SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7E8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		5 / 12 GLY A 193
SER A 199
LEU A 229
MET A 226
LEU A  77
 None
None
7E8  A 404 ( 3.2A)
7E8  A 404 (-4.0A)
None
 1.14A 1fm6D-5bz3A:
undetectable		 1fm6D-5bz3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 4 ASP A  79
THR A  75
VAL A  83
SER A 142
 None
None
None
7E8  A 402 ( 3.8A)
 0.80A 3wxoA-5bz3A:
0.1		 3wxoA-5bz3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
(Thermus
thermophilus) 		5 / 12 ASP A  17
VAL A  14
ASP A  23
LEU A  29
PHE A  93
 None
None
None
7E8  A1300 (-4.7A)
None
 1.38A 4pevC-2yevA:
undetectable		 4pevC-2yevA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 GLU A  57
GLY A 277
GLY A  43
ALA A 274
 7E8  A 401 ( 4.1A)
None
None
None
 0.83A 5e26A-5bz3A:
undetectable
5e26B-5bz3A:
undetectable		 5e26A-5bz3A:
22.84
5e26B-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 ALA A 274
GLU A  57
GLY A 277
GLY A  43
 None
7E8  A 401 ( 4.1A)
None
None
 0.81A 5e26A-5bz3A:
undetectable
5e26B-5bz3A:
undetectable		 5e26A-5bz3A:
22.84
5e26B-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 7 GLU A  57
GLY A 277
GLY A  43
ALA A 274
 7E8  A 401 ( 4.1A)
None
None
None
 0.83A 5e26C-5bz3A:
undetectable
5e26D-5bz3A:
undetectable		 5e26C-5bz3A:
22.84
5e26D-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		4 / 8 ALA A 274
GLU A  57
GLY A 277
GLY A  43
 None
7E8  A 401 ( 4.1A)
None
None
 0.85A 5e26C-5bz3A:
undetectable
5e26D-5bz3A:
undetectable		 5e26C-5bz3A:
22.84
5e26D-5bz3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5bz3 NA(+)/H(+)
ANTIPORTER
(Thermus
thermophilus) 		3 / 3 ARG A 183
LEU A 187
PHE A 191
 7E8  A 404 ( 2.6A)
7E8  A 404 ( 4.2A)
None
 0.64A 6nknP-5bz3A:
undetectable		 6nknP-5bz3A:
23.08