SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7L6'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 9 LEU A1086
ASP A1074
ALA A1077
VAL A1079
GLU A1070
7L6  A1506 (-4.2A)
None
7L6  A1506 (-3.6A)
None
None
1.45A 4zbrA-5tuyA:
undetectable
4zbrA-5tuyA:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
1.09A 5jhnA-5tuyA:
26.4
5jhnA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.41A 5jhnA-5tuyA:
26.4
5jhnA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
1.03A 5jhnB-5tuyA:
41.3
5jhnB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.38A 5jhnB-5tuyA:
41.3
5jhnB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.44A 5jinA-5tuyA:
26.3
5jinA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.46A 5jinB-5tuyA:
41.2
5jinB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.42A 5jiyA-5tuyA:
41.8
5jiyA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.44A 5jiyB-5tuyA:
41.1
5jiyB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.44A 5jj0A-5tuyA:
26.5
5jj0A-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.44A 5jj0B-5tuyA:
41.1
5jj0B-5tuyA:
97.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 12 GLY A1049
ASN A1112
HIS A1113
TYR A1154
PHE A1158
SAM  A1505 ( 3.9A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
0.61A 5kklB-5tuyA:
4.1
5kklB-5tuyA:
14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
1.06A 5t0kA-5tuyA:
41.4
5t0kA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.36A 5t0kA-5tuyA:
41.4
5t0kA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.44A 5t0kB-5tuyA:
38.5
5t0kB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.43A 5t0mA-5tuyA:
41.1
5t0mA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
1.10A 5t0mB-5tuyA:
41.5
5t0mB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.34A 5t0mB-5tuyA:
41.5
5t0mB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.21A 5ttfA-5tuyA:
42.0
5ttfA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.22A 5ttfB-5tuyA:
42.1
5ttfB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
10 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
ZN  A1504 (-2.2A)
None
0.71A 5ttfC-5tuyA:
41.7
5ttfC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.43A 5ttfC-5tuyA:
41.7
5ttfC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.36A 5ttfD-5tuyA:
41.2
5ttfD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
1.34A 5ttgA-5tuyA:
39.7
5ttgA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.33A 5ttgA-5tuyA:
39.7
5ttgA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
6 / 11 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
1.33A 5ttgB-5tuyA:
24.5
5ttgB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.36A 5ttgB-5tuyA:
24.5
5ttgB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.00A 5tuyA-5tuyA:
45.9
5tuyA-5tuyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.16A 5tuyB-5tuyA:
42.4
5tuyB-5tuyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
CYH A1170
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
0.37A 5tuzA-5tuyA:
25.2
5tuzA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.31A 5tuzB-5tuyA:
24.8
5tuzB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.25A 5v9iA-5tuyA:
41.3
5v9iA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.26A 5v9iB-5tuyA:
41.5
5v9iB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.35A 5v9iC-5tuyA:
41.0
5v9iC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.43A 5v9iD-5tuyA:
41.0
5v9iD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
1.38A 5v9jA-5tuyA:
39.9
5v9jA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.31A 5v9jA-5tuyA:
39.9
5v9jA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
1.34A 5v9jB-5tuyA:
40.2
5v9jB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.33A 5v9jB-5tuyA:
40.2
5v9jB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.21A 5vscA-5tuyA:
41.6
5vscA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.23A 5vscB-5tuyA:
26.1
5vscB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.34A 5vsdA-5tuyA:
24.9
5vsdA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
1.36A 5vsdB-5tuyA:
24.9
5vsdB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.34A 5vsdB-5tuyA:
24.9
5vsdB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.24A 5vseA-5tuyA:
41.9
5vseA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
0.22A 5vseB-5tuyA:
41.6
5vseB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.35A 5vsfA-5tuyA:
25.2
5vsfA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo
sapiens)
11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
0.28A 5vsfB-5tuyA:
40.0
5vsfB-5tuyA:
79.07