:
undetectable