SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7MN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 GLY B 233
GLY B 232
SER B 235
LEU B 304
LEU B 188
 7MN  B   2 (-3.7A)
7MN  B   2 ( 3.2A)
7MN  B   2 (-2.7A)
None
None
 1.10A 1ya4B-3pr2B:
undetectable		 1ya4B-3pr2B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 11 HIS B  86
VAL B 231
GLY B 232
ILE B 228
ALA B 229
 7MN  B   2 (-4.0A)
7MN  B   2 ( 4.5A)
7MN  B   2 ( 3.2A)
None
None
 1.15A 2yy8A-3pr2B:
2.4
2yy8B-3pr2B:
undetectable		 2yy8A-3pr2B:
19.21
2yy8B-3pr2B:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 11 ALA B 108
GLY B 135
GLY B 111
ILE B 132
ASP B 138
 None
None
7MN  B   2 (-3.7A)
None
None
 1.09A 4dcmA-3pr2B:
2.5		 4dcmA-3pr2B:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		4 / 6 ARG B 379
GLY B 378
ASN B  89
GLN B 142
 None
7MN  B   2 ( 3.7A)
None
None
 1.05A 4g0vB-3pr2B:
undetectable		 4g0vB-3pr2B:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.32A 4hvcB-3pr2B:
undetectable		 4hvcB-3pr2B:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.28A 4q15A-3pr2B:
undetectable		 4q15A-3pr2B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.27A 4q15B-3pr2B:
undetectable		 4q15B-3pr2B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.26A 4ydqA-3pr2B:
undetectable		 4ydqA-3pr2B:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		4 / 7 LEU B 188
GLY B 233
GLY B 234
ILE B 238
 None
7MN  B   2 (-3.7A)
7MN  B   2 (-3.4A)
None
 0.74A 4yjiA-3pr2B:
undetectable		 4yjiA-3pr2B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 ALA B 108
GLY B 189
GLY B 116
SER B 119
LEU B 128
 None
7MN  B   2 ( 3.8A)
None
None
None
 1.03A 5gwxA-3pr2B:
undetectable		 5gwxA-3pr2B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.26A 5xipA-3pr2B:
undetectable		 5xipA-3pr2B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.24A 5xipC-3pr2B:
undetectable		 5xipC-3pr2B:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.29A 5xiqA-3pr2B:
undetectable		 5xiqA-3pr2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN
(Salmonella
enterica) 		5 / 12 LEU B  25
VAL B  17
PRO B 194
PHE B   9
GLY B 234
 None
None
None
None
7MN  B   2 (-3.4A)
 1.26A 5xiqD-3pr2B:
undetectable		 5xiqD-3pr2B:
22.16