SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7LK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASN A 172
LEU A 174
ASP A 186
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.8A)
None
 0.73A 1fmoE-5turA:
29.2		 1fmoE-5turA:
23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		10 / 10 LEU A  44
PHE A  49
ALA A  65
ILE A 104
LEU A 120
ARG A 122
PRO A 123
ASP A 128
LEU A 174
ILE A 185
 None
7LK  A 401 ( 4.4A)
7LK  A 401 (-3.3A)
7LK  A 401 (-4.8A)
7LK  A 401 (-4.0A)
None
None
7LK  A 401 ( 3.9A)
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
 0.62A 1yi4A-5turA:
44.3		 1yi4A-5turA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
LYS A  67
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 3.9A)
None
7LK  A 401 (-4.8A)
None
 0.58A 2eufB-5turA:
26.5		 2eufB-5turA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		8 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 186
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
None
 0.74A 2ityA-5turA:
23.1		 2ityA-5turA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
 None
None
7LK  A 401 (-4.9A)
None
None
None
None
 0.57A 2ivuA-5turA:
25.3		 2ivuA-5turA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 6 LEU A  44
VAL A  52
LYS A  67
LEU A 174
 None
7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
 0.57A 3cs9D-5turA:
20.4		 3cs9D-5turA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 0.65A 3gp0A-5turA:
21.5		 3gp0A-5turA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
GLU A  89
LEU A  92
LEU A  93
 7LK  A 401 (-3.3A)
None
None
None
None
 0.74A 3hecA-5turA:
21.0		 3hecA-5turA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
ILE A 104
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 1.03A 3hegA-5turA:
20.8		 3hegA-5turA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 ALA A  65
LYS A  67
GLU A  89
LEU A 118
 7LK  A 401 (-3.3A)
None
None
None
 0.28A 3lfaA-5turA:
20.7		 3lfaA-5turA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
7LK  A 401 (-4.8A)
 0.69A 3ohtA-5turA:
5.2		 3ohtA-5turA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.88A 3ug2A-5turA:
23.2		 3ug2A-5turA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 LYS A  67
ILE A 104
ILE A 185
ASP A 186
 None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.52A 3warA-5turA:
25.2		 3warA-5turA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 4.3A)
None
 0.51A 3warA-5turA:
25.2		 3warA-5turA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A  93
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 0.52A 4agcA-5turA:
21.1		 4agcA-5turA:
26.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		12 / 12 PHE A  49
VAL A  52
ALA A  65
ILE A 104
ASP A 128
ASP A 131
ASP A 167
LYS A 169
ASN A 172
LEU A 174
ILE A 185
ASP A 186
 7LK  A 401 ( 4.4A)
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 (-4.8A)
7LK  A 401 ( 3.9A)
7LK  A 401 (-3.0A)
None
None
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.59A 4i41A-5turA:
44.2		 4i41A-5turA:
70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 4 LEU A  44
LEU A 120
GLN A 127
GLU A 171
 None
7LK  A 401 (-4.0A)
None
None
 0.56A 4i41A-5turA:
44.2		 4i41A-5turA:
70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		11 / 11 PHE A  49
VAL A  52
ALA A  65
LYS A  67
LEU A 120
VAL A 126
ASP A 128
GLU A 171
LEU A 174
ILE A 185
ASP A 186
 7LK  A 401 ( 4.4A)
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.0A)
None
7LK  A 401 ( 3.9A)
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.51A 4iaaA-5turA:
44.2		 4iaaA-5turA:
71.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 106
LEU A 118
LEU A 174
ILE A 185
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
 0.60A 4ifgA-5turA:
23.0		 4ifgA-5turA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 8 VAL A  52
ALA A  65
ASP A 128
ASN A 172
ASP A 186
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 ( 3.9A)
None
None
 0.63A 4ogrA-5turA:
27.0		 4ogrA-5turA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 9 VAL A  52
ALA A  65
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 ( 3.9A)
None
7LK  A 401 (-4.8A)
None
 0.75A 4ogrI-5turA:
27.0		 4ogrI-5turA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 9 LEU A  44
VAL A  52
LYS A  67
ILE A 104
ARG A 166
LEU A 174
 None
7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
None
7LK  A 401 (-4.8A)
 0.78A 4v01B-5turA:
21.5		 4v01B-5turA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.68A 4wkqA-5turA:
23.9		 4wkqA-5turA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
ASP A 186
PHE A 187
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.69A 4xv2A-5turA:
22.8		 4xv2A-5turA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 ALA A  65
LYS A  67
LEU A  93
ASP A 186
PHE A 187
 7LK  A 401 (-3.3A)
None
None
None
None
 0.82A 4xv2B-5turA:
22.9		 4xv2B-5turA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 9 LEU A  44
VAL A  52
ALA A  65
LEU A 120
LEU A 174
ASP A 186
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
7LK  A 401 (-4.0A)
7LK  A 401 (-4.8A)
None
 0.85A 5aaaA-5turA:
21.8		 5aaaA-5turA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 10 LEU A  44
VAL A  52
ALA A  65
LYS A  67
LEU A 120
LEU A 174
ASP A 186
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.0A)
7LK  A 401 (-4.8A)
None
 0.97A 5aabA-5turA:
21.7		 5aabA-5turA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.73A 5cswA-5turA:
22.7		 5cswA-5turA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 VAL A  52
ALA A  65
LYS A  67
LEU A  93
PHE A 187
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.78A 5cswB-5turA:
22.7		 5cswB-5turA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 GLY A  45
GLY A  47
VAL A  52
LYS A  67
 None
None
7LK  A 401 (-4.9A)
None
 0.46A 5izjA-5turA:
28.0		 5izjA-5turA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 GLY A  45
GLY A  47
VAL A  52
LYS A  67
ASP A 186
 None
None
7LK  A 401 (-4.9A)
None
None
 0.85A 5j5xA-5turA:
28.9		 5j5xA-5turA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 GLY A  45
VAL A  52
ALA A  65
VAL A 126
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.8A)
 1.02A 5lw1H-5turA:
21.9		 5lw1H-5turA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
VAL A  52
ALA A  65
LYS A  67
GLU A  89
LEU A 118
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
 0.64A 5vcyA-5turA:
24.6		 5vcyA-5turA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
VAL A 126
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
 0.86A 5xv7A-5turA:
23.8		 5xv7A-5turA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		7 / 12 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
LEU A 174
ASP A 186
 None
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
None
 0.78A 5y7zB-5turA:
25.8		 5y7zB-5turA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 8 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 4.3A)
None
 0.37A 5y9mX-5turA:
24.4		 5y9mX-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		4 / 7 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 4.3A)
None
 0.58A 5yf9B-5turA:
24.3		 5yf9B-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 9 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.63A 5yf9X-5turA:
24.9		 5yf9X-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
 0.56A 5yu9A-5turA:
21.7		 5yu9A-5turA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		6 / 12 GLY A  45
VAL A  52
ALA A  65
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.84A 5yu9B-5turA:
21.9		 5yu9B-5turA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens) 		5 / 7 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.47A 5ywmX-5turA:
24.9		 5ywmX-5turA:
11.63