SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7LV'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 9 GLY A  18
VAL A  25
ALA A  38
TYR A  88
LEU A 139
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
0.49A 1muoA-5tvtA:
11.3
1muoA-5tvtA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  57
LEU A  61
GLY A  92
LEU A 139
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
1.01A 1t46A-5tvtA:
22.2
1t46A-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 ALA A  38
GLU A  57
LEU A  61
CYH A  89
HIS A 130
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
0.69A 1uwhA-5tvtA:
23.7
1uwhA-5tvtA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 12 ALA A  38
LYS A  40
GLU A  57
LEU A  61
CYH A  89
HIS A 130
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
0.71A 1uwhB-5tvtA:
23.6
1uwhB-5tvtA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 7 ILE A  17
LEU A  61
ILE A  69
ASP A 150
7LV  A 401 (-4.3A)
None
None
7LV  A 401 (-4.2A)
0.89A 1uwjA-5tvtA:
7.3
1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 7 ILE A  17
LYS A  40
LEU A  61
ILE A  69
7LV  A 401 (-4.3A)
7LV  A 401 (-3.0A)
None
None
0.75A 1uwjA-5tvtA:
7.3
1uwjA-5tvtA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 11 GLY A  18
GLY A  20
VAL A  25
ALA A  38
TYR A  88
LEU A 139
7LV  A 401 ( 3.9A)
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
0.64A 2evaA-5tvtA:
23.5
2evaA-5tvtA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 12 GLY A  18
VAL A  25
ALA A  38
LEU A  86
TYR A  88
ASP A 150
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 ( 4.2A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.2A)
0.52A 2wgjA-5tvtA:
22.6
2wgjA-5tvtA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
GLY A  92
LEU A 139
7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
None
7LV  A 401 (-4.9A)
0.85A 2y6oA-5tvtA:
23.1
2y6oA-5tvtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 11 VAL A  25
ALA A  38
TYR A  88
CYH A  89
GLY A  92
LEU A 139
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
0.40A 3g0eA-5tvtA:
21.4
3g0eA-5tvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 11 VAL A  25
ALA A  38
TYR A  88
CYH A  89
GLY A  92
LEU A 139
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
0.39A 3g0fA-5tvtA:
22.4
3g0fA-5tvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 10 VAL A  25
ALA A  38
TYR A  88
CYH A  89
GLY A  92
LEU A 139
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
0.43A 3g0fB-5tvtA:
22.4
3g0fB-5tvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 VAL A  25
ALA A  38
LYS A  40
CYH A  89
PHE A 151
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
None
0.79A 3og7A-5tvtA:
23.3
3og7A-5tvtA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 GLY A  18
VAL A  25
ALA A  38
LYS A  40
LEU A  61
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
0.52A 3ohtB-5tvtA:
6.4
3ohtB-5tvtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 VAL A  25
ALA A  38
GLU A  57
MET A  84
TYR A  88
LEU A 139
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
1.22A 4bkjA-5tvtA:
22.0
4bkjA-5tvtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
9 / 12 VAL A  25
ALA A  38
ASP A  96
ASP A 132
LYS A 134
ASN A 137
LEU A 139
ILE A 149
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
None
None
None
None
7LV  A 401 (-4.9A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
0.77A 4i41A-5tvtA:
27.7
4i41A-5tvtA:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 11 ALA A  38
LEU A  86
GLU A 136
LEU A 139
ILE A 149
ASP A 150
7LV  A 401 (-3.4A)
7LV  A 401 ( 4.2A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
1.16A 4iaaA-5tvtA:
27.7
4iaaA-5tvtA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 11 VAL A  25
ALA A  38
LYS A  40
LEU A  86
LEU A 139
ILE A 149
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 ( 4.2A)
7LV  A 401 (-4.9A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
0.64A 4iaaA-5tvtA:
27.7
4iaaA-5tvtA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 12 GLY A  18
VAL A  25
ALA A  38
LEU A  72
GLY A  92
GLU A  93
LEU A 139
ILE A 149
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
None
None
7LV  A 401 ( 4.7A)
7LV  A 401 (-4.9A)
7LV  A 401 (-3.6A)
0.38A 4ifgA-5tvtA:
24.4
4ifgA-5tvtA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
LEU A 139
ASP A 150
7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.74A 4qmnA-5tvtA:
28.3
4qmnA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 11 ILE A  17
ALA A  38
LYS A  40
GLU A  57
TYR A  88
LEU A 139
ASP A 150
7LV  A 401 (-4.3A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.83A 4qmsA-5tvtA:
28.3
4qmsA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 12 ILE A  17
GLY A  18
VAL A  25
ALA A  38
TYR A  88
LEU A 139
7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
0.39A 4qmzA-5tvtA:
28.4
4qmzA-5tvtA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  57
CYH A  89
LEU A 139
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.92A 4r7iA-5tvtA:
21.9
4r7iA-5tvtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ALA A  38
LYS A  40
LEU A  61
CYH A  89
GLY A  92
HIS A 130
LEU A 139
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
7LV  A 401 (-4.3A)
None
None
7LV  A 401 (-4.9A)
0.74A 4u0iA-5tvtA:
22.2
4u0iA-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ALA A  38
LYS A  40
LEU A  61
CYH A  89
GLY A  92
LEU A 139
ASP A 150
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.86A 4u0iA-5tvtA:
22.2
4u0iA-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 11 GLY A  20
VAL A  25
ALA A  38
TYR A  88
GLY A  92
ASN A 137
LEU A 139
ASP A 150
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
None
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.73A 4u5jA-5tvtA:
19.4
4u5jA-5tvtA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 12 VAL A  25
ALA A  38
LYS A  40
CYH A  89
ASP A 150
PHE A 151
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
None
0.91A 4xv2A-5tvtA:
23.0
4xv2A-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 ALA A  38
LYS A  40
CYH A  89
ASP A 150
PHE A 151
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
None
0.80A 4xv2B-5tvtA:
23.6
4xv2B-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 VAL A  25
ALA A  38
LYS A  40
CYH A  89
PHE A 151
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
None
0.83A 5cswA-5tvtA:
23.1
5cswA-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 12 VAL A  25
ALA A  38
LYS A  40
CYH A  89
PHE A 151
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
None
0.82A 5cswB-5tvtA:
22.9
5cswB-5tvtA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
6 / 12 ALA A  38
LYS A  40
GLU A  57
LEU A  61
CYH A  89
HIS A 130
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.3A)
None
0.73A 5hi2A-5tvtA:
23.6
5hi2A-5tvtA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 11 GLY A  18
VAL A  25
ALA A  38
LEU A  86
TYR A  88
GLU A  93
LEU A 139
7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 ( 4.2A)
7LV  A 401 (-4.6A)
7LV  A 401 ( 4.7A)
7LV  A 401 (-4.9A)
0.30A 5lvnA-5tvtA:
30.4
5lvnA-5tvtA:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 5 LEU A  61
CYH A  70
CYH A  89
ASP A 150
None
7LV  A 401 ( 3.7A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
0.72A 5mafA-5tvtA:
45.6
5mafA-5tvtA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 5 LEU A  61
CYH A  70
CYH A  89
LEU A 139
None
7LV  A 401 ( 3.7A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
0.19A 5mafA-5tvtA:
45.6
5mafA-5tvtA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
5 / 8 ALA A  38
GLU A  57
CYH A  89
LEU A 139
ASP A 150
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.63A 5owrA-5tvtA:
22.3
5owrA-5tvtA:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 12 GLU A  15
ILE A  17
GLY A  18
ALA A  38
GLU A  57
TYR A  88
CYH A  89
ASP A 150
None
7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.2A)
0.92A 5vc3A-5tvtA:
25.9
5vc3A-5tvtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ILE A  17
GLY A  18
GLU A  57
TYR A  88
CYH A  89
GLY A  92
ASP A 150
7LV  A 401 (-4.3A)
7LV  A 401 ( 3.9A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.2A)
0.88A 5vc3A-5tvtA:
25.9
5vc3A-5tvtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
7 / 12 ALA A  38
LYS A  40
GLU A  57
CYH A  89
GLY A  92
LEU A 139
ASP A 150
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.85A 5y7zB-5tvtA:
25.4
5y7zB-5tvtA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  57
CYH A  89
GLY A  92
LEU A 139
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.75A 5y80A-5tvtA:
25.0
5y80A-5tvtA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 8 VAL A  25
LYS A  40
ILE A 149
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
0.59A 5y9mX-5tvtA:
22.8
5y9mX-5tvtA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
4 / 7 VAL A  25
LYS A  40
ILE A 149
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
0.72A 5yf9B-5tvtA:
22.7
5yf9B-5tvtA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
3 / 3 LYS A  40
LEU A 139
ASP A 150
7LV  A 401 (-3.0A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.86A 5zv2A-5tvtA:
22.3
5zv2A-5tvtA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo
sapiens)
8 / 12 VAL A  25
ALA A  38
LYS A  40
GLU A  57
TYR A  88
GLY A  92
LEU A 139
ASP A 150
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
1.39A 6bsdA-5tvtA:
21.9
6bsdA-5tvtA:
15.54