SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '7C5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		3 / 3 ALA A 173
VAL A 163
TRP A  40
 None
7C5  A 302 (-4.6A)
None
 0.91A 1micA-5th5A:
undetectable
1micB-5th5A:
undetectable		 1micA-5th5A:
4.26
1micB-5th5A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		5 / 12 THR A 125
SER A 159
TYR A 186
PHE A  28
THR A  79
 None
None
None
7C5  A 302 (-4.2A)
None
 1.31A 1q23B-5th5A:
undetectable		 1q23B-5th5A:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		5 / 12 ASP A  42
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 ( 3.0A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.71A 4njgA-5th5A:
19.5		 4njgA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		6 / 12 GLU A  18
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.50A 4njgA-5th5A:
19.5		 4njgA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		6 / 12 ASP A  42
SER A 127
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.1A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.66A 4njgB-5th5A:
19.5		 4njgB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		6 / 12 GLU A  18
SER A 127
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.1A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.53A 4njgB-5th5A:
19.5		 4njgB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLU A  18
THR A  79
LYS A 161
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
None
7C5  A 302 (-3.5A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 1.24A 4njgB-5th5A:
19.5		 4njgB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.43A 4njhA-5th5A:
19.7		 4njhA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.42A 4njhB-5th5A:
19.5		 4njhB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.46A 4njiA-5th5A:
19.7		 4njiA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.43A 4njiB-5th5A:
19.7		 4njiB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.46A 4njjA-5th5A:
19.7		 4njjA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.43A 4njjB-5th5A:
19.7		 4njjB-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.41A 4njkA-5th5A:
19.6		 4njkA-5th5A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		7 / 12 GLU A  18
ASP A  42
GLU A 108
LYS A 161
VAL A 163
GLN A 188
GLN A 231
 7C5  A 302 (-3.2A)
7C5  A 302 ( 3.0A)
7C5  A 302 ( 3.7A)
7C5  A 302 (-3.5A)
7C5  A 302 (-4.6A)
7C5  A 302 (-4.0A)
7C5  A 302 (-3.2A)
 0.40A 4njkB-5th5A:
19.6		 4njkB-5th5A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		3 / 3 PRO A 230
LEU A 229
GLN A  16
 None
None
7C5  A 302 (-3.5A)
 0.60A 4pevB-5th5A:
undetectable		 4pevB-5th5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_B_PARB500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		5 / 9 PHE A 185
SER A 127
THR A 125
ASP A 123
GLY A  19
 None
7C5  A 302 ( 3.1A)
None
None
None
 1.43A 4qb9B-5th5A:
0.5		 4qb9B-5th5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE
(Bacillus
subtilis) 		4 / 4 PHE A 165
ASP A 169
GLY A 190
SER A 132
 None
None
7C5  A 302 ( 3.8A)
None
 1.44A 4xp9C-5th5A:
undetectable		 4xp9C-5th5A:
19.29