SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7M8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 TRP A1526
PRO A1527
VAL A1532
ASN A1583
 None
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 (-3.1A)
 0.46A 3u5kA-5mg2A:
13.1		 3u5kA-5mg2A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 7 TRP A1526
PRO A1527
VAL A1532
ASN A1583
 None
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 (-3.1A)
 0.41A 3u5kB-5mg2A:
12.9		 3u5kB-5mg2A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 TRP A1526
PRO A1527
VAL A1532
ASN A1583
 None
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 (-3.1A)
 0.43A 3u5kC-5mg2A:
13.0		 3u5kC-5mg2A:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 TRP A1526
PRO A1527
VAL A1532
ASN A1583
 None
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 (-3.1A)
 0.48A 3u5kD-5mg2A:
13.1		 3u5kD-5mg2A:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		5 / 6 PRO A1527
VAL A1532
VAL A1537
TYR A1540
ASN A1583
 7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
None
None
7M8  A1704 (-3.1A)
 0.67A 5pbeA-5mg2A:
13.7		 5pbeA-5mg2A:
32.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens) 		4 / 8 PRO A1527
VAL A1532
TYR A1582
ASN A1583
 7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 ( 4.7A)
7M8  A1704 (-3.1A)
 0.52A 5y1yA-5mg2A:
13.1		 5y1yA-5mg2A:
29.10