SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7LF'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 PHE A  84
ALA A  20
PHE A  27
PHE A  17
 7LF  A 502 (-4.0A)
None
None
None
 1.16A 1lqtA-5tvjA:
undetectable		 1lqtA-5tvjA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 PHE A  84
ALA A  20
PHE A  27
PHE A  17
 7LF  A 502 (-4.0A)
None
None
None
 1.17A 1lquA-5tvjA:
undetectable		 1lquA-5tvjA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
TYR A 126
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
 0.93A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
VAL A  85
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
 0.62A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
VAL A  85
GLU A 203
GLU A 401
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
7LF  A 502 (-3.3A)
 0.75A 4jd6A-5tvjA:
61.2		 4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
TYR A 126
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
 0.90A 4jd6B-5tvjA:
61.2		 4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
VAL A  85
GLU A 203
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
 0.59A 4jd6B-5tvjA:
61.2		 4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
TYR A 126
GLU A 203
GLU A 401
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
7LF  A 502 (-3.3A)
 1.00A 4jd6B-5tvjA:
61.2		 4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
VAL A  85
GLU A 203
GLU A 401
 7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
7LF  A 502 (-3.3A)
 0.68A 4jd6B-5tvjA:
61.2		 4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 SER A  83
LEU A 118
SER A 121
TYR A 126
ASP A 292
 7LF  A 502 (-3.5A)
COA  A 501 ( 4.8A)
COA  A 501 ( 4.4A)
COA  A 501 (-4.0A)
None
 0.75A 4qb9E-5tvjA:
50.7		 4qb9E-5tvjA:
60.42